ARIH2 - ariadne RBR E3 ubiquitin protein ligase 2 Gene

Also Known as ARI2; TRIAD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10425

About ARIH2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,918,842-48,986,382 (from NCBI)

This gene has 31 transcripts (splice variants), 213 orthologues and 9 paralogues. Ubiquitous expression in thyroid (RPKM 18.6), heart (RPKM 17.4) and 25 other tissues.

Summary

The protein encoded by this gene is an E3 ubiquitin-protein Ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some Cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]

ARIH2 Products (25)

mRNA Protein Name
NM_001317333.2 NP_001304262.1 E3 ubiquitin-protein ligase ARIH2 isoform a
NM_001317334.2 NP_001304263.1 E3 ubiquitin-protein ligase ARIH2 isoform b
NM_001349209.2 NP_001336138.1 E3 ubiquitin-protein ligase ARIH2 isoform a
NM_001349210.2 NP_001336139.1 E3 ubiquitin-protein ligase ARIH2 isoform a
NM_001349211.2 NP_001336140.1 E3 ubiquitin-protein ligase ARIH2 isoform a
NM_001349212.2 NP_001336141.1 E3 ubiquitin-protein ligase ARIH2 isoform b
NM_001349213.2 NP_001336142.1 E3 ubiquitin-protein ligase ARIH2 isoform c
NM_001349214.2 NP_001336143.1 E3 ubiquitin-protein ligase ARIH2 isoform c
NM_001349215.2 NP_001336144.1 E3 ubiquitin-protein ligase ARIH2 isoform d
NM_001349216.2 NP_001336145.1 E3 ubiquitin-protein ligase ARIH2 isoform e precursor
NM_001349217.2 NP_001336146.1 E3 ubiquitin-protein ligase ARIH2 isoform f precursor
NM_001349218.2 NP_001336147.1 E3 ubiquitin-protein ligase ARIH2 isoform f precursor
NM_001349219.2 NP_001336148.1 E3 ubiquitin-protein ligase ARIH2 isoform f precursor
NM_001349220.2 NP_001336149.1 E3 ubiquitin-protein ligase ARIH2 isoform f precursor
NM_001349221.2 NP_001336150.1 E3 ubiquitin-protein ligase ARIH2 isoform f precursor
NM_001349222.2 NP_001336151.1 E3 ubiquitin-protein ligase ARIH2 isoform g
NM_001349223.2 NP_001336152.1 E3 ubiquitin-protein ligase ARIH2 isoform g
NM_001349224.2 NP_001336153.1 E3 ubiquitin-protein ligase ARIH2 isoform g
NM_001349225.2 NP_001336154.1 E3 ubiquitin-protein ligase ARIH2 isoform g
NM_001349226.2 NP_001336155.1 E3 ubiquitin-protein ligase ARIH2 isoform g
NM_001349227.2 NP_001336156.1 E3 ubiquitin-protein ligase ARIH2 isoform h
NM_001349228.2 NP_001336157.1 E3 ubiquitin-protein ligase ARIH2 isoform i
NM_001349229.2 NP_001336158.1 E3 ubiquitin-protein ligase ARIH2 isoform i
NM_001349230.2 NP_001336159.1 E3 ubiquitin-protein ligase ARIH2 isoform i
NM_006321.4 NP_006312.1 E3 ubiquitin-protein ligase ARIH2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16118314 GOA
enables ubiquitin conjugating enzyme binding IPI
IPI: Inferred from physical interaction
24076655 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
31253590 GOA
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
16118314 GOA
Biological Process GO Annotation Evidence References Source
involved in developmental cell growth IDA
IDA: Inferred from direct assay
19340006 GOA
involved in hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
16118314 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
31253590 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
16118314 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
19340006 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
16118314 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
24076655 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
16118314 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul5-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
24076655 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
19340006 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16118314 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARIH2 Protein Structure

IBR

IBR: IBR domain, a half RING-finger domain (208 - 270)

IBR

IBR: IBR domain, a half RING-finger domain (293 - 333)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 493 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase ARIH2

  • RING-type E3 ubiquitin transferase ARIH2

ARIH2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ARIH2 O95376 CUL5 Homo sapiens Q93034
Anti Bait CoIP
24076655
Intra
ARIH2 O95376 CUL5 Homo sapiens Q93034
Anti Tag CoIP
24076655
Intra
ARIH2 O95376 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
ARIH2 O95376 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
ARIH2 O95376 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
ARIH2 O95376 UBE2L6 Homo sapiens O14933
Y2H Array
25416956
Intra
ARIH2 O95376 UBE2L6 Homo sapiens O14933
Y2H Prey Pooling
25416956
Intra
ARIH2 O95376 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
ARIH2 O95376 TP53 Homo sapiens P04637
Y2H Pooling
16169070
Intra
ARIH2 O95376 TP53 Homo sapiens P04637
Pull Down
22819825
Intra
ARIH2 O95376 TP53 Homo sapiens P04637
Anti Tag CoIP
22819825
Intra
ARIH2 O95376 UBE2L3 Homo sapiens P68036
Validated Y2H
32296183
Intra
ARIH2 O95376 UBE2L3 Homo sapiens P68036
Y2H Array
32296183
Intra
ARIH2 O95376 UBE2L3 Homo sapiens P68036
Anti Bait CoIP
24076655
Intra
ARIH2 O95376 UBE2L3 Homo sapiens P68036
Anti Tag CoIP
24076655
Intra
ARIH2 O95376 UBE2L3 Homo sapiens P68036
Y2H Prey Pooling
32296183
Intra
ARIH2 O95376 UBE2L3 Homo sapiens P68036
Y2H
19549727
Intra
ARIH2 O95376 UBE2L3 Homo sapiens P68036
Y2H Pooling
16169070
Intra
ARIH2 O95376 UBE2L3 Homo sapiens P68036
Y2H Array
19549727
Intra
ARIH2 O95376 UGP2 Homo sapiens Q16851
Validated Y2H
25416956
Intra
ARIH2 O95376 UGP2 Homo sapiens Q16851
Validated Y2H
32296183
Intra
ARIH2 O95376 UGP2 Homo sapiens Q16851
Y2H Array
32296183
Intra
ARIH2 O95376 UGP2 Homo sapiens Q16851
Y2H Prey Pooling
32296183
Intra
ARIH2 O95376 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
ARIH2 O95376 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
ARIH2 O95376 PAX6 Homo sapiens P26367
Validated Y2H
32296183
Intra
ARIH2 O95376 CRX Homo sapiens O43186
Y2H Prey Pooling
32296183
Intra
ARIH2 O95376 CRX Homo sapiens O43186
Y2H Array
32296183
Intra
ARIH2 O95376 BUB1 Homo sapiens O43683
Y2H Prey Pooling
32296183
Intra
ARIH2 O95376 BUB1 Homo sapiens O43683
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00976 ARIH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARIH2 VGNC VGNC:38103
Rattus norvegicus ARIH2 RGD RGD:1305839
Felis catus ARIH2 VGNC VGNC:68189
Macaca mulatta ARIH2 VGNC VGNC:110385
Bos taurus ARIH2 VGNC VGNC:26134
Mus musculus ARIH2 MGD MGI:1344361
Others ARIH2 NCBI