FSD2 - fibronectin type III and SPRY domain containing 2 Gene

Also Known as SPRYD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 123722

About FSD2

This gene has 3 transcripts (splice variants), 194 orthologues and 3 paralogues. Biased expression in heart (RPKM 7.7), prostate (RPKM 0.9) and 6 other tissues.

Summary

This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

FSD2 Products (3)

mRNA Protein Name
NM_001007122.4 NP_001007123.1 fibronectin type III and SPRY domain-containing protein 2 isoform a
NM_001281805.2 NP_001268734.1 fibronectin type III and SPRY domain-containing protein 2 isoform b
NM_001281806.2 NP_001268735.1 fibronectin type III and SPRY domain-containing protein 2 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FSD2 Protein Structure

fn3

fn3: Fibronectin type III domain (377 - 460)

SPRY

SPRY: SPRY domain (620 - 732)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
Protein Preferred Names Protein Names

fibronectin type III and SPRY domain-containing protein 2

  • SPRY domain containing 1

FSD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FSD2 A1L4K1 PNMA5 Homo sapiens Q96PV4
Validated Y2H
32296183
Intra
FSD2 A1L4K1 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF572 Homo sapiens Q7Z3I7
MAPPIT
25416956
Intra
FSD2 A1L4K1 ZNF572 Homo sapiens Q7Z3I7
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 ZNF572 Homo sapiens Q7Z3I7
Validated Y2H
25416956
Intra
FSD2 A1L4K1 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra
FSD2 A1L4K1 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
25416956
Intra
FSD2 A1L4K1 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
25416956
Intra
FSD2 A1L4K1 FAM107A Homo sapiens O95990-3
Y2H Array
25416956
Intra
FSD2 A1L4K1 FMR1 Homo sapiens Q06787-8
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 FMR1 Homo sapiens Q06787-8
Validated Y2H
25416956
Intra
FSD2 A1L4K1 FMR1 Homo sapiens Q06787-8
Y2H Array
25416956
Intra
FSD2 A1L4K1 TSGA10IP Homo sapiens Q3SY00
Validated Y2H
32296183
Intra
FSD2 A1L4K1 PBX3 Homo sapiens Q5JS98
Y2H Array
25416956
Intra
FSD2 A1L4K1 ZNF774 Homo sapiens Q6NX45
Validated Y2H
32296183
Intra
FSD2 A1L4K1 LATS1 Homo sapiens Q6PJG3
Validated Y2H
25416956
Intra
FSD2 A1L4K1 LATS1 Homo sapiens Q6PJG3
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 BRD8 Homo sapiens Q9H0E9-2
Validated Y2H
25416956
Intra
FSD2 A1L4K1 BRD8 Homo sapiens Q9H0E9-2
Validated Y2H
32296183
Intra
FSD2 A1L4K1 BRD8 Homo sapiens Q9H0E9-2
Y2H Array
25416956
Intra
FSD2 A1L4K1 SH2D4A Homo sapiens Q9H788-2
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 POLL Homo sapiens Q9UGP5-2
Y2H Array
25416956
Intra
FSD2 A1L4K1 POLL Homo sapiens Q9UGP5-2
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 CORO1A Homo sapiens P31146
Validated Y2H
25416956
Intra
FSD2 A1L4K1 CORO1A Homo sapiens P31146
Validated Y2H
32296183
Intra
FSD2 A1L4K1 EXOC3 Homo sapiens O60645
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ESD Homo sapiens P10768
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ESD Homo sapiens P10768
Anti Tag CoIP
33961781
Intra
FSD2 A1L4K1 ESD Homo sapiens P10768
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 CCDC146 Homo sapiens Q8IYE0
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF35 Homo sapiens P13682
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF230 Homo sapiens Q9UIE0
Y2H Array
25416956
Intra
FSD2 A1L4K1 ZNF230 Homo sapiens Q9UIE0
Validated Y2H
25416956
Intra
FSD2 A1L4K1 ZNF230 Homo sapiens Q9UIE0
