TNFAIP3 - TNF alpha induced protein 3 Gene
Also Known as A20; AISBL; AIFBL1; OTUD7C; TNFA1P2
Species: Homo sapiens
About TNFAIP3
This gene has 8 transcripts (splice variants), 204 orthologues, 2 paralogues and is associated with 99 phenotypes. Broad expression in bone marrow (RPKM 156.2), appendix (RPKM 61.9) and 14 other tissues.
Summary
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a Zinc Finger Protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated Apoptosis. The encoded protein, which has both ubiquitin Ligase and Deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
TNFAIP3 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001270507.2 | NP_001257436.1 | tumor necrosis factor alpha-induced protein 3 |
| NM_001270508.2 | NP_001257437.1 | tumor necrosis factor alpha-induced protein 3 |
| NM_006290.4 | NP_006281.1 | tumor necrosis factor alpha-induced protein 3 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables K63-linked deubiquitinase activity |
EXP
EXP: Inferred from Experiment
|
14748687 | GOA |
| enables cysteine-type deubiquitinase activity |
IDA
IDA: Inferred from direct assay
|
15258597 | GOA |
| enables cysteine-type deubiquitinase activity |
IMP
IMP: Inferred from mutant phenotype
|
15258597 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| enables protease binding |
IPI
IPI: Inferred from physical interaction
|
18223652 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9299557 | GOA |
| enables ubiquitin binding |
IPI
IPI: Inferred from physical interaction
|
19285159 | GOA |
| enables ubiquitin-protein transferase activity |
IDA
IDA: Inferred from direct assay
|
15258597 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
11463333 | GOA |
TNFAIP3 Protein Structure
OTU: OTU-like cysteine protease (98 - 257)
zf-A20: A20-like zinc finger (385 - 408)
zf-A20: A20-like zinc finger (475 - 500)
zf-A20: A20-like zinc finger (605 - 628)
zf-A20: A20-like zinc finger (655 - 678)
zf-A20: A20-like zinc finger (714 - 738)
zf-A20: A20-like zinc finger (759 - 784)
- 0
- 200
- 400
- 600
- 790 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
tumor necrosis factor alpha-induced protein 3 |
|
TNFAIP3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
TNFAIP3 | P21580 | PIBF1 | Homo sapiens | Q4G0R1 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | ARRDC3 | Homo sapiens | Q96B67 | 25416956 | |
|
Intra
|
TNFAIP3 | P21580 | ARRDC3 | Homo sapiens | Q96B67 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | ARRDC3 | Homo sapiens | Q96B67 | 25416956 | |
|
Intra
|
TNFAIP3 | P21580 | ARRDC3 | Homo sapiens | Q96B67 | 25416956 | |
|
Intra
|
TNFAIP3 | P21580 | TRAF2 | Homo sapiens | Q12933 | 31515488 | |
|
Intra
|
TNFAIP3 | P21580 | TRAF2 | Homo sapiens | Q12933 | 25416956 | |
|
Intra
|
TNFAIP3 | P21580 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TRAF2 | Homo sapiens | Q12933 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TRAF2 | Homo sapiens | Q12933 | 30561431 | |
|
Intra
|
TNFAIP3 | P21580 | YWHAE | Homo sapiens | P62258 | 21988832 | |
|
Intra
|
TNFAIP3 | P21580 | YWHAE | Homo sapiens | P62258 | 36931259 | |
|
Intra
|
TNFAIP3 | P21580 | TNIP1 | Homo sapiens | Q15025 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TNIP1 | Homo sapiens | Q15025 | 30561431 | |
|
Intra
|
TNFAIP3 | P21580 | TNIP1 | Homo sapiens | Q15025 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TNIP1 | Homo sapiens | Q15025 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TNIP1 | Homo sapiens | Q15025 | 25416956 | |
|
Intra
|
TNFAIP3 | P21580 | TNIP1 | Homo sapiens | Q15025 | 31515488 | |
|
Intra
|
TNFAIP3 | P21580 | TNIP1 | Homo sapiens | Q15025 | 25416956 | |
|
Intra
|
TNFAIP3 | P21580 | TNIP2 | Homo sapiens | Q8NFZ5 | 30561431 | |
