ZNF397 - zinc finger protein 397 Gene

Also Known as ZNF47; ZSCAN15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84307

Summary

This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
Ubiquitous expression in thyroid (RPKM 5.5), brain (RPKM 5.3) and 25 other tissues.

ZNF397 Products (1)

mRNA Protein Name
NG_015815.1 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20211142 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
12801647 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
12801647 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12801647 GOA
NOT involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12801647 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12801647 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12801647 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF397 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF397 Q8NF99 PRKAA2 Homo sapiens P54646
Y2H Array
25416956
Intra
ZNF397 Q8NF99 LMO4 Homo sapiens P61968
Validated Y2H
25416956
Intra
ZNF397 Q8NF99 LMO4 Homo sapiens P61968
Y2H Array
25416956
Intra
ZNF397 Q8NF99 ZNF446 Homo sapiens Q9NWS9
Anti Tag CoIP
33961781
Intra
ZNF397 Q8NF99 ZNF446 Homo sapiens Q9NWS9
Anti Tag CoIP
28514442
Intra
ZNF397 Q8NF99 ZNF446 Homo sapiens Q9NWS9-2
Y2H Array
25416956
Intra
ZNF397 Q8NF99 ZNF446 Homo sapiens Q9NWS9-2
Y2H Prey Pooling
25416956
Intra
ZNF397 Q8NF99 SCAND1 Homo sapiens P57086
Anti Tag CoIP
33961781
Intra
ZNF397 Q8NF99 SCAND1 Homo sapiens P57086
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction