HPK1-IN-64
HPK1-IN-64 is a potent, selective, and orally active HPK1 inhibitor with an IC50 value of 1.9 nM. HPK1-IN-64 exhibits selectivity exceeding 100-fold, 80-fold, 300-fold, and 350-fold against off-target kinases such as GLK, MAP4K5, TBK1, and TNIK, respectively. HPK1-IN-64 inhibits SLP76 protein phosphorylation and IL-2 secretion. HPK1-IN-64 may be used in cancer research, such as for colorectal cancer.
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- No. CAS: 3034320-17-4
- Fòrmula: C29H33N5O3
- Peso molecular:499.60
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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HPK1 1.9 nM (IC50) |
IL-2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:(CT26 tumor model)[1]
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Dosage:1.5 mg/kg, 5 mg/kg
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Administration:p.o.; twice daily
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Result:Inhibited tumor growth with TGI of 56% and 93%.
Chemical Information
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No. CAS 3034320-17-4
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Peso molecular 499.60
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Fòrmula C29H33N5O3
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SMILES
O=C1C(C2=C(C=C3C4=CN=C5N4CCC[C@H]5OC)C(C)(C6=CC(N7CCOCC7)=CC=C6N2)C)=C3CN1
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HPK1-IN-64 Related Classifications
HY-179111 Related Classifications
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