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CTNNBL1 - catenin beta like 1 Gene

Also Known as NAP; P14L; IMD99; PP8304; C20orf33; dJ633O20.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56259

About CTNNBL1

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:37,694,030-37,872,118 (from NCBI)

This gene has 10 transcripts (splice variants), 214 orthologues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 24.9), testis (RPKM 22.5) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

CTNNBL1 Products (2)

mRNA	Protein	Name
NM_001281495.2	NP_001268424.1	beta-catenin-like protein 1 isoform 2
NM_030877.5	NP_110517.2	beta-catenin-like protein 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	18722174	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18722174	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	12659813	GOA
involved in somatic diversification of immunoglobulins	IMP IMP: Inferred from mutant phenotype	18722174	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Prp19 complex	IDA IDA: Inferred from direct assay	15175653	GOA
part of Prp19 complex	IPI IPI: Inferred from physical interaction	20176811	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12659813	GOA
part of spliceosomal complex	IDA IDA: Inferred from direct assay	20176811	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	20176811	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTNNBL1 Protein Structure

CTNNBL

0
100
200
300
400
500
563 a.a.

Protein Preferred Names	Protein Names
beta-catenin-like protein 1	nuclear associated protein

CTNNBL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CTNNBL1	Q8WYA6	CATIP	Homo sapiens	Q7Z7H3	Validated Y2H	25416956
Intra	CTNNBL1	Q8WYA6	CATIP	Homo sapiens	Q7Z7H3	Y2H Array	25416956
Intra	CTNNBL1	Q8WYA6	CWC15	Homo sapiens	Q9P013	Anti Tag CoIP	35271311
Intra	CTNNBL1	Q8WYA6	CWC15	Homo sapiens	Q9P013	Density Sedimentation	20176811
Intra	CTNNBL1	Q8WYA6	CWC15	Homo sapiens	Q9P013	Crosslink	20176811
Intra	CTNNBL1	Q8WYA6	PRDM4	Homo sapiens	Q9UKN5	Validated Y2H	25416956
Intra	CTNNBL1	Q8WYA6	PRDM4	Homo sapiens	Q9UKN5	Y2H Array	25416956
Intra	CTNNBL1	Q8WYA6	CDC5L	Homo sapiens	Q99459	ITC	24269683
Intra	CTNNBL1	Q8WYA6	CDC5L	Homo sapiens	Q99459	Anti Tag CoIP	35271311
Intra	CTNNBL1	Q8WYA6	CDC5L	Homo sapiens	Q99459	Pull Down	24269683
Intra	CTNNBL1	Q8WYA6	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	25416956
Intra	CTNNBL1	Q8WYA6	MED4	Homo sapiens	Q9NPJ6	Validated Y2H	25416956
Intra	CTNNBL1	Q8WYA6	MED4	Homo sapiens	Q9NPJ6	Y2H Array	25416956
Intra	CTNNBL1	Q8WYA6	CDCA7L	Homo sapiens	Q96GN5	Y2H Array	29892012
Intra	CTNNBL1	Q8WYA6	SNW1	Homo sapiens	Q13573	Y2H	22365833
Intra	CTNNBL1	Q8WYA6	CREBZF	Homo sapiens	Q9NS37	Validated Y2H	25416956
Intra	CTNNBL1	Q8WYA6	CREBZF	Homo sapiens	Q9NS37	Y2H Array	25416956
Intra	CTNNBL1	Q8WYA6	LDOC1	Homo sapiens	O95751	Y2H Array	31515488
Intra	CTNNBL1	Q8WYA6	LDOC1	Homo sapiens	O95751	Y2H Array	25416956
Intra	CTNNBL1	Q8WYA6	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	25416956
Intra	CTNNBL1	Q8WYA6	BEX3	Homo sapiens	Q00994	Y2H Prey Pooling	25416956
Intra	CTNNBL1	Q8WYA6	BEX3	Homo sapiens	Q00994	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

CTNNBL1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84695	CTNNBL1 Antibody (YA4392)	WB, IHC-P, ICC/IF, FC, ELISA	Human
HY-P84695A	CTNNBL1 Antibody (YA4392)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Immunodeficiency 99 With Hypogammaglobulinemia And Autoimmune Cytopenias	IMD99

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03310	CTNNBL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CTNNBL1	VGNC	VGNC:71414
Canis familiaris	CTNNBL1	VGNC	VGNC:39701
Rattus norvegicus	CTNNBL1	RGD	RGD:1563558
Bos taurus	CTNNBL1	VGNC	VGNC:27804
Mus musculus	CTNNBL1	MGD	MGI:1913892
Felis catus	CTNNBL1	VGNC	VGNC:61257
Others	CTNNBL1	NCBI