CTNNBL1 Antibody (YA4392)
(Synonyms: NAP; P14L; PP8304; C20orf33; dJ633O20.1)CTNNBL1 Antibody (YA4392) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CTNNBL1.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:50-1:200 | 1:200-1:400 | 1:10000 |
Product Details
CTNNBL1 Antibody (YA4392) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CTNNBL1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 65 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 65 kDa
Purified recombinant fragment of human CTNNBL1 (AA: 390-557) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CTNNBL1 component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated somatic hypermutation (SHM) and class-switch recombination (CSR), 2 processes resulting in the production of high-affinity, mutated isotype-switched antibodies[1].
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_specificity:Widely expressed with highest levels in skeletal muscle, placenta, heart, spleen, testis and thyroid -
Isoforms & Post-Translational Modification
Q8WYA6 has 4 isomers: Q8WYA6-1: 65173 Da (predicted); Q8WYA6-2: 43392 Da (predicted); Q8WYA6-3: 36103 Da (predicted); Q8WYA6-4: 61971 Da (predicted).
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Subunit
Component of the PRP19-CDC5L splicing complex composed of a core complex comprising a homotetramer of PRPF19, CDC5L, PLRG1 and BCAS2, and at least three less stably associated proteins CTNNBL1, CWC15 and HSPA8. Interacts directly with CWC15 and CDC5L in the complex (PubMed:32484799). Interacts with AICDA; the interaction is important for the antibody diversification activity of AICDA (PubMed:18722174, PubMed:21385873). Interacts with PRPF31 (via its NLS). Interacts (via its N-terminal NLS) with KPNA1 and KPNA2
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SwissProt ID
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Synonyms
NAP; P14L; PP8304; C20orf33; dJ633O20.1
Documentation
References
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