ZMAT2 - zinc finger matrin-type 2 Gene

Also Known as Snu23; Ptg-12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 153527

About ZMAT2

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,700,447-140,706,686 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 45.9), fat (RPKM 34.0) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and zinc ion binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleus. Part of U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Apr 2022]

ZMAT2 Products (1)

mRNA Protein Name
NM_144723.3 NP_653324.1 zinc finger matrin-type protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20195357 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
Cellular Component GO Annotation Evidence References Source
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28781166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMAT2 Protein Structure

zf-C2H2_jaz

zf-C2H2_jaz: Zinc-finger double-stranded RNA-binding (80 - 105)

  • 0
  • 100
  • 199 a.a.
Protein Preferred Names Protein Names

zinc finger matrin-type protein 2

ZMAT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZMAT2 Q96NC0 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
ZMAT2 Q96NC0 ZBTB14 Homo sapiens O43829
Validated Y2H
25416956
Intra
ZMAT2 Q96NC0 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 PSEN1 Homo sapiens P49768-2
Y2H Array
32814053
Intra
ZMAT2 Q96NC0 PSEN1 Homo sapiens P49768-2
Validated Y2H
32814053
Intra
ZMAT2 Q96NC0 PSEN1 Homo sapiens P49768-2
Y2H Pooling
32814053
Intra
ZMAT2 Q96NC0 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 TFIP11 Homo sapiens Q9UBB9
Y2H Array
31515488
Intra
ZMAT2 Q96NC0 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 PSEN2 Homo sapiens P49810
Y2H Pooling
32814053
Intra
ZMAT2 Q96NC0 PSEN2 Homo sapiens P49810
Validated Y2H
32814053
Intra
ZMAT2 Q96NC0 PSEN2 Homo sapiens P49810
Y2H Array
32814053
Intra
ZMAT2 Q96NC0 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
ZMAT2 Q96NC0 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
ZMAT2 Q96NC0 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
ZMAT2 Q96NC0 TRIM36 Homo sapiens Q9NQ86
Y2H Array
25416956
Intra
ZMAT2 Q96NC0 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
25416956
Intra
ZMAT2 Q96NC0 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 VPS52 Homo sapiens Q8N1B4
Validated Y2H
25416956
Intra
ZMAT2 Q96NC0 CCDC57 Homo sapiens Q2TAC2
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 CCDC57 Homo sapiens Q2TAC2
Y2H Array
25416956
Intra
ZMAT2 Q96NC0 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 TRAF2 Homo sapiens Q12933
Y2H Array
25416956
Intra
ZMAT2 Q96NC0 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra
ZMAT2 Q96NC0 TNIP1 Homo sapiens Q15025
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 SPAG5 Homo sapiens Q96R06
Y2H Array
25416956
Intra
ZMAT2 Q96NC0 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
ZMAT2 Q96NC0 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
ZMAT2 Q96NC0 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
ZMAT2 Q96NC0 FSD2 Homo sapiens A1L4K1
Validated Y2H
25416956
Intra
ZMAT2 Q96NC0 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
ZMAT2 Q96NC0 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 HAP1 Homo sapiens P54257
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 HAP1 Homo sapiens P54257
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 PHC2 Homo sapiens Q8IXK0
Y2H Array
25416956
Intra
ZMAT2 Q96NC0 PHC2 Homo sapiens Q8IXK0
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 NDRG1 Homo sapiens Q92597
Validated Y2H
32814053
Intra
ZMAT2 Q96NC0 NDRG1 Homo sapiens Q92597
Y2H Array
32814053
Intra
ZMAT2 Q96NC0 NDRG1 Homo sapiens Q92597
Y2H Pooling
32814053
Intra
ZMAT2 Q96NC0 GRIPAP1 Homo sapiens Q4V328
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 GRIPAP1 Homo sapiens Q4V328
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 FXR2 Homo sapiens P51116
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 FXR2 Homo sapiens P51116
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 LZTS2 Homo sapiens Q9BRK4
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 TRIM37 Homo sapiens O94972
Validated Y2H
25416956
Intra
ZMAT2 Q96NC0 TRIM37 Homo sapiens O94972
Y2H Array
25416956
Intra
ZMAT2 Q96NC0 ZBTB8A Homo sapiens Q96BR9
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 IKZF1 Homo sapiens Q13422
Validated Y2H
25416956
Intra
ZMAT2 Q96NC0 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
ZMAT2 Q96NC0 OPTN Homo sapiens Q96CV9
Display Tech
20195357
Intra
ZMAT2 Q96NC0 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
ZMAT2 Q96NC0 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
ZMAT2 Q96NC0 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
ZMAT2 Q96NC0 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 CALCOCO1 Homo sapiens Q9P1Z2
Validated Y2H
32296183
Intra
ZMAT2 Q96NC0 CALCOCO1 Homo sapiens Q9P1Z2
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 PRPH Homo sapiens P41219
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 PRPH Homo sapiens P41219
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
ZMAT2 Q96NC0 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
ZMAT2 Q96NC0 AK8 Homo sapiens Q96MA6
Y2H Array
25416956
Intra
ZMAT2 Q96NC0 AK8 Homo sapiens Q96MA6
Y2H Prey Pooling
25416956
Intra
ZMAT2 Q96NC0 NAB2 Homo sapiens Q15742
Y2H Prey Pooling
32296183
Intra
ZMAT2 Q96NC0 NAB2 Homo sapiens Q15742
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Radioulnar Synostosis

  • Radio-Ulnar Synostosis Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16084 ZMAT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26928 Hars2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZMAT2 MGD MGI:1913742
Rattus norvegicus ZMAT2 RGD RGD:1583592
Macaca mulatta ZMAT2 VGNC VGNC:79610
Canis familiaris ZMAT2 VGNC VGNC:48639
Bos taurus ZMAT2 VGNC VGNC:37191
Felis catus ZMAT2 VGNC VGNC:67252
Others ZMAT2 NCBI