LIMS1 - LIM zinc finger domain containing 1 Gene

Homo sapiens

Also known as PINCH; PINCH1; PINCH-1

Gene ID: 3987 | Gene type: protein coding

About LIMS1

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:108,533,671-108,687,246 (from NCBI)

This gene has 23 transcripts (splice variants), 30 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 18.5), adrenal (RPKM 16.0) and 25 other tissues.

Summary

The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in Integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

LIMS1 Products(16)

mRNA	Protein	Name
NM_001193482.2	NP_001180411.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform c
NM_001193483.3	NP_001180412.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform d
NM_001193484.2	NP_001180413.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform e
NM_001193485.3	NP_001180414.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform a
NM_001193488.2	NP_001180417.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform b
NM_001371494.1	NP_001358423.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform f
NM_001371495.1	NP_001358424.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform g
NM_001371496.1	NP_001358425.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform h
NM_001371497.1	NP_001358426.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform i
NM_001371498.1	NP_001358427.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform b
NM_001371499.1	NP_001358428.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform j
NM_001371500.1	NP_001358429.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform k
NM_001394896.1	NP_001381825.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform l
NM_001394897.1	NP_001381826.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform m
NM_001394898.1	NP_001381827.1	LIM and senescent cell antigen-like-containing domain protein 1 isoform n
NM_004987.6	NP_004978.2	LIM and senescent cell antigen-like-containing domain protein 1 isoform b

LIMS1 Protein Structure

LIM

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

LIM and senescent cell antigen-like-containing domain protein 1

LIM and senescent cell antigen-like domains 1

Related Diseases

Diseases

Alias

Chromosome 3q13.31 Deletion Syndrome

3q13 Microdeletion Syndrome	Monosomy 3q13
Chromosome 3, Monosomy 3q13	Del(3)(Q13)

Heinz Body Anemias

Heinz Body Anemia	Heinz Body Anemias, Alpha-
HEIBAN	Anemia, Heinz Body
Acquired Heinz Body Anemia

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07668	LIMS1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LIMS1	VGNC	VGNC:81113
Macaca mulatta	LIMS1	VGNC	VGNC:74271
Rattus norvegicus	LIMS1	RGD	RGD:1560732
Bos taurus	LIMS1	VGNC	VGNC:50211
Mus musculus	LIMS1	MGD	MGI:1195263
Others	LIMS1	NCBI

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