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 ZNF490 Homo sapiens Q9ULM2
Validated Y2H
32296183
Intra
FSD2 A1L4K1 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra
FSD2 A1L4K1 CTAG1A Homo sapiens P78358
Validated Y2H
32296183
Intra
FSD2 A1L4K1 HDAC4 Homo sapiens P56524-2
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF837 Homo sapiens Q96EG3
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF777 Homo sapiens Q9ULD5
Validated Y2H
32296183
Intra
FSD2 A1L4K1 VEZF1 Homo sapiens Q14119
Validated Y2H
32296183
Intra
FSD2 A1L4K1 DTNB Homo sapiens O60941-5
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF648 Homo sapiens Q5T619
Validated Y2H
32296183
Intra
FSD2 A1L4K1 SPATC1L Homo sapiens Q9H0A9-2
Validated Y2H
32296183
Intra
FSD2 A1L4K1 MGC50722 Homo sapiens Q8IVT4
Validated Y2H
32296183
Intra
FSD2 A1L4K1 DCX Homo sapiens O43602-2
Validated Y2H
32296183
Intra
FSD2 A1L4K1 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra
FSD2 A1L4K1 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
32296183
Intra
FSD2 A1L4K1 UBTFL1 Homo sapiens P0CB47
Validated Y2H
32296183
Intra
FSD2 A1L4K1 FAM110A Homo sapiens Q9BQ89
Validated Y2H
32296183
Intra
FSD2 A1L4K1 CAMSAP3 Homo sapiens Q9P1Y5-2
Validated Y2H
32296183
Intra
FSD2 A1L4K1 FARS2 Homo sapiens O95363
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF124 Homo sapiens Q15973
Y2H Array
25416956
Intra
FSD2 A1L4K1 ZNF124 Homo sapiens Q15973
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 ZNF124 Homo sapiens Q15973
Validated Y2H
25416956
Intra
FSD2 A1L4K1 PPP1R18 Homo sapiens Q6NYC8
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 PPP1R18 Homo sapiens Q6NYC8
Validated Y2H
25416956
Intra
FSD2 A1L4K1 PPP1R18 Homo sapiens Q6NYC8
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZMAT2 Homo sapiens Q96NC0
Y2H Array
25416956
Intra
FSD2 A1L4K1 ATG14 Homo sapiens Q6ZNE5
Validated Y2H
32296183
Intra
FSD2 A1L4K1 PRPF18 Homo sapiens Q99633
Validated Y2H
32296183
Intra
FSD2 A1L4K1 OXNAD1 Homo sapiens Q96HP4
Validated Y2H
32296183
Intra
FSD2 A1L4K1 SNAPIN Homo sapiens O95295
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF408 Homo sapiens Q9H9D4
Validated Y2H
32296183
Intra
FSD2 A1L4K1 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
FSD2 A1L4K1 SPATC1L Homo sapiens Q9H0A9
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 SPATC1L Homo sapiens Q9H0A9
Y2H Array
25416956
Intra
FSD2 A1L4K1 RNF8 Homo sapiens O76064
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZSCAN26 Homo sapiens Q16670
Y2H Array
25416956
Intra
FSD2 A1L4K1 ZSCAN26 Homo sapiens Q16670
Validated Y2H
25416956
Intra
FSD2 A1L4K1 PPP2R5D Homo sapiens Q14738
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 SMARCE1 Homo sapiens Q969G3
Validated Y2H
32296183
Intra
FSD2 A1L4K1 OIP5 Homo sapiens O43482
Validated Y2H
32296183
Intra
FSD2 A1L4K1 CWF19L2 Homo sapiens Q2TBE0
Validated Y2H
32296183
Intra
FSD2 A1L4K1 MRPL11 Homo sapiens Q9Y3B7
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra
FSD2 A1L4K1 PSMB4 Homo sapiens P28070
Validated Y2H
25416956
Intra
FSD2 A1L4K1 PSMB4 Homo sapiens P28070
Y2H Array
25416956
Intra
FSD2 A1L4K1 PSMB4 Homo sapiens P28070
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 ARFIP2 Homo sapiens P53365
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF587 Homo sapiens Q96SQ5
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF587 Homo sapiens Q96SQ5
Y2H Array
25416956
Intra
FSD2 A1L4K1 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
