TNIP1 - TNFAIP3 interacting protein 1 Gene

Also Known as VAN; NAF1; ABIN-1; nip40-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10318

About TNIP1

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:151,029,943-151,087,685 (from NCBI)

This gene has 21 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 55.9), spleen (RPKM 36.4) and 25 other tissues.

Summary

This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

TNIP1 Products (12)

mRNA	Protein	Name
NM_001252385.2	NP_001239314.1	TNFAIP3-interacting protein 1 isoform 1
NM_001252386.2	NP_001239315.1	TNFAIP3-interacting protein 1 isoform 2
NM_001252390.2	NP_001239319.1	TNFAIP3-interacting protein 1 isoform 3
NM_001252391.2	NP_001239320.1	TNFAIP3-interacting protein 1 isoform 3
NM_001252392.2	NP_001239321.1	TNFAIP3-interacting protein 1 isoform 4
NM_001252393.2	NP_001239322.1	TNFAIP3-interacting protein 1 isoform 4
NM_001258454.2	NP_001245383.1	TNFAIP3-interacting protein 1 isoform 3
NM_001258455.1	NP_001245384.1	TNFAIP3-interacting protein 1 isoform 5
NM_001258456.1	NP_001245385.1	TNFAIP3-interacting protein 1 isoform 6
NM_001364486.2	NP_001351415.1	TNFAIP3-interacting protein 1 isoform 7
NM_001364487.2	NP_001351416.1	TNFAIP3-interacting protein 1 isoform 5
NM_006058.5	NP_006049.3	TNFAIP3-interacting protein 1 isoform 3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	21988832	GOA
enables mitogen-activated protein kinase binding	IDA IDA: Inferred from direct assay	12220502	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15474016	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in glycoprotein biosynthetic process	IDA IDA: Inferred from direct assay	9923610	GOA
involved in leukocyte cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	17632516	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	12220502	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	16684768	GOA
involved in positive regulation of protein deubiquitination	IDA IDA: Inferred from direct assay	16684768	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
TNFAIP3-interacting protein 1	A20-binding inhibitor of NF-kappa-B activation 1

