IRAK1
IRAK1 (interleukin-1 receptor-associated kinase 1) transduces signals from the Toll-like receptor and IL-1 receptor families. Upon IL-1 binding or TLR engagement, IRAK1 is recruited to the adaptor MyD88 through death-domain interactions, phosphorylated by IRAK4 within the Myddosome, and then associates with TRAF6 to activate NF-κB and MAPK pathways. Unlike IRAK2 and IRAK3, IRAK1 is catalytically active and, after hyperphosphorylation, dissociates from the receptor complex and is degraded by the ubiquitin-proteasome system, a step that limits and shapes signaling duration. Hyperactive IRAK1 variants have been reported in autoimmune and oncogenic settings. Recombinant IRAK1 supports kinase assays, Myddosome reconstitution and inhibitor screening.
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IRAK1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
