MAP4K5 - mitogen-activated protein kinase kinase kinase kinase 5 Gene

Also Known as KHS; GCKR; KHS1; MAPKKKK5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11183

About MAP4K5

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:50,418,521-50,561,126 (from NCBI)

This gene has 10 transcripts (splice variants), 200 orthologues and 35 paralogues. Ubiquitous expression in endometrium (RPKM 13.1), ovary (RPKM 10.3) and 25 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

MAP4K5 Products (14)

mRNA Protein Name
XM_047430898.1 XP_047286854.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X5
XM_047430896.1 XP_047286852.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X4
XM_006720013.5 XP_006720076.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X3
XM_011536380.4 XP_011534682.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X6
XM_047430897.1 XP_047286853.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X4
XM_047430893.1 XP_047286849.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X1
NM_198794.4 NP_942089.1 mitogen-activated protein kinase kinase kinase kinase 5
XM_047430892.1 XP_047286848.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X1
XM_047430895.1 XP_047286851.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X4
XM_011536377.4 XP_011534679.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X4
NM_006575.6 NP_006566.2 mitogen-activated protein kinase kinase kinase kinase 5
XM_047430890.1 XP_047286846.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X1
XM_047430891.1 XP_047286847.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X1
XM_047430894.1 XP_047286850.1 mitogen-activated protein kinase kinase kinase kinase 5 isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9038372 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9788432 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9038372 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9038372 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9038372 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAP4K5 Protein Structure

Pkinase

Pkinase: Protein kinase domain (20 - 277)

CNH

CNH: CNH domain (516 - 816)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 846 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 5

  • MAPK/ERK kinase kinase kinase 5

  • MEK kinase kinase 5

  • MEKKK 5

  • germinal center kinase-related

  • kinase homologous to SPS1/STE20

MAP4K5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAP4K5 Q9Y4K4 NCK1 Homo sapiens P16333
Peptide Array
17474147
Intra
MAP4K5 Q9Y4K4 GRB2 Homo sapiens P62993
Pull Down
9788432
Intra
MAP4K5 Q9Y4K4 GRB2 Homo sapiens P62993
Peptide Array
17474147
Intra
MAP4K5 Q9Y4K4 GRB2 Homo sapiens P62993
Y2H Pooling
20936779
Intra
MAP4K5 Q9Y4K4 GRB2 Homo sapiens P62993
Pull Down
32707033
Intra
MAP4K5 Q9Y4K4 CRK Homo sapiens P46108
CoIP
9788432
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147141 HS-276 Inhibitor 98.93% Unkown
HY-N3127 Orobol Inhibitor 99.74% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-147141A HS-276 hydrochloride Inhibitor / Unkown
HY-147141B HS-276 formic Inhibitor / Unkown
HY-179111 HPK1-IN-64 Inhibitor / Unkown
HY-E70839 KHS1 Recombinant Human Active Protein Kinase / Unkown
HY-RS08083 MAP4K5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08084 Map4k5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08085 Map4k5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MAP4K5 MGD MGI:1925503
Bos taurus MAP4K5 VGNC VGNC:31208
Macaca mulatta MAP4K5 VGNC VGNC:81468
Felis catus MAP4K5 VGNC VGNC:80919
Canis familiaris MAP4K5 VGNC VGNC:42985
Rattus norvegicus MAP4K5 RGD RGD:1562028
Others MAP4K5 NCBI