TNIP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNIP1	Q15025	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	TNIP1	Q15025	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	TNIP1	Q15025	KRTAP19-7	Homo sapiens	Q3SYF9	Validated Y2H	32296183
Intra	TNIP1	Q15025	SYT6	Homo sapiens	Q5T7P8-2	Y2H Array	25416956
Intra	TNIP1	Q15025	SYT6	Homo sapiens	Q5T7P8-2	Validated Y2H	25416956
Intra	TNIP1	Q15025	KRTAP8-1	Homo sapiens	Q8IUC2	Validated Y2H	32296183
Intra	TNIP1	Q15025	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Array	32296183
Intra	TNIP1	Q15025	KRTAP8-1	Homo sapiens	Q8IUC2	Y2H Prey Pooling	32296183
Intra	TNIP1	Q15025	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	TNIP1	Q15025	GIT2	Homo sapiens	Q14161	Y2H	21988832
Intra	TNIP1	Q15025	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	TNIP1	Q15025	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	TNIP1	Q15025	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	32296183
Intra	TNIP1	Q15025	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	TNIP1	Q15025	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	TNIP1	Q15025	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	TNIP1	Q15025	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	TNIP1	Q15025	TTF2	Homo sapiens	Q9UNY4-2	Validated Y2H	32296183
Intra	TNIP1	Q15025	KRTAP19-3	Homo sapiens	Q7Z4W3	Validated Y2H	32296183
Intra	TNIP1	Q15025	KRTAP6-1	Homo sapiens	Q3LI64	Validated Y2H	32296183
Intra	TNIP1	Q15025	TTC39A	Homo sapiens	Q5SRH9-6	Validated Y2H	32296183
Intra	TNIP1	Q15025	PIBF1	Homo sapiens	Q4G0R1	Validated Y2H	32296183
Intra	TNIP1	Q15025	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	TNIP1	Q15025	KIFC3	Homo sapiens	Q9BVG8	Validated Y2H	25416956
Intra	TNIP1	Q15025	KIFC3	Homo sapiens	Q9BVG8	Y2H Array	25416956
Intra	TNIP1	Q15025	EHHADH	Homo sapiens	Q08426	Y2H Array	25416956
Intra	TNIP1	Q15025	EHHADH	Homo sapiens	Q08426	Y2H Array	31515488
Intra	TNIP1	Q15025	TNIP3	Homo sapiens	Q96KP6	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	TNIP3	Homo sapiens	Q96KP6	Validated Y2H	32296183
Intra	TNIP1	Q15025	MOB1B	Homo sapiens	Q7L9L4	Validated Y2H	25416956
Intra	TNIP1	Q15025	MOB1B	Homo sapiens	Q7L9L4	Y2H Array	25416956
Intra	TNIP1	Q15025	NIFK	Homo sapiens	Q9BYG3	Validated Y2H	25416956
Intra	TNIP1	Q15025	NIFK	Homo sapiens	Q9BYG3	Y2H Array	25416956
Intra	TNIP1	Q15025	MAP1LC3C	Homo sapiens	Q9BXW4	Validated Y2H	32296183
Intra	TNIP1	Q15025	ZMAT2	Homo sapiens	Q96NC0	Validated Y2H	32296183
Intra	TNIP1	Q15025	CDIP1	Homo sapiens	Q9H305	Y2H Array	25416956
Intra	TNIP1	Q15025	CDIP1	Homo sapiens	Q9H305	Y2H	21516116
Intra	TNIP1	Q15025	CDC37	Homo sapiens	Q16543	Validated Y2H	32296183
Intra	TNIP1	Q15025	NFKB1	Homo sapiens	P19838	Anti Tag CoIP	33961781
Intra	TNIP1	Q15025	TSG101	Homo sapiens	Q99816	Anti Tag CoIP	33961781
Intra	TNIP1	Q15025	TSG101	Homo sapiens	Q99816	Validated Y2H	32296183
Intra	TNIP1	Q15025	ZNHIT1	Homo sapiens	O43257	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	ZNHIT1	Homo sapiens	O43257	Validated Y2H	25416956
Intra	TNIP1	Q15025	ZNHIT1	Homo sapiens	O43257	Y2H Array	25416956
Intra	TNIP1	Q15025	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	TNIP1	Q15025	OPTN	Homo sapiens	Q96CV9	Anti Tag CoIP	33961781
Intra	TNIP1	Q15025	OPTN	Homo sapiens	Q96CV9	Y2H	21516116
Intra	TNIP1	Q15025	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32296183
Intra	TNIP1	Q15025	OPTN	Homo sapiens	Q96CV9	Y2H Fragment Pooling	23414517
