IRAK Inhibitors

IRAK1

IRAK3

IRAK4

IRAK Inhibitors, Modulators, Degraders & Ligands

Product Name	IRAK1	IRAK3	IRAK4	Purity
Zimlovisertib			IRAK4, IC₅₀: .2 nM	99.94%
KT-474			IRAK4	99.77%
Ginsenoside Rb1	IRAK-1			99.75%
AS2444697			IRAK4, IC₅₀: 21 nM	99.54%
Emavusertib			IRAK4, IC₅₀: 57 nM	99.97%
APH02174 hemiformic			IRAK4
Zabedosertib			IRAK4, IC₅₀: 3.55 nM	98.22%
JH-X-119-01	IRAK-1, IC₅₀: 9 nM			99.65%
HS-276	IRAK1, IC₅₀: 264 nM		IRAK4, IC₅₀: 2500 nM	98.93%
KME-2780	IRAK1, IC₅₀: 19 nM		IRAK4, IC₅₀: 0.5 nM	98.94%
JNJ-1013	IRAK1, IC₅₀: 72 nM		IRAK4, IC₅₀: 443 nM	99.97%
AZ1495	IRAK1, IC₅₀: 23 nM		IRAK4, IC₅₀: 5 nM	98.07%
IRAK4-IN-4			IRAK4, IC₅₀: 2.8 nM	99.55%
JH-X-119-01 hydrochloride	IRAK1			99.14%
Trimebutine	IRAK-1			99.42%
Trimebutine maleate	IRAK-1			99.66%
PROTAC IRAK4 degrader-1			IRAK4	99.77%
KTX-951			IRAK4, Kd: 3.5 nM IRAK4, DC₅₀: 18 nM	99.60%
IRAK1/4/pan-FLT3 Kinase-IN-1	IRAK-1, IC₅₀: 5 nM		IRAK4, IC₅₀: 0.6 nM	99.25%
IRAK4-IN-7			IRAK4	99.36%
BIO-7488			hIRAK4, IC₅₀: 0.5 nM	99.44%
PROTAC IRAK4 degrader-3			IRAK4	98.24%
Larotinib	IRAK1, IC₅₀: 167 nM			99.50%
HS-243	IRAK-1, IC₅₀: 24 nM		IRAK4, IC₅₀: 20 nM	99.95%
PROTAC IRAK4 degrader-13			IRAK4	99.47%
IRAK4-IN-20			IRAK4, IC₅₀: 3.55 nM
PSP-0119			IRAK4, IC₅₀: 2.83 nM	98.65%
GLPG2534	IRAK1, IC₅₀: 179 nM		hIRAK4, IC₅₀: 6.4 nM mIRAK4, IC₅₀: 3.5 nM	98.73%
FIP22			IRAK4, DC₅₀: 3.2 nM	98.53%
IRAK4-IN-14			IRAK4, IC₅₀: 0.003 μM	99.01%
IRAK inhibitor 2			IRAK4, IC₅₀: <20 μM	99.19%
Larotinib mesylate hydrate	IRAK-1, IC₅₀: 167 nM			98.66%
PF-06426779			IRAK4, IC₅₀: 0.3 nM	99.89%
IRAK-4 protein kinase inhibitor 2			IRAK4, IC₅₀: 4 μM	98.07%
APH02174			IRAK4, DC₅₀: 4.01 nM
HS271			IRAK4, IC₅₀: 7.2 μM	99.92%
UR241-2	IRAK1		IRAK4	99.68%
IRAK inhibitor 4			IRAK4	99.77%
Ginsenoside Rb1 (Standard)	IRAK-1
IRAK4 modulator-2	IRAK1, IC₅₀: 0.97 μM		IRAK4, IC₅₀: 0.005 μM μM	99.86%
GNE-2256			IRAK4, Ki: 1.4 nM	99.14%
IRAK inhibitor 4 (trans)			IRAK4	99.02%
Emavusertib hydrochloride			IRAK4, IC₅₀: 57 nM
IRAK4-IN-8			IRAK4
IRAK4-IN-18			IRAK4, IC₅₀: 15 nM
GLPG4471			IRAK4, IC₅₀: 1.7 nM
PROTAC IRAK4 degrader-5			IRAK4
Lomonitinib			IRAK4
IRAK4-IN-16			IRAK4, IC₅₀: 2.5 ± 0.8 nM
PROTAC IRAK4 ligand-4			IRAK4
HS-276 hydrochloride	IRAK1, IC₅₀: 264 nM		IRAK4, IC₅₀: 2500 nM
IRAK4-IN-9			IRAK4, IC₅₀: 1.5 nM
IRAK4-IN-10			IRAK4, IC₅₀: 1.5 nM
IRAK4-IN-13			IRAK4, IC₅₀: 0.6 nM
IRAK4-IN-31			IRAK4
JH-l-25-NH2			IRAK4
IRAK4 modulator-1			IRAK4, IC₅₀: 4.647 μM (^[1])	99.11%
PROTAC IRAK3 degrader-2		IRAK3, DC₅₀: ≤ 50 nM
DW18134			IRAK4, IC₅₀: 11.2 nM
PROTAC IRAK4 degrader-2			IRAK4
KTX-612			IRAK4, DC₅₀: 7 nM
AF-45	IRAK1, IC₅₀: 1765 nM		IRAK4, IC₅₀: 128 nM
BIO-8169			IRAK4, IC₅₀: 0.23 nM
GSI526			IRAK4
PROTAC IRAK4 degrader-4			IRAK4
BMS-986126			IRAK4, IC₅₀: 5.3 nM
KTX-497			IRAK4, DC₅₀: 3 nM
KTX-955			IRAK4, IC₅₀: 5 nM
IRAK4-IN-15			IRAK4, IC₅₀: 0.002 μM
IRAK4-IN-12			IRAK4, IC₅₀: 0.015 μM
IRAK4-IN-30			IRAK4, IC₅₀: 0.6 nM
IRAK4-IN-17			IRAK4, IC₅₀: 1.3 nM
PROTAC IRAK4 degrader-6			IRAK4
IRAK4-IN-11			IRAK4, IC₅₀: .008 μM
IRAK4-IN-19			IRAK4, IC₅₀: 4.3 nM
HG-12-6			IRAK4, IC₅₀: 165 nM (Unphosphorylated inactive IRAK4 ) IRAK4, IC₅₀: 2876 nM (Phosphorylated active IRAK4 )
HS-276 formic	IRAK1, IC₅₀: 264 nM		IRAK4, IC₅₀: 2500 nM
IRAK4 ligand-14			IRAK4
PROTAC IRAK4 degrader-14			IRAK4, DC₅₀: 2.4 nM
IRAK4-IN-24			IRAK4
IRAK4-IN-27			IRAK4, IC₅₀: 8.7 nM
Trimebutine-d₃ hydrochloride	IRAK-1
IRAK1-IN-2	IRAK1
Trimebutine-d₅ fumarate	IRAK-1
IRAK3 ligand-3		IRAK3
BMS-978299			IRAK4
Trimebutine maleate (Standard)	IRAK-1
IRAK4-IN-34			IRAK4, IC₅₀: 0.73 nM
Trimebutine (Standard)	IRAK-1
IRAK4-IN-32			IRAK4

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