|
Intra
|
TNFAIP3 | P21580 | YWHAG | Homo sapiens | P61981 | 36931259 | |
|
Intra
|
TNFAIP3 | P21580 | RNF11 | Homo sapiens | Q9Y3C5 | 15231748 | |
|
Cross
|
TNFAIP3 | P21580 | Ywhah | Mus musculus | P68510 | 9299557 | |
|
Intra
|
TNFAIP3 | P21580 | TNFAIP3 | Homo sapiens | P21580 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TNFAIP3 | Homo sapiens | P21580 | 25416956 | |
|
Intra
|
TNFAIP3 | P21580 | TNFAIP3 | Homo sapiens | P21580 | 25502805 | |
|
Intra
|
TNFAIP3 | P21580 | TNFAIP3 | Homo sapiens | P21580 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TNFAIP3 | Homo sapiens | P21580 | 30561431 | |
|
Intra
|
TNFAIP3 | P21580 | TNFAIP3 | Homo sapiens | P21580 | 31515488 | |
|
Intra
|
TNFAIP3 | P21580 | TNFAIP3 | Homo sapiens | P21580 | 11389905 | |
|
Intra
|
TNFAIP3 | P21580 | TNFAIP3 | Homo sapiens | P21580 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TAX1BP1 | Homo sapiens | Q86VP1 | 30561431 | |
|
Intra
|
TNFAIP3 | P21580 | TAX1BP1 | Homo sapiens | Q86VP1 | 11389905 | |
|
Intra
|
TNFAIP3 | P21580 | TAX1BP1 | Homo sapiens | Q86VP1 | 33961781 | |
|
Intra
|
TNFAIP3 | P21580 | TAX1BP1 | Homo sapiens | Q86VP1 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | RNF216 | Homo sapiens | Q9NWF9 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | RNF216 | Homo sapiens | Q9NWF9 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | RNF216 | Homo sapiens | Q9NWF9 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TRIM23 | Homo sapiens | P36406 | 25416956 | |
|
Intra
|
TNFAIP3 | P21580 | TRIM23 | Homo sapiens | P36406 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TRIM23 | Homo sapiens | P36406 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | TRIM23 | Homo sapiens | P36406 | 25416956 | |
|
Intra
|
TNFAIP3 | P21580 | TRIM23 | Homo sapiens | P36406 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | RAD23A | Homo sapiens | P54725 | 32296183 | |
|
Intra
|
TNFAIP3 | P21580 | CASP8 | Homo sapiens | Q14790 | 19060883 | |
|
Intra
|
TNFAIP3 | P21580 | IKBKG | Homo sapiens | Q9Y6K9 | 21988832 |
TNFAIP3 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82486 | TNFAIP3 Antibody (YA2231) | WB, IHC-F, IHC-P, ICC/IF | Human |
| HY-P82486A | TNFAIP3 Antibody (YA2231)(PBS only) | WB, IHC-F, IHC-P, ICC/IF | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Autoinflammatory Syndrome, Familial, Behcet-Like 1 |
|
|
| Familial Behcet-Like Autoinflammatory Syndrome |
|
|
| Iridocyclitis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Autoimmune Lymphoproliferative Syndrome |
|
|
| Scleritis |
|
|
| Autoinflammation, Panniculitis, And Dermatosis Syndrome |
|
|
| Lymphoproliferative Syndrome |
|
|
| Takayasu Arteritis |
|
|
| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
|
| Alzheimer Disease 5 |
|
|
| Primary Mediastinal B-Cell Lymphoma |
|
|
| Aphthous Stomatitis |
|
|
| Marginal Zone B-Cell Lymphoma |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Nodal Marginal Zone Lymphoma |
|
|
| Spleen Cancer |
|
|
| Splenic Marginal Zone Lymphoma |
|
|
| Autoimmune Disease |
|
|
| Glycogen Storage Disease Iv |
|
|
| Lymphoma, Mucosa-Associated Lymphoid Type |
|
|
| Psoriasis |
|
|
| Autoimmune Disease Of Cardiovascular System |
|
|
| Behcet Syndrome |
|
|
| Potocki-Shaffer Syndrome |
|
|
| Heart Disease |
|
|
| Celiac Disease 1 |
|
|
| Noonan Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | TNFAIP3 | VGNC | VGNC:78580 |
| Rattus norvegicus | TNFAIP3 | RGD | RGD:1589275 |
| Bos taurus | TNFAIP3 | VGNC | VGNC:36155 |
| Mus musculus | TNFAIP3 | MGD | MGI:1196377 |
| Canis familiaris | TNFAIP3 | VGNC | VGNC:47650 |
| Felis catus | TNFAIP3 | VGNC | VGNC:66398 |
| Others | TNFAIP3 | NCBI |