Intra	TNIP1	Q15025	OPTN	Homo sapiens	Q96CV9	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	OPTN	Homo sapiens	Q96CV9	ViroTrap	30561431
Intra	TNIP1	Q15025	OPTN	Homo sapiens	Q96CV9	Y2H Array	25416956
Intra	TNIP1	Q15025	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	TXLNA	Homo sapiens	P40222	Validated Y2H	25416956
Intra	TNIP1	Q15025	TXLNA	Homo sapiens	P40222	Y2H Array	25416956
Intra	TNIP1	Q15025	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	MAP1LC3B	Homo sapiens	Q9GZQ8	Y2H Array	25416956
Intra	TNIP1	Q15025	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	TNIP1	Q15025	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	TNIP1	Q15025	GTF2B	Homo sapiens	Q00403	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	CCNG1	Homo sapiens	P51959	Y2H Array	25416956
Intra	TNIP1	Q15025	CCNG1	Homo sapiens	P51959	Validated Y2H	25416956
Intra	TNIP1	Q15025	CCNG1	Homo sapiens	P51959	Y2H	21516116
Intra	TNIP1	Q15025	CCNG1	Homo sapiens	P51959	Y2H	21988832
Intra	TNIP1	Q15025	CDC23	Homo sapiens	Q9UJX2	Validated Y2H	32296183
Intra	TNIP1	Q15025	MORF4L1	Homo sapiens	Q9UBU8	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	MORF4L1	Homo sapiens	Q9UBU8	Validated Y2H	25416956
Intra	TNIP1	Q15025	MORF4L1	Homo sapiens	Q9UBU8	Y2H Array	25416956
Intra	TNIP1	Q15025	MORF4L2	Homo sapiens	Q15014	Validated Y2H	25416956
Intra	TNIP1	Q15025	MORF4L2	Homo sapiens	Q15014	Y2H Array	25416956
Intra	TNIP1	Q15025	TNFAIP3	Homo sapiens	P21580	ViroTrap	30561431
Intra	TNIP1	Q15025	TNFAIP3	Homo sapiens	P21580	Y2H	21988832
Intra	TNIP1	Q15025	TNFAIP3	Homo sapiens	P21580	Y2H Array	25416956
Intra	TNIP1	Q15025	TNFAIP3	Homo sapiens	P21580	CoIP	11389905
Intra	TNIP1	Q15025	TAX1BP1	Homo sapiens	Q86VP1	Y2H Prey Pooling	32296183
Intra	TNIP1	Q15025	TAX1BP1	Homo sapiens	Q86VP1	Validated Y2H	32296183
Intra	TNIP1	Q15025	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	25416956
Intra	TNIP1	Q15025	TAX1BP1	Homo sapiens	Q86VP1	Y2H Array	32296183
Intra	TNIP1	Q15025	TAX1BP1	Homo sapiens	Q86VP1	ViroTrap	30561431
Intra	TNIP1	Q15025	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	25416956
Intra	TNIP1	Q15025	TCEANC2	Homo sapiens	Q96MN5	Y2H Array	25416956
Intra	TNIP1	Q15025	TCEANC2	Homo sapiens	Q96MN5	Y2H Prey Pooling	25416956
Cross	TNIP1	Q15025	ipaH9.8	Shigella flexneri	Q8VSC3	Y2H	20010814
Cross	TNIP1	Q15025	ipaH9.8	Shigella flexneri	Q8VSC3	Anti Tag CoIP	20010814
Intra	TNIP1	Q15025	TCEA2	Homo sapiens	Q15560	Y2H Array	32296183
Intra	TNIP1	Q15025	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
Intra	TNIP1	Q15025	DPPA4	Homo sapiens	Q7L190	Validated Y2H	32296183
Intra	TNIP1	Q15025	PIN1	Homo sapiens	Q13526	Validated Y2H	25416956
Intra	TNIP1	Q15025	PIN1	Homo sapiens	Q13526	Y2H Array	25416956
Intra	TNIP1	Q15025	PIN1	Homo sapiens	Q13526	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	C8orf33	Homo sapiens	Q9H7E9	Validated Y2H	32296183
Intra	TNIP1	Q15025	NDC80	Homo sapiens	O14777	Y2H Array	31515488
Intra	TNIP1	Q15025	NDC80	Homo sapiens	O14777	Y2H Array	29892012
Intra	TNIP1	Q15025	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	FAM161A	Homo sapiens	Q3B820	Validated Y2H	32296183
Intra	TNIP1	Q15025	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	TNIP1	Q15025	GABARAPL2	Homo sapiens	P60520	Validated Y2H	25416956
Intra	TNIP1	Q15025	GABARAPL2	Homo sapiens	P60520	Y2H Array	25416956
Intra	TNIP1	Q15025	MAP1LC3A	Homo sapiens	Q9H492	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	MAP1LC3A	Homo sapiens	Q9H492	Validated Y2H	32296183
