HS-276 formic
Based on 2 publication(s) in Google Scholar
HS-276 formic is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 formic shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 formic reduces the expression of TNF, IL-6, and IL-1β. HS-276 formic can be used for rheumatoid arthritis (RA) research.
For research use only. We do not sell to patients.
- Formula: C25H31N5O4
- Molecular Weight:465.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) HS-276 formic
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Biological Activity
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IRAK1 264 nM (IC50) |
IRAK4 2500 nM (IC50) |
IL-6 201 nM (IC50) |
IL-1β 234 nM (IC50) |
HS-276 (CD-1 mice, 30 mg/kg, p.o., once) formic shows excellent bioavailability in mice with a Cmax of 3.68 μM and %F of 98.1%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 465.54
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Formula C25H31N5O4
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SMILES
O=C(C1=CC=CC(C(NC2=NC3=C(N2CCC)C=C(CN4CCCCC4)C=C3)=O)=C1)N.OC=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
Targeting tumor intrinsic TAK1 engages TNF-α-driven cell death through distinct mechanisms and enhances cancer immunotherapy. [Abstract]2025 Oct 16;16(1):725. PMID: 41102176 -
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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