HPK1-IN-64
HPK1-IN-64 is a potent, selective, and orally active HPK1 inhibitor with an IC50 value of 1.9 nM. HPK1-IN-64 exhibits selectivity exceeding 100-fold, 80-fold, 300-fold, and 350-fold against off-target kinases such as GLK, MAP4K5, TBK1, and TNIK, respectively. HPK1-IN-64 inhibits SLP76 protein phosphorylation and IL-2 secretion. HPK1-IN-64 may be used in cancer research, such as for colorectal cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3034320-17-4
- 分子式: C29H33N5O3
- 分子量:499.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MAP4K アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
HPK1 1.9 nM (IC50) |
IL-2 |
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:(CT26 tumor model)[1]
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Dosage:1.5 mg/kg, 5 mg/kg
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Administration:p.o.; twice daily
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Result:Inhibited tumor growth with TGI of 56% and 93%.
化学情報
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CAS 番号 3034320-17-4
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分子量 499.60
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分子式 C29H33N5O3
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SMILES
O=C1C(C2=C(C=C3C4=CN=C5N4CCC[C@H]5OC)C(C)(C6=CC(N7CCOCC7)=CC=C6N2)C)=C3CN1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HPK1-IN-64 関連分類
HY-179111 関連分類
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