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Referencia número: HY-147141B

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HS-276 formic

Name: HS-276 formic
Brand: MedChemExpress
SKU: HY-147141B
Availability: PreOrder

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

HS-276 formic is an orally active, potent and highly selective TAK1 inhibitor, with a K_i of 2.5 nM. HS-276 formic shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC₅₀ values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 formic reduces the expression of TNF, IL-6, and IL-1β. HS-276 formic can be used for rheumatoid arthritis (RA) research.

Para uso exclusivo en investigación. No vendemos a pacientes.

Fòrmula: C₂₅H₃₁N₅O₄
Peso molecular:465.54

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

HS-276 formic Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Pureza y Documentación
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Actividad biológica

Descripciòn

IC₅₀ & Target

^[1]

IRAK1

264 nM (IC₅₀)

IRAK4

2500 nM (IC₅₀)

IL-6

201 nM (IC₅₀)

IL-1β

234 nM (IC₅₀)

Ver todos los productos específicos de isoformas IRAK :

Ver todos los productos específicos de isoformas TNF Receptor :

Ver todos los productos específicos de isoformas Casein Kinase :

Ver todos los productos específicos de isoformas Interleukin Related :

In Vitro

HS-276 formic reduces expression of TNF, IL-6, and IL-1β in a dose-dependent manner, with IC₅₀ values of 138, 201, and 234 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HS-276 (CIA mouse model of inflammatory arthritis, 50 mg/kg, IP, daily for 6 days) formic reduces inflammation, pannus, cartilage damage (CD), bone resorption (BR), and periosteal bone formation (PBF) histological manifestations^[1].
HS-276 (CD-1 mice, 30 mg/kg, p.o., once) formic shows excellent bioavailability in mice with a C_max of 3.68 μM and %F of 98.1%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Peso molecular 465.54
Fòrmula C₂₅H₃₁N₅O₄
SMILES

O=C(C1=CC=CC(C(NC2=NC3=C(N2CCC)C=C(CN4CCCCC4)C=C3)=O)=C1)N.OC=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Cell Death Dis

Targeting tumor intrinsic TAK1 engages TNF-α-driven cell death through distinct mechanisms and enhances cancer immunotherapy. [Abstract]

2025 Oct 16;16(1):725. PMID: 41102176
bioRxiv

2026 Jan 25.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Scarneo S, et al. Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis. ACS Chem Biol. 2022 Mar 18;17(3):536-544. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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HS-276 formic

2 Cited Publications

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Pureza y Documentación
Referencias

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HS-276 formic

Publications Citing Use of MedChemExpress (MCE) HS-276 formic

Ver todos los productos específicos de isoformas IRAK

Ver todos los productos específicos de isoformas TNF Receptor

Ver todos los productos específicos de isoformas Casein Kinase

Ver todos los productos específicos de isoformas Interleukin Related