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BEX3 - brain expressed X-linked 3 Gene

Also Known as Bex; NADE; HGR74; NGFRAP1; DXS6984E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27018

About BEX3

Cytogenetic location: Xq22.2 Genomic coordinates (GRCh38): X:103,376,323-103,378,164 (from NCBI)

This gene has 4 transcripts (splice variants), 90 orthologues and 3 paralogues. Broad expression in brain (RPKM 147.0), ovary (RPKM 108.9) and 24 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

BEX3 Products (4)

mRNA	Protein	Name
NM_001282674.1	NP_001269603.1	protein BEX3 isoform c
NM_014380.3	NP_055195.1	protein BEX3 isoform b
NM_206915.3	NP_996798.1	protein BEX3 isoform b
NM_206917.3	NP_996800.1	protein BEX3 isoform a

BEX3 Protein Structure

BEX

0
100
111 a.a.

Protein Preferred Names	Protein Names
protein BEX3	brain-expressed X-linked protein 3

BEX3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	BEX3	Q00994	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	25416956
Intra	BEX3	Q00994	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	32296183
Intra	BEX3	Q00994	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	BEX3	Q00994	GOLGA8F	Homo sapiens	Q08AF8	Validated Y2H	25416956
Intra	BEX3	Q00994	GOLGA8F	Homo sapiens	Q08AF8	Y2H Array	25416956
Intra	BEX3	Q00994	GOLGA8DP	Homo sapiens	Q0D2H9	Y2H Array	25416956
Intra	BEX3	Q00994	BFSP2	Homo sapiens	Q13515	Validated Y2H	32296183
Intra	BEX3	Q00994	TSC1	Homo sapiens	Q92574	Y2H	17355907
Intra	BEX3	Q00994	TSC1	Homo sapiens	Q92574	Confocal	17355907
Intra	BEX3	Q00994	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	BEX3	Q00994	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	BEX3	Q00994	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	BEX3	Q00994	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	BEX3	Q00994	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	BEX3	Q00994	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	CBY2	Homo sapiens	Q8NA61-2	Validated Y2H	32296183
Intra	BEX3	Q00994	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	EMILIN1	Homo sapiens	Q9Y6C2-2	Validated Y2H	32296183
Intra	BEX3	Q00994	EMILIN1	Homo sapiens	Q9Y6C2-2	Y2H Array	32296183
Intra	BEX3	Q00994	MCCD1	Homo sapiens	P59942	Y2H Array	32296183
Intra	BEX3	Q00994	MCCD1	Homo sapiens	P59942	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	S100Z	Homo sapiens	Q8WXG8	Validated Y2H	32296183
Intra	BEX3	Q00994	S100Z	Homo sapiens	Q8WXG8	Y2H Array	32296183
Intra	BEX3	Q00994	S100Z	Homo sapiens	Q8WXG8	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	BEX3	Q00994	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	BEX3	Q00994	TSNAX	Homo sapiens	Q99598	Y2H Array	32296183
Intra	BEX3	Q00994	TSNAX	Homo sapiens	Q99598	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	TSNAX	Homo sapiens	Q99598	Validated Y2H	32296183
Intra	BEX3	Q00994	TACC3	Homo sapiens	Q9Y6A5	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	TACC3	Homo sapiens	Q9Y6A5	Validated Y2H	32296183
Intra	BEX3	Q00994	TACC3	Homo sapiens	Q9Y6A5	Y2H Array	32296183
Intra	BEX3	Q00994	ING4	Homo sapiens	Q9UNL4	Validated Y2H	32296183
Intra	BEX3	Q00994	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	BEX3	Q00994	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	BEX3	Q00994	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	BEX3	Q00994	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	BEX3	Q00994	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	BEX3	Q00994	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	BEX3	Q00994	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	BEX3	Q00994	ING5	Homo sapiens	Q8WYH8	Validated Y2H	32296183
Intra	BEX3	Q00994	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	BEX3	Q00994	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	BEX3	Q00994	FSD2	Homo sapiens	A1L4K1	Validated Y2H	25416956
Intra	BEX3	Q00994	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	FSD2	Homo sapiens	A1L4K1	Y2H Array	32296183
Intra	BEX3	Q00994	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	BEX3	Q00994	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	BEX3	Q00994	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	25416956
Intra	BEX3	Q00994	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	25416956
Intra	BEX3	Q00994	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	BEX3	Q00994	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	BEX3	Q00994	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	BEX3	Q00994	BEX3	Homo sapiens	Q00994	Y2H Array	25416956
Intra	BEX3	Q00994	BEX3	Homo sapiens	Q00994	Y2H Array	32296183
Intra	BEX3	Q00994	CCDC116	Homo sapiens	Q8IYX3	Validated Y2H	25416956
Intra	BEX3	Q00994	BEX3	Homo sapiens	Q00994	Validated Y2H	32296183
Intra	BEX3	Q00994	BEX3	Homo sapiens	Q00994	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	S100A1	Homo sapiens	P23297	Y2H Array	32296183
Intra	BEX3	Q00994	S100A1	Homo sapiens	P23297	Y2H Prey Pooling	32296183
Intra	BEX3	Q00994	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	BEX3	Q00994	EMILIN1	Homo sapiens	Q9Y6C2	Y2H Prey Pooling	25416956
Intra	BEX3	Q00994	EMILIN1	Homo sapiens	Q9Y6C2	Validated Y2H	25416956
Intra	BEX3	Q00994	CTNNBL1	Homo sapiens	Q8WYA6	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cogan-Reese Syndrome
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS01482	BEX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	BEX3	VGNC	VGNC:54665
Bos taurus	BEX3	VGNC	VGNC:50552
Rattus norvegicus	BEX3	RGD	RGD:3148
Mus musculus	BEX3	MGD	MGI:1338016
Others	BEX3	NCBI