FSD2 A1L4K1 FAM90A1 Homo sapiens Q86YD7
Y2H Array
25416956
Intra
FSD2 A1L4K1 FAM90A1 Homo sapiens Q86YD7
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 CBX8 Homo sapiens Q9HC52
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 CBX8 Homo sapiens Q9HC52
Validated Y2H
32296183
Intra
FSD2 A1L4K1 CBX8 Homo sapiens Q9HC52
Y2H Array
25416956
Intra
FSD2 A1L4K1 ZNF20 Homo sapiens P17024
Y2H Array
25416956
Intra
FSD2 A1L4K1 TLE5 Homo sapiens Q08117
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
FSD2 A1L4K1 FAM161A Homo sapiens Q3B820
Y2H Array
25416956
Intra
FSD2 A1L4K1 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 FAM161A Homo sapiens Q3B820
Validated Y2H
25416956
Intra
FSD2 A1L4K1 ZNF410 Homo sapiens Q86VK4
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 ZNF76 Homo sapiens P36508
Validated Y2H
32296183
Intra
FSD2 A1L4K1 LENG1 Homo sapiens Q96BZ8
Validated Y2H
32296183
Intra
FSD2 A1L4K1 LENG1 Homo sapiens Q96BZ8
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
FSD2 A1L4K1 HGS Homo sapiens O14964
Validated Y2H
32296183
Intra
FSD2 A1L4K1 KANSL1 Homo sapiens Q7Z3B3
Y2H Array
25416956
Intra
FSD2 A1L4K1 KANSL1 Homo sapiens Q7Z3B3
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 KANSL1 Homo sapiens Q7Z3B3
Validated Y2H
25416956
Intra
FSD2 A1L4K1 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
25416956
Intra
FSD2 A1L4K1 ZNF417 Homo sapiens Q8TAU3
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
FSD2 A1L4K1 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
Intra
FSD2 A1L4K1 THAP7 Homo sapiens Q9BT49
Validated Y2H
32296183
Intra
FSD2 A1L4K1 BEX3 Homo sapiens Q00994
Validated Y2H
32296183
Intra
FSD2 A1L4K1 BEX3 Homo sapiens Q00994
Y2H Array
25416956
Intra
FSD2 A1L4K1 BEX3 Homo sapiens Q00994
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 FAM50B Homo sapiens Q9Y247
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
FSD2 A1L4K1 IFT20 Homo sapiens Q8IY31
Validated Y2H
25416956
Intra
FSD2 A1L4K1 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
FSD2 A1L4K1 CCDC112 Homo sapiens Q8NEF3
Validated Y2H
25416956
Intra
FSD2 A1L4K1 CCDC112 Homo sapiens Q8NEF3
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 AQP1 Homo sapiens P29972
Y2H Array
25416956
Intra
FSD2 A1L4K1 ZNF581 Homo sapiens Q9P0T4
Validated Y2H
32296183
Intra
FSD2 A1L4K1 CDK18 Homo sapiens Q07002
Validated Y2H
32296183
Intra
FSD2 A1L4K1 ZNF580 Homo sapiens Q9UK33
Validated Y2H
32296183
Intra
FSD2 A1L4K1 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
Intra
FSD2 A1L4K1 SH2D4A Homo sapiens Q9H788
Validated Y2H
32296183
Intra
FSD2 A1L4K1 SH2D4A Homo sapiens Q9H788
Y2H Array
25416956
Intra
FSD2 A1L4K1 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra
FSD2 A1L4K1 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
FSD2 A1L4K1 PIK3R3 Homo sapiens Q8N381
Y2H Prey Pooling
25416956
Intra
FSD2 A1L4K1 PIK3R3 Homo sapiens Q8N381
Y2H Array
25416956
Intra
FSD2 A1L4K1 KLHL40 Homo sapiens Q2TBA0
Validated Y2H
32296183
Intra
FSD2 A1L4K1 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Intra
FSD2 A1L4K1 CDC73 Homo sapiens Q6P1J9
Y2H Array
31515488
Intra
FSD2 A1L4K1 TCEANC Homo sapiens Q8N8B7
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05122 FSD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FSD2 VGNC VGNC:40995
Felis catus FSD2 VGNC VGNC:62377
Macaca mulatta FSD2 VGNC VGNC:72738
Bos taurus FSD2 VGNC VGNC:29131
Rattus norvegicus FSD2 RGD RGD:1305167
Mus musculus FSD2 MGD MGI:2444310
Others FSD2 NCBI