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ASB9 - ankyrin repeat and SOCS box containing 9 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 140462

About ASB9

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:15,243,987-15,270,467 (from NCBI)

This gene has 9 transcripts (splice variants), 129 orthologues and 2 paralogues. Biased expression in testis (RPKM 16.8), kidney (RPKM 5.8) and 8 other tissues.

Summary

This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin Ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

ASB9 Products (4)

mRNA	Protein	Name
NM_001031739.3	NP_001026909.1	ankyrin repeat and SOCS box protein 9 isoform 1
NM_001168530.2	NP_001162002.1	ankyrin repeat and SOCS box protein 9 isoform 3
NM_001168531.2	NP_001162003.1	ankyrin repeat and SOCS box protein 9 isoform 2
NM_024087.3	NP_076992.1	ankyrin repeat and SOCS box protein 9 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	25654263	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	17148442	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	25654263	GOA
acts upstream of or within protein ubiquitination	IDA IDA: Inferred from direct assay	17148442	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	23837592	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB9 Protein Structure

Ank_4

Ank_2

Ank

SOCS_box

0
100
200
294 a.a.

Protein Preferred Names	Protein Names
ankyrin repeat and SOCS box protein 9	ASB-9

ASB9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ASB9	Q96DX5	CKMT1A	Homo sapiens	P12532	Anti Tag CoIP	33961781
Intra	ASB9	Q96DX5	CKMT1A	Homo sapiens	P12532	Y2H Array	32296183
Intra	ASB9	Q96DX5	CKMT1A	Homo sapiens	P12532	Y2H Prey Pooling	32296183
Intra	ASB9	Q96DX5	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	ASB9	Q96DX5	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	ASB9	Q96DX5	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	ASB9	Q96DX5	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	ASB9	Q96DX5	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	ASB9	Q96DX5	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	ASB9	Q96DX5	ELOC	Homo sapiens	Q15369	Anti Tag CoIP	33961781
Intra	ASB9	Q96DX5	ELOC	Homo sapiens	Q15369	Anti Tag CoIP	28514442
Intra	ASB9	Q96DX5	CKB	Homo sapiens	P12277	Anti Tag CoIP	33961781
Intra	ASB9	Q96DX5	CKB	Homo sapiens	P12277	Anti Tag CoIP	28514442
Intra	ASB9	Q96DX5	CKB	Homo sapiens	P12277	Y2H Prey Pooling	32296183
Intra	ASB9	Q96DX5	CKB	Homo sapiens	P12277	Y2H Array	19060904
Intra	ASB9	Q96DX5	CKB	Homo sapiens	P12277	Y2H Array	25416956
Intra	ASB9	Q96DX5	CKB	Homo sapiens	P12277	Y2H Pooling	19060904
Intra	ASB9	Q96DX5	CKB	Homo sapiens	P12277	Y2H Array	32296183
Intra	ASB9	Q96DX5	EXOSC1	Homo sapiens	Q9Y3B2	Validated Y2H	32296183
Intra	ASB9	Q96DX5	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	ASB9	Q96DX5	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	ASB9	Q96DX5	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	ASB9	Q96DX5	CKM	Homo sapiens	P06732	Y2H Array	25416956
Intra	ASB9	Q96DX5	CKM	Homo sapiens	P06732	Anti Tag CoIP	33961781
Intra	ASB9	Q96DX5	CKM	Homo sapiens	P06732	Y2H Prey Pooling	32296183
Intra	ASB9	Q96DX5	CKM	Homo sapiens	P06732	Anti Tag CoIP	28514442
Intra	ASB9	Q96DX5	CKM	Homo sapiens	P06732	Y2H	21516116
Intra	ASB9	Q96DX5	CKM	Homo sapiens	P06732	Validated Y2H	25416956
Intra	ASB9	Q96DX5	CKM	Homo sapiens	P06732	Y2H Array	32296183
Intra	ASB9	Q96DX5	HIF1AN	Homo sapiens	Q9NWT6	Y2H Array	31515488
Intra	ASB9	Q96DX5	HIF1AN	Homo sapiens	Q9NWT6	Y2H Pooling	19060904
Intra	ASB9	Q96DX5	HIF1AN	Homo sapiens	Q9NWT6	Anti Tag CoIP	33961781
Intra	ASB9	Q96DX5	HIF1AN	Homo sapiens	Q9NWT6	Anti Tag CoIP	28514442
Intra	ASB9	Q96DX5	HIF1AN	Homo sapiens	Q9NWT6	Y2H Array	19060904
Intra	ASB9	Q96DX5	CRK	Homo sapiens	P46108	Lumier	25814554
Intra	ASB9	Q96DX5	CRK	Homo sapiens	P46108	Y2H Array	25814554

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fanconi Anemia, Complementation Group B	Fanconi Anemia Complementation Group B FANCB Facb Fa2 Fanconi Pancytopenia Type 2 Fanconi Pancytopenia, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01074	ASB9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ASB9	VGNC	VGNC:38169
Bos taurus	ASB9	VGNC	VGNC:26202
Felis catus	ASB9	VGNC	VGNC:59965
Rattus norvegicus	ASB9	RGD	RGD:1560537
Mus musculus	ASB9	MGD	MGI:1916549
Others	ASB9	NCBI