ZNF410 - zinc finger protein 410 Gene

Also Known as APA1; APA-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57862

About ZNF410

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,886,859-73,932,521 (from NCBI)

This gene has 23 transcripts (splice variants), 212 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 23.4), bone marrow (RPKM 18.5) and 25 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZNF410 Products (5)

mRNA Protein Name
NM_001242924.2 NP_001229853.1 zinc finger protein 410 isoform a
NM_001242926.2 NP_001229855.1 zinc finger protein 410 isoform c
NM_001242927.2 NP_001229856.1 zinc finger protein 410 isoform d
NM_001242928.2 NP_001229857.1 zinc finger protein 410 isoform e
NM_021188.3 NP_067011.1 zinc finger protein 410 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
33859416 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
33301730 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
enables sequence-specific double-stranded DNA binding IMP
IMP: Inferred from mutant phenotype
33301730 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
33301730 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
33859416 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
33301730 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF410 Protein Structure

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (220 - 243)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (266 - 292)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (295 - 321)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (325 - 349)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 478 a.a.
Protein Preferred Names Protein Names

zinc finger protein 410

  • another partner for ARF 1

ZNF410 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF410 Q86VK4 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra
ZNF410 Q86VK4 ZNF397 Homo sapiens Q8NF99
Y2H Prey Pooling
25416956
Intra
ZNF410 Q86VK4 ZNF397 Homo sapiens Q8NF99
Validated Y2H
25416956
Intra
ZNF410 Q86VK4 ZNF397 Homo sapiens Q8NF99
Y2H Array
25416956
Intra
ZNF410 Q86VK4 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
ZNF410 Q86VK4 FSD2 Homo sapiens A1L4K1
Validated Y2H
25416956
Intra
ZNF410 Q86VK4 FSD2 Homo sapiens A1L4K1
Y2H Array
25416956
Intra
ZNF410 Q86VK4 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra
ZNF410 Q86VK4 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra
ZNF410 Q86VK4 TSGA10 Homo sapiens Q9BZW7
Y2H Prey Pooling
25416956
Intra
ZNF410 Q86VK4 TSGA10 Homo sapiens Q9BZW7
Validated Y2H
25416956
Intra
ZNF410 Q86VK4 RAB3IP Homo sapiens Q96QF0
Validated Y2H
25416956
Intra
ZNF410 Q86VK4 RAB3IP Homo sapiens Q96QF0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure 11

  • SPGF11
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16138 ZNF410 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ZNF410 VGNC VGNC:80788
Bos taurus ZNF410 VGNC VGNC:37271
Macaca mulatta ZNF410 VGNC VGNC:99352
Rattus norvegicus ZNF410 RGD RGD:1305636
Canis familiaris ZNF410 VGNC VGNC:48722
Mus musculus ZNF410 MGD MGI:1289280
Others ZNF410 NCBI