CRK - CRK proto-oncogene, adaptor protein Gene

Homo sapiens

Also known as p38; CRKII

Gene ID: 1398 | Gene type: protein coding

About CRK

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,420,693-1,456,232 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 27.5), thyroid (RPKM 27.2) and 25 other tissues.

Summary

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]

CRK Products(2)

mRNA	Protein	Name
NM_005206.5	NP_005197.3	adapter molecule crk isoform b
NM_016823.4	NP_058431.2	adapter molecule crk isoform a

CRK Protein Structure

SH2

SH3_1

SH3_2

0
100
200
304 a.a.

Protein Preferred Names

Protein Names

adapter molecule crk

proto-oncogene c-Crk

Related Diseases

Diseases

Alias

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome	17p13.3 Duplication Syndrome
17p13.3 Microduplication Syndrome	Trisomy 17p13.3
Chromosome 17p13.3 Centromeric Duplication Syndrome	Dup(17)(P13.3)

Miller-Dieker Lissencephaly Syndrome

Miller-Dieker Syndrome	Mds
MDLS	Miller Dieker Syndrome
Classical Lissencephaly Syndrome	Lissencephaly Due To 17p13.3 Deletion
Monosomy 17p13.3	Telomeric Deletion 17p
Classical Lissencephaly

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112622	GSK3186899	Inhibitor	98.61%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112346	RGB-286147		≥98.0%	Unkown
HY-RS16222	Crk Mouse Pre-designed siRNA Set A		/	Unkown
HY-143322	CRK12-IN-2	Inhibitor	/	Unkown
HY-145812	CRK12-IN-1	Inhibitor	/	Unkown
HY-RS03184	CRK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CRK	VGNC	VGNC:54290
Felis catus	CRK	VGNC	VGNC:98896
Bos taurus	CRK	VGNC	VGNC:27716
Rattus norvegicus	CRK	RGD	RGD:2405
Macaca mulatta	CRK	VGNC	VGNC:99140
Mus musculus	CRK	MGD	MGI:88508
Others	CRK	NCBI

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