BUB3 - BUB3 mitotic checkpoint protein Gene

Also Known as BUB3L; hBUB3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9184

About BUB3

Cytogenetic location: 10q26.13 Genomic coordinates (GRCh38): 10:123,154,402-123,170,467 (from NCBI)

This gene has 5 transcripts (splice variants), 221 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 41.0), appendix (RPKM 28.0) and 25 other tissues.

Summary

This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

BUB3 Products (2)

mRNA	Protein	Name
NM_001007793.3	NP_001007794.1	mitotic checkpoint protein BUB3 isoform b
NM_004725.4	NP_004716.1	mitotic checkpoint protein BUB3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9660858	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in attachment of spindle microtubules to kinetochore	IDA IDA: Inferred from direct assay	18199686	GOA
involved in protein localization to kinetochore	IPI IPI: Inferred from physical interaction	9660858	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in kinetochore	IDA IDA: Inferred from direct assay	9660858	GOA
part of mitotic checkpoint complex	IPI IPI: Inferred from physical interaction	27509861	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BUB3 Protein Structure

WD40

0
100
200
300
328 a.a.

Protein Preferred Names	Protein Names
mitotic checkpoint protein BUB3	BUB3 budding uninhibited by benzimidazoles 3 homolog

BUB3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BUB3	O43684	BUB1B	Homo sapiens	O60566	MAPPIT	25416956
Intra	BUB3	O43684	BUB1B	Homo sapiens	O60566	Y2H Array	21988832
Intra	BUB3	O43684	BUB1B	Homo sapiens	O60566	Anti Tag CoIP	33961781
Intra	BUB3	O43684	BUB1B	Homo sapiens	O60566	Anti Tag CoIP	26496610
Intra	BUB3	O43684	PSTPIP1	Homo sapiens	O43586	Validated Y2H	25416956
Intra	BUB3	O43684	PSTPIP1	Homo sapiens	O43586	Y2H Array	25416956
Intra	BUB3	O43684	ZNF207	Homo sapiens	O43670	Y2H	21988832
Intra	BUB3	O43684	ZNF207	Homo sapiens	O43670	Anti Tag CoIP	33961781
Intra	BUB3	O43684	BUB1	Homo sapiens	O43683	Validated Y2H	25416956
Intra	BUB3	O43684	BUB1	Homo sapiens	O43683	Anti Tag CoIP	33961781
Intra	BUB3	O43684	BUB1	Homo sapiens	O43683	Anti Tag CoIP	26496610
Intra	BUB3	O43684	BUB1	Homo sapiens	O43683	Y2H Prey Pooling	25416956
Intra	BUB3	O43684	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	BUB3	O43684	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	BUB3	O43684	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Cross	BUB3	O43684	Dynlt3	Rattus norvegicus	Q5XI90	Pull Down	17289665

Cross: Cross-species interaction Intra: Intraspecies interaction

BUB3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82435	BUB3 Antibody (YA2180)	WB, IHC-P, ICC/IF, FC, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Mosaic Variegated Aneuploidy Syndrome	Warburton-Anyane-Yeboa Syndrome Mva Syndrome Mosaic Variegated Aneuplody Microcephaly Syndrome Warburton Anyane Yeboa Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01683	BUB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21302	Bub3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27821	Bub3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BUB3	RGD	RGD:1306654
Mus musculus	BUB3	MGD	MGI:1343463
Felis catus	BUB3	VGNC	VGNC:97370
Bos taurus	BUB3	VGNC	VGNC:26606
Macaca mulatta	BUB3	VGNC	VGNC:100304
Canis familiaris	BUB3	VGNC	VGNC:38567
Others	BUB3	NCBI