YWHAG - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma Gene

Homo sapiens

Also known as DEE56; EIEE56; PPP1R170; 14-3-3GAMMA

Gene ID: 7532 | Gene type: protein coding

About YWHAG

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:76,326,799-76,358,991 (from NCBI)

This gene has 1 transcript (splice variant), 279 orthologues, 6 paralogues and is associated with 3 phenotypes. Broad expression in brain (RPKM 260.6), fat (RPKM 131.1) and 22 other tissues.

Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both Plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

YWHAG Products(1)

mRNA	Protein	Name
NM_012479.4	NP_036611.2	2014/3/3 protein gamma

YWHAG Protein Structure

14-3-3

0
100
200
247 a.a.

Protein Preferred Names

Protein Names

14-3-3 protein gamma

KCIP-1

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 56

DEE56	Epileptic Encephalopathy, Early Infantile, 56
Eiee56	Developmental And Epileptic Encephalopathy, 56
Early Infantile Epileptic Encephalopathy 56

Constipation

Spasticity

Specific Learning Disability

Specific Learning Difficulty

Specific Learning Disorder

Hypotonia

Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy	Non-Specific Eoee
Undetermined Eoee

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15942	YWHAG Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	YWHAG	VGNC	VGNC:48509
Rattus norvegicus	YWHAG	RGD	RGD:62002
Bos taurus	YWHAG	VGNC	VGNC:37046
Mus musculus	YWHAG	MGD	MGI:108109
Macaca mulatta	YWHAG	VGNC	VGNC:78820
Felis catus	YWHAG	VGNC	VGNC:67155

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