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UGP2 - UDP-glucose pyrophosphorylase 2 Gene

Also Known as UDPG; UGP1; DEE83; UDPGP; UGPP1; UGPP2; EIEE83; SVUGP2; UDPGP2; pHC379

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7360

About UGP2

Cytogenetic location: 2p15 Genomic coordinates (GRCh38): 2:63,840,969-63,891,560 (from NCBI)

This gene has 39 transcripts (splice variants), 292 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in liver (RPKM 142.1), fat (RPKM 136.8) and 25 other tissues.

Summary

The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UGP2 Products (8)

mRNA	Protein	Name
NM_001001521.2	NP_001001521.1	UTP--glucose-1-phosphate uridylyltransferase isoform b
NM_001377524.1	NP_001364453.1	UTP--glucose-1-phosphate uridylyltransferase isoform b
NM_001377525.1	NP_001364454.1	UTP--glucose-1-phosphate uridylyltransferase isoform b
NM_001377526.1	NP_001364455.1	UTP--glucose-1-phosphate uridylyltransferase isoform c
NM_001377527.1	NP_001364456.1	UTP--glucose-1-phosphate uridylyltransferase isoform c
NM_001377528.1	NP_001364457.1	UTP--glucose-1-phosphate uridylyltransferase isoform c
NM_001377529.1	NP_001364458.1	UTP--glucose-1-phosphate uridylyltransferase isoform c
NM_006759.4	NP_006750.3	UTP--glucose-1-phosphate uridylyltransferase isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables UTP:glucose-1-phosphate uridylyltransferase activity	IDA IDA: Inferred from direct assay	22132858	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in UDP-glucose metabolic process	IDA IDA: Inferred from direct assay	8354390	GOA
involved in UDP-glucose metabolic process	IMP IMP: Inferred from mutant phenotype	31820119	GOA
involved in brain development	IMP IMP: Inferred from mutant phenotype	31820119	GOA
involved in glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	31820119	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UGP2 Protein Structure

UDPGP

0
100
200
300
400
508 a.a.

Protein Preferred Names	Protein Names
UTP--glucose-1-phosphate uridylyltransferase	UDP-glucose diphosphorylase

UGP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UGP2	Q16851	GLRX3	Homo sapiens	O76003	Validated Y2H	25416956
Intra	UGP2	Q16851	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
Intra	UGP2	Q16851	GRB2	Homo sapiens	P62993	Peptide Array	17474147
Intra	UGP2	Q16851	ARIH2	Homo sapiens	O95376	Y2H Prey Pooling	25416956
Intra	UGP2	Q16851	ARIH2	Homo sapiens	O95376	Y2H Array	25416956
Intra	UGP2	Q16851	ARIH2	Homo sapiens	O95376	Y2H Pooling	16189514
Intra	UGP2	Q16851	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Y2H	21988832
Intra	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Y2H Pooling	16189514
Intra	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Validated Y2H	32296183
Intra	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Y2H Array	25416956
Intra	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Y2H Array	32296183
Intra	UGP2	Q16851	UGP2	Homo sapiens	Q16851	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 83	DEE83 Epileptic Encephalopathy, Early Infantile, 83 Eiee83 Barakat-Perenthaler Syndrome Developmental And Epileptic Encephalopathy, 83 Early Infantile Epileptic Encephalopathy 83 Encephalopathy, Epileptic, Early Infantile, Type 83
Advanced Sleep Phase Syndrome, Familial, 3	Advanced Sleep Phase Syndrome 3 FASPS3 Familial Advanced Sleep Phase Syndrome 3 Sleep Phase Syndrome, Advanced, Familial, Type 3
Galactosemia I	Galactosemia Galt Deficiency Classic Galactosemia Galactose-1-Phosphate Uridylyltransferase Deficiency Galactose-1-Phosphate Uridyltransferase Deficiency GALAC1 Galactosemia, Classic Galactosemia Type 1 Galactosemias Classical Galactosemia Galactosaemia Galactose Intolerance Epimerase Deficiency Galactosemia Galactokinase Deficiency Disease Galactose Epimerase Deficiency Galactose-1-Phosphate Uridyl-Transferase Deficiency Disease Gale Deficiency Galk Deficiency Udp-Galactose-4-Epimerase Deficiency Disease Utp Hexose-1-Phosphate Uridylyltransferase Deficiency Galactosemia 1 Galactosemia, Duarte Variant Deficiency Of Galactokinase Udpglucose 4-Epimerase Deficiency Disease Classical Galactosaemia Galput Deficiency - [Galactose-4-Phosphate Uridyltransferase] Deficiency Classic Galactosaemia Deficiency Of Hexose-1-Phosphate Uridylyltransferase Deficiency Of Udpglucose-Hexose-1-Phosphate Uridylyltransferase Deficiency Of Galactose-1-Phosphate Uridylyltransferase Galactose-1-Phosphate Uridyl Transferase Deficiency Transferase Deficiency Galactosemia Deficiency Of Uridyl Transferase Deficiency Of Utp-Hexose-1-Phosphate Uridylyltransferase Utp-Hexose-1-Phosphate Uridyltransferase Deficiency
Galactosemia Iii	Galactose Epimerase Deficiency Gale Deficiency Udp-Galactose-4-Epimerase Deficiency Epimerase Deficiency Galactosemia Galactosemia Type 3 Gale-D Uridine Diphosphate Galactose-4-Epimerase Deficiency GALAC3 Galactosemia 3 Generalized Uridine Diphosphate Galactose-4-Epimerase Deficiency Erythrocyte Uridine Diphosphate Galactose-4-Epimerase Deficiency Galactosemia Type Iii Udp-Galactose-4'-Epimerase Deficiency Generalized Galactose Epimerase Deficiency Generalized Gale Deficiency Generalized Gale-D Generalized Udp-Galactose-4-Epimerase Deficiency Generalized Epimerase Deficiency Galactosemia Erythrocyte Galactose Epimerase Deficiency Erythrocyte Gale Deficiency Erythrocyte Gale-D Erythrocyte Udp-Galactose-4-Epimerase Deficiency Erythrocyte Epimerase Deficiency Galactosemia Galactosemias Classical Galactosemia Udpglucose 4-Epimerase Deficiency Disease
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15425	UGP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19970	Ugp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26473	Ugp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	UGP2	VGNC	VGNC:36651
Macaca mulatta	UGP2	VGNC	VGNC:78712
Felis catus	UGP2	VGNC	VGNC:66808
Rattus norvegicus	UGP2	RGD	RGD:1310210
Mus musculus	UGP2	MGD	MGI:2183447
Canis familiaris	UGP2	VGNC	VGNC:48120
Others	UGP2	NCBI