CORO1A - coronin 1A Gene

Also Known as p57; IMD8; TACO; CLABP; HCORO1; CLIPINA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11151

About CORO1A

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,183,602-30,189,076 (from NCBI)

This gene has 18 transcripts (splice variants), 186 orthologues, 6 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 216.7), bone marrow (RPKM 179.6) and 10 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

CORO1A Products (2)

mRNA	Protein	Name
NM_001193333.3	NP_001180262.1	coronin-1A
NM_007074.4	NP_009005.1	coronin-1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IPI IPI: Inferred from physical interaction	23100250	GOA
enables actin filament binding	IDA IDA: Inferred from direct assay	7758584	GOA
enables actin filament binding	IMP IMP: Inferred from mutant phenotype	22364218	GOA
enables actin monomer binding	IMP IMP: Inferred from mutant phenotype	23100250	GOA
enables myosin heavy chain binding	IPI IPI: Inferred from physical interaction	23100250	GOA
enables phosphatidylinositol 3-kinase binding	IDA IDA: Inferred from direct assay	11094157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9365277	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15601263	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17442961	GOA
involved in cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	17442961	GOA
NOT involved in immunological synapse formation	IMP IMP: Inferred from mutant phenotype	24760828	GOA
involved in natural killer cell degranulation	IMP IMP: Inferred from mutant phenotype	24760828	GOA
involved in negative regulation of actin nucleation	IDA IDA: Inferred from direct assay	17442961	GOA
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	17442961	GOA
involved in phagolysosome assembly	IMP IMP: Inferred from mutant phenotype	12132654	GOA
involved in positive chemotaxis	IDA IDA: Inferred from direct assay	17442961	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24760828	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin filament	IDA IDA: Inferred from direct assay	15800061	GOA
colocalizes with cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	24760828	GOA
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	15800061	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17341475	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	24760828	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	17442961	GOA
NOT located in nucleus	IDA IDA: Inferred from direct assay	17341475	GOA
located in phagocytic cup	IDA IDA: Inferred from direct assay	17442961	GOA
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	17442961	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17341475	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11094157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CORO1A Protein Structure

DUF1899

WD40

Trimer_CC

0
100
200
300
400
461 a.a.

Protein Preferred Names	Protein Names
coronin-1A	clipin-A

CORO1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CORO1A	P31146	STAT3	Homo sapiens	P40763	Y2H	21988832
Intra	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	32296183
Intra	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Array	25416956
Intra	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Array	32296183
Intra	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Array	31515488
Intra	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	25416956
Intra	CORO1A	P31146	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	CORO1A	P31146	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	CORO1A	P31146	MAGEA11	Homo sapiens	P43364	Validated Y2H	32296183
Intra	CORO1A	P31146	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	CORO1A	P31146	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	CORO1A	P31146	IFT20	Homo sapiens	Q8IY31-3	Y2H Prey Pooling	32296183
Intra	CORO1A	P31146	IFT20	Homo sapiens	Q8IY31-3	Validated Y2H	32296183
Intra	CORO1A	P31146	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 8	Severe Combined Immunodeficiency Due To Coro1a Deficiency IMD8 Scid Due To Coro1a Deficiency Scid Due To Coronin-1a Deficiency Severe Combined Immunodeficiency Due To Coronin-1a Deficiency Immunodeficiency, Type 8
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Coronin-1a Deficiency
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Molluscum Contagiosum	Water Warts Molluscum Verrucosum
Immunodeficiency 19	IMD19 Cd3-Delta Deficiency Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive Cd3delta Deficiency Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive Immunodeficiency 19, Severe Combined Cd3d Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency Immunodeficiency, Type 19
Immunodeficiency 40	Dock2 Deficiency IMD40 Immunodeficiency, Type 40
Lymphopenia	Lymphocytopenia
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Immunodeficiency 7	Tcr-Alpha-Beta-Positive T-Cell Deficiency IMD7 T-Cell Receptor-Alpha/Beta Deficiency Immunodeficiency 7, Tcr-Alpha/Beta Deficient Tcr-Alpha/Beta Deficiency Tcr-Alpha-Beta+ T-Cell Deficiency T-Cell Receptor Alpha/Beta Deficiency
Immunodeficiency 9	Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 1 Combined Immunodeficiency Due To Orai1 Deficiency IMD9 Cid Due To Orai1 Deficiency Severe Combined Immunodeficiency Due To Crac Channel Dysfunction Immunodeficiency, Type 9
Immunodeficiency 20	Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Natural Killer Cell Cytotoxicity IMD20 Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Nk Cell Cytotoxicity Cd16 Deficiency Immunodeficiency, Type 20
Epidermodysplasia Verruciformis 1	Epidermodysplasia Verruciformis Epidermodysplasia Verruciformis, Susceptibility To, 1 Lutz-Lewandowsky Epidermodysplasia Verruciformis EV1 Lewandowsky-Lutz Syndrome Ev
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	XMEN X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia Cid Due To Magt1 Deficiency Combined Immunodeficiency Due To Magt1 Deficiency X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia
Lymphoproliferative Syndrome 2	Cd27 Deficiency LPFS2 Combined Immunodeficiency Due To Cd27 Deficiency Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency
Superficial Mycosis	Piedra Steroid-Modified Tinea Infection
Pityriasis Versicolor	Tinea Versicolor Infection By Pityrosporum Furfur
T Cell Deficiency	T Cell Immunodeficiency T Lymphocyte Deficiency T Lymphocyte Immunodeficiency T-Lymphocyte Deficiency
Omenn Syndrome	Histiocytic Medullary Reticulosis Severe Combined Immunodeficiency With Hypereosinophilia Combined Immunodeficiency With Hypereosinophilia Reticuloendotheliosis, Familial, With Eosinophilia Reticuloendotheliosis Familial With Eosinophilia Familial Reticuloendotheliosis Omenn'S Syndrome OS Malignant Histiocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03048	CORO1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21841	Coro1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28357	Coro1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CORO1A	VGNC	VGNC:61101
Mus musculus	CORO1A	MGD	MGI:1345961
Macaca mulatta	CORO1A	VGNC	VGNC:71319
Bos taurus	CORO1A	VGNC	VGNC:27620
Canis familiaris	CORO1A	VGNC	VGNC:39527
Rattus norvegicus	CORO1A	RGD	RGD:620009
Others	CORO1A	NCBI