CKM - creatine kinase, M-type Gene

Also Known as CKMM; M-CK; CPK-M

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1158

About CKM

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,306,413-45,322,875 (from NCBI)

This gene has 1 transcript (splice variant), 282 orthologues and 4 paralogues. Biased expression in heart (RPKM 751.9), esophagus (RPKM 219.5) and 1 other tissue.

Summary

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in Other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

CKM Products (1)

mRNA	Protein	Name
NM_001824.5	NP_001815.2	creatine kinase M-type

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12972258	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CKM Protein Structure

ATP-gua_PtransN

ATP-gua_Ptrans

0
100
200
300
381 a.a.

Protein Preferred Names	Protein Names
creatine kinase M-type	creatine kinase M chain

CKM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CKM	P06732	CKMT1A	Homo sapiens	P12532	Validated Y2H	32296183
Intra	CKM	P06732	CKMT1A	Homo sapiens	P12532	Y2H Prey Pooling	32296183
Intra	CKM	P06732	CKMT1A	Homo sapiens	P12532	Y2H Array	32296183
Intra	CKM	P06732	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	CKM	P06732	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	CKM	P06732	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	CKM	P06732	ASB9	Homo sapiens	Q96DX5	Y2H Prey Pooling	25416956
Intra	CKM	P06732	ASB9	Homo sapiens	Q96DX5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CKM Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7827	Creatine kinase M-type/CKM Protein, Human (HEK293, His)	AAP35439.1 (M1-K381)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75340	Creatine kinase M-type/CKM Protein, Human (His)	AAH07462.1 (M1-K381)	≥ 95%, as determined by reducing SDS-PAGE.

CKM Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81316	Creatine Kinase MM Antibody (YA1061)	ELISA	Human
HY-P81316A	Creatine Kinase MM Antibody (YA1061)(PBS only)	ELISA	Human
HY-P85625	Creatine Kinase MM Antibody (YA5317)	ELISA	Human

Related Diseases

Diseases	Alias
Kidney Leiomyosarcoma	Leiomyosarcoma Of Kidney
Hemophilia B	Christmas Disease Factor Ix Deficiency F9 Deficiency HEMB Plasma Thromboplastin Component Deficiency Congenital Factor Ix Deficiency Mild Hemophilia B Severe Hemophilia B Congenital Factor Ix Disorder Deficiency, Functional Factor Ix Hem B Mild Congenital F9 Deficiency Mild Congenital Factor Ix Deficiency Moderate Hemophilia B Moderate Congenital F9 Deficiency Moderate Congenital Factor Ix Deficiency Severe Congenital F9 Deficiency Severe Congenital Factor Ix Deficiency Bleeding Disorder In Hemophilia B Carriers Congenital F9 Deficiency Recessive X-Linked Hemophilia B
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Myotonic Dystrophy 1	Myotonic Dystrophy Dystrophia Myotonica Steinert Disease Myotonic Dystrophy Type 1 Myotonia Atrophica DM1 Congenital Myotonic Dystrophy Myotonia Dystrophica Steinert Myotonic Dystrophy Dystrophia Myotonica 1 Dm Steinert'S Disease Steinert Myotonic Dystrophy Syndrome Myotonic Dystrophy Of Steinert Dystrophia Myotonica Type 1 Myotonic Dystrophy Congenital Dystrophy, Myotonic, Type 1 Dm - [Dystrophia Myotonica] Myotonic Muscular Dystrophy
Mcleod Syndrome	Mcleod Neuroacanthocytosis Syndrome MLS X-Linked Mcleod Syndrome Mcleod Phenotype Neuroacanthocytosis, Mcleod Type Mcleod Syndrome With Or Without Chronic Granulomatous Disease MCLDS Mcleod Type Neuroacanthocytosis Mcleod Syndrome With Chronic Granulomatous Disease Neuroacanthocytosis Mcleod Type Blood Group Deletion Syndrome
Acute Myocardial Infarction	Cardiac Attack Heart Attack
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Barbiturate Dependence
Epidermolysis Bullosa Simplex 5b, With Muscular Dystrophy	Epidermolysis Bullosa Simplex With Muscular Dystrophy Md-Ebs Epidermolysis Bullosa Simplex And Limb-Girdle Muscular Dystrophy EBS5B Ebsmd Mdebs Limb-Girdle Muscular Dystrophy With Epidermolysis Bullosa Simplex Ebs-Md Epidermolysa Bullosa Simplex And Limb Girdle Muscular Dystrophy Epidermolysa Bullosa Simplex With Muscular Dystrophy Epidermolysis Bullosa Simplex - Limb Girdle Muscular Dystrophy Ebs With Muscular Dystrophy Muscular Dystrophy With Epidermolysis Bullosa Simplex Epidermolysa Bullosa Simplex, With Muscular Dystrophy
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency
Prostate Rhabdomyosarcoma	Rhabdomyosarcoma Of The Prostate
Muscular Dystrophy, Duchenne Type	Duchenne Muscular Dystrophy DMD Muscular Dystrophy, Duchenne Muscular Dystrophy, Pseudohypertrophic Progressive, Duchenne Type Severe Dystrophinopathy, Duchenne Type Muscular Dystrophy Duchenne Dystrophy, Muscular, Duchenne Type Benign Duchenne Muscular Dystrophy Duchenne Motor Neuron Disease Duchenne Type Dystrophy Duchenne-Griesinger Disease
Myopathy	Muscular Diseases Myopathies
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02738	CKM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19104	Ckm Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25594	Ckm Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CKM	VGNC	VGNC:27385
Macaca mulatta	CKM	VGNC	VGNC:71230
Felis catus	CKM	VGNC	VGNC:60914
Mus musculus	CKM	MGD	MGI:88413
Rattus norvegicus	CKM	RGD	RGD:2358
Canis familiaris	CKM	VGNC	VGNC:39291
Others	CKM	NCBI