ASB1 - ankyrin repeat and SOCS box containing 1 Gene

Homo sapiens

Also known as ASB-1

Gene ID: 51665 | Gene type: protein coding

About ASB1

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:238,426,927-238,452,250 (from NCBI)

This gene has 9 transcripts (splice variants), 193 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 9.2), heart (RPKM 8.5) and 25 other tissues.

Summary

The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016]

ASB1 Products(2)

mRNA	Protein	Name
NM_001040445.3	NP_001035535.1	ankyrin repeat and SOCS box protein 1 isoform 1
NM_001330196.2	NP_001317125.1	ankyrin repeat and SOCS box protein 1 isoform 2

ASB1 Protein Structure

Ank_2

SOCS_box

0
100
200
300
335 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and SOCS box protein 1

Related Diseases

Diseases

Alias

Atrial Septal Defect 1

ASD1	Atrial Heart Septal Defect 1
Asd

Ebstein Anomaly

Ebstein'S Anomaly	Ebstein'S Anomaly Of Common Atrioventricular Valve
Ebstein'S Anomaly Of Right Atrioventricular Valve	Ebstein'S Anomaly Of Tricuspid Valve
Ebstein'S Malformation	Ebstein Malformation Of The Tricuspid Valve
Ebstein Anomaly Of The Tricuspid Valve	Ebstein Disease
Accessory Tricuspid Valve Tissue	Congenital Ebstein Deformity Of Tricuspid Valve
Ebstein Syndrome	Ebstein Cardiopathy
Ebstein Anomaly Of Tricuspid Valve

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01058	ASB1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ASB1	VGNC	VGNC:26186
Felis catus	ASB1	VGNC	VGNC:59955
Mus musculus	ASB1	MGD	MGI:1929735
Macaca mulatta	ASB1	VGNC	VGNC:69839
Rattus norvegicus	ASB1	RGD	RGD:1310760
Others	ASB1	NCBI