Pinch-1 Antibody (YA5019)
(Synonyms: LIMS1; PINCH; PINCH1; LIM and senescent cell antigen-like-containing domain protein 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48)Pinch-1 Antibody (YA5019) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Pinch-1.
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Host:
Mouse
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Application:
WB, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
Pinch-1 Antibody (YA5019) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Pinch-1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 37 kDa;
Purified recombinant fragment of human Pinch-1 expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Pinch-1 is a Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration
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Subcellular Localization
Cell junction, focal adhesion; Cell membrane; Peripheral membrane protein; Cytoplasmic side
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Expression
Tissue_specificity:It is expressed in most tissues except the brain. -
Isoforms & Post-Translational Modification
P48059 has 5 isomers: P48059-1: 37251 Da (predicted); P48059-2: 38422 Da (predicted); P48059-3: 44390 Da (predicted); P48059-4: 37701 Da (predicted); P48059-5: 41571 Da (predicted).
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Subunit
Component of the heterotrimeric IPP (ILK-PINCH-PARVIN) complex composed of ILK, LIMS1/PINCH and PARVA; the complex binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling (PubMed:11331308, PubMed:12432066, PubMed:30367047).
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SwissProt ID
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Synonyms
LIMS1; PINCH; PINCH1; LIM and senescent cell antigen-like-containing domain protein 1; Particularly interesting new Cys-His protein 1; PINCH-1; Renal carcinoma antigen NY-REN-48
Documentation
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