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CUL5 - cullin 5 Gene

Also Known as CUL-5; VACM1; VACM-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8065

About CUL5

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:108,008,898-108,107,761 (from NCBI)

This gene has 6 transcripts (splice variants), 263 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 9.9), kidney (RPKM 8.6) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to act upstream of or within cerebral cortex radially oriented cell migration and radial glia guided migration of Purkinje cell. Located in site of DNA damage. Part of Cul5-RING ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

CUL5 Products (1)

mRNA	Protein	Name
NM_003478.6	NP_003469.2	cullin-5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12504025	GOA
enables ubiquitin ligase complex scaffold activity	IDA IDA: Inferred from direct assay	22190037	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	17636018	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	21980433	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	27910872	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cul5-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	17636018	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	38418882	GOA
located in site of DNA damage	IDA IDA: Inferred from direct assay	28292928	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CUL5 Protein Structure

Cullin

Cullin_Nedd8

0
200
400
600
780 a.a.

Protein Preferred Names	Protein Names
cullin-5	Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1)

CUL5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CUL5	Q93034	ASB1	Homo sapiens	Q9Y576	TAP	21145461
Intra	CUL5	Q93034	ASB1	Homo sapiens	Q9Y576	Anti Tag CoIP	33961781
Intra	CUL5	Q93034	ASB1	Homo sapiens	Q9Y576	Anti Tag CoIP	28514442
Intra	CUL5	Q93034	ASB2	Homo sapiens	Q96Q27-2	Anti Tag CoIP	16325183
Intra	CUL5	Q93034	COG6	Homo sapiens	Q9Y2V7	Validated Y2H	32296183
Intra	CUL5	Q93034	COG6	Homo sapiens	Q9Y2V7	Y2H Prey Pooling	32296183
Intra	CUL5	Q93034	COG6	Homo sapiens	Q9Y2V7	Y2H Array	32296183
Intra	CUL5	Q93034	ASB7	Homo sapiens	Q9H672	Anti Tag CoIP	33961781
Intra	CUL5	Q93034	ASB7	Homo sapiens	Q9H672	TAP	21145461
Intra	CUL5	Q93034	RBX1	Homo sapiens	P62877	X-Ray Diffraction	18805092
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	Y2H Prey Pooling	32296183
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	Validated Y2H	32296183
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	Y2H	21516116
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	Y2H Array	32296183
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	Y2H Prey Pooling	25416956
Intra	CUL5	Q93034	RNF7	Homo sapiens	Q9UBF6	TAP	21145461
Intra	CUL5	Q93034	SOCS2	Homo sapiens	O14508	TAP	21145461
Intra	CUL5	Q93034	SOCS2	Homo sapiens	O14508	Anti Tag CoIP	33961781
Intra	CUL5	Q93034	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	CUL5	Q93034	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	CUL5	Q93034	ASB6	Homo sapiens	Q9NWX5	TAP	21145461
Intra	CUL5	Q93034	ASB6	Homo sapiens	Q9NWX5	Anti Tag CoIP	33961781
Intra	CUL5	Q93034	ARIH2	Homo sapiens	O95376	Anti Tag CoIP	33961781
Intra	CUL5	Q93034	ARIH2	Homo sapiens	O95376	Anti Bait CoIP	24076655
Intra	CUL5	Q93034	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Prey Pooling	32296183
Intra	CUL5	Q93034	CCNB1IP1	Homo sapiens	Q9NPC3	Validated Y2H	32296183
Intra	CUL5	Q93034	CCNB1IP1	Homo sapiens	Q9NPC3	Y2H Array	32296183
Intra	CUL5	Q93034	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	25416956
Intra	CUL5	Q93034	CCNDBP1	Homo sapiens	O95273	Y2H Array	31515488
Intra	CUL5	Q93034	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
Intra	CUL5	Q93034	KANK4	Homo sapiens	Q5T7N3	Y2H Array	32296183
Intra	CUL5	Q93034	KANK4	Homo sapiens	Q5T7N3	Y2H Prey Pooling	32296183
Cross	CUL5	Q93034	vif	Human immunodeficiency virus	P12504	GMS	24402281
Cross	CUL5	Q93034	vif	Human immunodeficiency virus	P12504	Ion Exchange Chrom	24402281
Cross	CUL5	Q93034	vif	Human immunodeficiency virus	P12504	X-Ray Diffraction	24402281
Cross	CUL5	Q93034	vif	Human immunodeficiency virus	P12504	Pull Down	24402281

Cross: Cross-species interaction Intra: Intraspecies interaction

CUL5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82840	Cullin 5 Antibody (YA2585)	WB	Human, Mouse, Rat
HY-P82840A	Cullin 5 Antibody (YA2585)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Molluscum Contagiosum	Water Warts Molluscum Verrucosum
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Three M Syndrome 1	3-M Syndrome Yakut Short Stature Syndrome 3m Syndrome Le Merrer Syndrome Dolichospondylic Dysplasia Gloomy Face Syndrome Three M Syndrome 3M1 3m Syndrome 1 Miller-Mckusick-Malvaux Syndrome 3-Msbn Three-M Slender-Boned Nanism Miller-Mckusick-Malvaux-Syndrome 3-M Syndrome 1 3m Syndrome-1 3m Syndrome, Type 1 Dwarfism Dwarfism Tall Vertebrae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03364	CUL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20711	Cul5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27222	Cul5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CUL5	MGD	MGI:1922967
Macaca mulatta	CUL5	VGNC	VGNC:71570
Bos taurus	CUL5	VGNC	VGNC:27834
Rattus norvegicus	CUL5	RGD	RGD:621742
Felis catus	CUL5	VGNC	VGNC:61286
Canis familiaris	CUL5	VGNC	VGNC:39733
Others	CUL5	NCBI