ZNF207-IN-1

Cat. No.: HY-161303 Purity: 98.03%: Data Sheet
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ZNF207-IN-1 (compound C16) is a potent inhibitor of Zinc Finger Protein 207 (ZNF207)， with IC₅₀ values ranging from 0.5–2.5 μM for inhibiting sphere formation and 0.5–15 μM for cytotoxicity. ZNF207-IN-1 exhibites efficient permeability across the blood–brain barrier.

For research use only. We do not sell to patients.

ZNF207-IN-1 Chemical Structure

CAS No. : 2923208-52-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	9.68 μM Compound: C16	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38377560]
AGS	IC₅₀	9.42 μM Compound: C16	Antiproliferative activity against human AGS cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human AGS cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38377560]
H4	IC₅₀	0.72 μM Compound: C16	Antiproliferative activity against human H4 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay Antiproliferative activity against human H4 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay	[PMID: 38377560]
H4	IC₅₀	0.74 μM Compound: C16	Inhibition of sphere formation in human H4 cells incubated for 168 hrs by microscopic analysis Inhibition of sphere formation in human H4 cells incubated for 168 hrs by microscopic analysis	[PMID: 38377560]
HeLa	IC₅₀	8.13 μM Compound: C16	Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38377560]
Hs 683	IC₅₀	2.1 μM Compound: C16	Inhibition of sphere formation in human Hs 683 cells incubated for 168 hrs by microscopic analysis Inhibition of sphere formation in human Hs 683 cells incubated for 168 hrs by microscopic analysis	[PMID: 38377560]
Hs 683	IC₅₀	8.53 μM Compound: C16	Antiproliferative activity against human Hs 683 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay Antiproliferative activity against human Hs 683 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay	[PMID: 38377560]
LN-229	IC₅₀	1.23 μM Compound: C16	Inhibition of sphere formation in human LN-229 cells incubated for 168 hrs by microscopic analysis Inhibition of sphere formation in human LN-229 cells incubated for 168 hrs by microscopic analysis	[PMID: 38377560]
LN-229	IC₅₀	4.99 μM Compound: C16	Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay	[PMID: 38377560]
MKN-45	IC₅₀	3.84 μM Compound: C16	Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human MKN-45 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38377560]
NCI-H460	IC₅₀	15.64 μM Compound: C16	Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human NCI-H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38377560]
U-251	IC₅₀	0.87 μM Compound: C16	Inhibition of sphere formation in human U-251MG cells incubated for 168 hrs by microscopic analysis Inhibition of sphere formation in human U-251MG cells incubated for 168 hrs by microscopic analysis	[PMID: 38377560]
U-251	IC₅₀	13.09 μM Compound: C16	Antiproliferative activity against human U-251MG cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay Antiproliferative activity against human U-251MG cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay	[PMID: 38377560]
U-937	IC₅₀	13.97 μM Compound: C16	Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay Antiproliferative activity against human U-937 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay	[PMID: 38377560]

Molecular Weight

554.52

Formula

C₃₂H₃₂BrN₃O

CAS No.

2923208-52-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

N#CC1(CC2(C3=C(C1C4=C2C=CC=C4)C=CC=C3)Br)C(NCCC5CCN(CC5)CC6=CC=CC=C6)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 98.03%

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Data Sheet (272 KB) SDS (251 KB)

COA (255 KB) HNMR (272 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Menghan Zhang, et al. Discovery of Novel N-(Anthracen-9-ylmethyl) Benzamide Derivatives as ZNF207 Inhibitors Promising in Treating Glioma. J Med Chem. 2024 Feb 20. [Content Brief]

ZNF207-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZNF207-IN-12923208-52-8Zinc Finger Proteinstemness of glioma cellsblood–brain barrierInhibitorinhibitorinhibit

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ZNF207-IN-1

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