ZNF207 - zinc finger protein 207 Gene

Also Known as BuGZ; hBuGZ

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7756

About ZNF207

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:32,350,157-32,381,885 (from NCBI)

This gene has 17 transcripts (splice variants) and 251 orthologues. Ubiquitous expression in bone marrow (RPKM 30.2), lymph node (RPKM 22.5) and 25 other tissues.

Summary

Enables microtubule binding activity. Involved in several processes, including mitotic nuclear division; mitotic spindle assembly checkpoint signaling; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix. [provided by Alliance of Genome Resources, Apr 2022]

ZNF207 Products (3)

mRNA Protein Name
NM_001032293.3 NP_001027464.1 BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform b
NM_001098507.2 NP_001091977.1 BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform c
NM_003457.4 NP_003448.1 BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables microtubule binding IDA
IDA: Inferred from direct assay
24462186 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
Biological Process GO Annotation Evidence References Source
involved in attachment of spindle microtubules to kinetochore IMP
IMP: Inferred from mutant phenotype
24462186 GOA
involved in mitotic sister chromatid segregation IMP
IMP: Inferred from mutant phenotype
24462186 GOA
involved in mitotic spindle assembly IDA
IDA: Inferred from direct assay
26388440 GOA
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
24462186 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
24462186 GOA
involved in regulation of chromosome segregation IMP
IMP: Inferred from mutant phenotype
24462186 GOA
Cellular Component GO Annotation Evidence References Source
located in kinetochore IDA
IDA: Inferred from direct assay
24462187 GOA
located in kinetochore IMP
IMP: Inferred from mutant phenotype
24462186 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24462186 GOA
located in spindle matrix IDA
IDA: Inferred from direct assay
26388440 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

BUB3-interacting and GLEBS motif-containing protein ZNF207

ZNF207 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF207 O43670 BUB3 Homo sapiens O43684
Y2H
22365833
Intra
ZNF207 O43670 BUB3 Homo sapiens O43684
Confocal
21988832
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 15q26-Qter Deletion Syndrome

  • Drayer Syndrome

  • 15q26 Deletion Syndrome

  • Distal 15q Deletion Syndrome

  • Distal Monosomy 15q

  • Telomeric 15q Deletion Syndrome

  • Monosomy 15q26
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-161303 ZNF207-IN-1 98.03% Unkown
HY-182358 TMLZ-G46 Inducer / Unkown
HY-RS16109 ZNF207 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZNF207 RGD RGD:1308121
Felis catus ZNF207 VGNC VGNC:67275
Mus musculus ZNF207 MGD MGI:1340045
Macaca mulatta ZNF207 VGNC VGNC:78870
Bos taurus ZNF207 VGNC VGNC:37225
Others ZNF207 NCBI