BUB1 - BUB1 mitotic checkpoint serine/threonine kinase Gene

Also Known as BUB1A; BUB1L; hBUB1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 699

About BUB1

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:110,637,528-110,678,063 (from NCBI)

This gene has 14 transcripts (splice variants), 218 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in testis (RPKM 25.2), lymph node (RPKM 11.3) and 10 other tissues.

Summary

This gene encodes a serine/threonine-protein kinase that play a central role in Mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of Cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

BUB1 Products (3)

mRNA	Protein	Name
NM_001278616.2	NP_001265545.1	mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 2
NM_001278617.2	NP_001265546.1	mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 3
NM_004336.5	NP_004327.1	mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone H2A kinase activity	IDA IDA: Inferred from direct assay	26658523	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10198256	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	18995837	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	22331848	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	25308863	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	18995837	GOA
involved in positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric	IMP IMP: Inferred from mutant phenotype	25308863	GOA
involved in regulation of chromosome segregation	IMP IMP: Inferred from mutant phenotype	19487456	GOA
involved in regulation of sister chromatid cohesion	IDA IDA: Inferred from direct assay	15723797	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in kinetochore	IDA IDA: Inferred from direct assay	15020684	GOA
part of outer kinetochore	IDA IDA: Inferred from direct assay	22331848	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BUB1 Protein Structure

Mad3_BUB1_I

Pkinase

0
200
400
600
800
1000
1085 a.a.

Protein Preferred Names	Protein Names
mitotic checkpoint serine/threonine-protein kinase BUB1	BUB1 budding uninhibited by benzimidazoles 1 homolog

BUB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BUB1	O43683	KNL1	Homo sapiens	Q8NG31	Anti Tag CoIP	33961781
Intra	BUB1	O43683	KNL1	Homo sapiens	Q8NG31	TAP	20360068
Intra	BUB1	O43683	KNL1	Homo sapiens	Q8NG31	Anti Bait CoIP	22660415
Intra	BUB1	O43683	BUB1B	Homo sapiens	O60566	Y2H Array	31515488
Intra	BUB1	O43683	BUB1B	Homo sapiens	O60566	Anti Tag CoIP	33961781
Intra	BUB1	O43683	BUB1B	Homo sapiens	O60566	TAP	20360068
Intra	BUB1	O43683	BUB3	Homo sapiens	O43684	Y2H Array	25416956
Intra	BUB1	O43683	BUB3	Homo sapiens	O43684	Y2H Array	21988832
Intra	BUB1	O43683	BUB3	Homo sapiens	O43684	Anti Tag CoIP	33961781
Intra	BUB1	O43683	KNL1	Homo sapiens	Q8NG31-2	Anti Tag CoIP	26496610
Intra	BUB1	O43683	KNL1	Homo sapiens	Q8NG31-2	Anti Tag CoIP	28514442
Intra	BUB1	O43683	KNL1	Homo sapiens	Q8NG31-2	Y2H	19141287
Intra	BUB1	O43683	ARIH2	Homo sapiens	O95376	Y2H Pooling	16189514
Intra	BUB1	O43683	ARIH2	Homo sapiens	O95376	Y2H Array	31515488
Intra	BUB1	O43683	ARIH2	Homo sapiens	O95376	Validated Y2H	32296183
Intra	BUB1	O43683	CRK	Homo sapiens	P46108	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

BUB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81822	BUB1 Antibody (YA1567)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Mosaic Variegated Aneuploidy Syndrome	Warburton-Anyane-Yeboa Syndrome Mva Syndrome Mosaic Variegated Aneuplody Microcephaly Syndrome Warburton Anyane Yeboa Syndrome
Polyploidy	Polyploid Polyploidy Syndrome
Prostate Carcinoma In Situ	Carcinoma In Situ Of Prostate Grade Iii Pin Pin Iii
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103020	BAY-1816032	Inhibitor	99.73%	Unkown
HY-104001	BAY-524	Inhibitor	98.36%	Unkown
HY-102081	2OH-BNPP1	Inhibitor	99.65%	Unkown
HY-104000	BAY-320	Inhibitor	99.74%	Unkown
HY-172089	TG101209 analog 1	Inducer	98.27%	Unkown
HY-161865	Antitumor agent-180	Inducer	99.46%	Unkown
HY-RS01681	BUB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01682	BUB1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-137343	DB-0646	Degrader	98.0%	Unkown
HY-148066	DB0662	Degrader	99.66%	Unkown
HY-RS17020	Bub1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19413	Bub1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23463	Bub1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25905	Bub1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BUB1	VGNC	VGNC:26604
Felis catus	BUB1	VGNC	VGNC:60210
Macaca mulatta	BUB1	VGNC	VGNC:70292
Mus musculus	BUB1	MGD	MGI:1100510
Canis familiaris	BUB1	VGNC	VGNC:38565
Rattus norvegicus	BUB1	RGD	RGD:1311707
Others	BUB1	NCBI