Intra	TNIP1	Q15025	MAP1LC3A	Homo sapiens	Q9H492	Y2H Array	25416956
Intra	TNIP1	Q15025	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
Intra	TNIP1	Q15025	LITAF	Homo sapiens	Q99732	Validated Y2H	32296183
Intra	TNIP1	Q15025	LENG8	Homo sapiens	Q96PV6	Validated Y2H	32296183
Intra	TNIP1	Q15025	ZBTB25	Homo sapiens	P24278	Y2H Array	25416956
Intra	TNIP1	Q15025	MAGEB18	Homo sapiens	Q96M61	Y2H Pooling	16189514
Intra	TNIP1	Q15025	MAGEB18	Homo sapiens	Q96M61	Validated Y2H	25416956
Intra	TNIP1	Q15025	MAGEB18	Homo sapiens	Q96M61	Pull Down	16189514
Intra	TNIP1	Q15025	SPATA2	Homo sapiens	Q9UM82	Validated Y2H	32296183
Intra	TNIP1	Q15025	SPATA2	Homo sapiens	Q9UM82	Y2H Prey Pooling	32296183
Intra	TNIP1	Q15025	SPATA2	Homo sapiens	Q9UM82	Y2H Array	32296183
Intra	TNIP1	Q15025	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	25416956
Intra	TNIP1	Q15025	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	TNIP1	Q15025	NME7	Homo sapiens	Q9Y5B8	Y2H	21516116
Intra	TNIP1	Q15025	NME7	Homo sapiens	Q9Y5B8	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	NME7	Homo sapiens	Q9Y5B8	Y2H	21988832
Intra	TNIP1	Q15025	CCDC112	Homo sapiens	Q8NEF3	Validated Y2H	25416956
Intra	TNIP1	Q15025	CCDC112	Homo sapiens	Q8NEF3	Y2H Array	25416956
Intra	TNIP1	Q15025	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	25416956
Intra	TNIP1	Q15025	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	32296183
Intra	TNIP1	Q15025	VPS33B	Homo sapiens	Q9H267	Validated Y2H	25416956
Intra	TNIP1	Q15025	VPS33B	Homo sapiens	Q9H267	Validated Y2H	32296183
Intra	TNIP1	Q15025	VPS33B	Homo sapiens	Q9H267	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	RALBP1	Homo sapiens	Q15311	Y2H Array	25416956
Intra	TNIP1	Q15025	SNIP1	Homo sapiens	Q8TAD8	Y2H Array	25416956
Intra	TNIP1	Q15025	HDDC3	Homo sapiens	Q8N4P3	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	HDDC3	Homo sapiens	Q8N4P3	Validated Y2H	25416956
Intra	TNIP1	Q15025	HDDC3	Homo sapiens	Q8N4P3	Y2H Array	25416956
Intra	TNIP1	Q15025	FAM168A	Homo sapiens	Q92567	Y2H Prey Pooling	25416956
Intra	TNIP1	Q15025	FAM168A	Homo sapiens	Q92567	Validated Y2H	25416956
Intra	TNIP1	Q15025	FAM168A	Homo sapiens	Q92567	Y2H Array	25416956
Intra	TNIP1	Q15025	IKBKG	Homo sapiens	Q9Y6K9	Y2H	21988832
Intra	TNIP1	Q15025	MOB3C	Homo sapiens	Q70IA8	Y2H Array	25416956
Intra	TNIP1	Q15025	MOB3C	Homo sapiens	Q70IA8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Psoriasis 14, Pustular	Generalized Pustular Psoriasis Gpp Ditra Acrodermatitis Continua Of Hallopeau Palmoplantar Pustulosis PSORS14 Interleukin 36 Receptor Antagonist Deficiency Psorp Pustular Psoriasis 14 Deficiency Of Il-36r Antagonist Acute Generalised Pustular Psoriasis Deficiency Of The Interleukin-36 Receptor Antagonist Generalized Pustular Psoriasis Of Von Zumbusch Von Zumbusch Psoriasis Deficiency Of Il-36ra Psoriasis, Pustular, Generalized Psoriasis, Pustular, Type 14 Pustulosis Of Palms And Soles Acute Generalized Pustular Psoriasis Palmoplantar Pustular Psoriasis Pustulosis Palmaris Et Plantaris Ppp - [Palmoplantar Pustulosis] Pustular Psoriasis Of The Palms And Soles Pustular Bacterid
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14834	TNIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNIP1	VGNC	VGNC:79057
Bos taurus	TNIP1	VGNC	VGNC:36180
Canis familiaris	TNIP1	VGNC	VGNC:47676
Rattus norvegicus	TNIP1	RGD	RGD:1309380
Mus musculus	TNIP1	MGD	MGI:1926194
Felis catus	TNIP1	VGNC	VGNC:66416
Others	TNIP1	NCBI