LDOC1 - LDOC1 regulator of NFKB signaling Gene

Also Known as Mar7; RTL7; BCUR1; Mart7; SIRH7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23641

About LDOC1

Cytogenetic location: Xq27.1 Genomic coordinates (GRCh38): X:141,173,235-141,177,129 (from NCBI)

This gene has 3 transcripts (splice variants), 77 orthologues and 10 paralogues.

Summary

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some Cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. [provided by RefSeq, Jul 2008]

LDOC1 Products (1)

mRNA	Protein	Name
NM_012317.4	NP_036449.1	protein LDOC1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	27812135	GOA
involved in cellular response to muramyl dipeptide	IMP IMP: Inferred from mutant phenotype	27812135	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein LDOC1	Sushi-Ichi retrotransposon homolog 7

LDOC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LDOC1	O95751	TASOR2	Homo sapiens	Q5VWN6-2	Validated Y2H	25416956
Intra	LDOC1	O95751	TASOR2	Homo sapiens	Q5VWN6-2	Y2H Array	25416956
Intra	LDOC1	O95751	ZNF250	Homo sapiens	P15622-3	Validated Y2H	32296183
Intra	LDOC1	O95751	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	ZGPAT	Homo sapiens	Q8N5A5-2	Y2H Array	25416956
Intra	LDOC1	O95751	TSGA10IP	Homo sapiens	Q3SY00	Validated Y2H	32296183
Intra	LDOC1	O95751	RAB7L1	Homo sapiens	Q6FGU7	Validated Y2H	25416956
Intra	LDOC1	O95751	RAB7L1	Homo sapiens	Q6FGU7	Y2H Array	25416956
Intra	LDOC1	O95751	ZNF774	Homo sapiens	Q6NX45	Y2H Array	25416956
Intra	LDOC1	O95751	ZNF774	Homo sapiens	Q6NX45	Y2H Array	31515488
Intra	LDOC1	O95751	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	LATS1	Homo sapiens	Q6PJG3	Y2H Array	25416956
Intra	LDOC1	O95751	AEBP2	Homo sapiens	Q6ZN18-2	Validated Y2H	32296183
Intra	LDOC1	O95751	ZNF564	Homo sapiens	Q8TBZ8	Validated Y2H	25416956
Intra	LDOC1	O95751	ZNF564	Homo sapiens	Q8TBZ8	Y2H Array	25416956
Intra	LDOC1	O95751	MFAP1	Homo sapiens	P55081	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	MFAP1	Homo sapiens	P55081	Validated Y2H	25416956
Intra	LDOC1	O95751	MFAP1	Homo sapiens	P55081	Validated Y2H	32296183
Intra	LDOC1	O95751	MFAP1	Homo sapiens	P55081	Y2H Array	25416956
Intra	LDOC1	O95751	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	LDOC1	O95751	IQCB1	Homo sapiens	Q15051-2	Validated Y2H	32296183
Intra	LDOC1	O95751	HDAC4	Homo sapiens	P56524-2	Validated Y2H	32296183
Intra	LDOC1	O95751	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	LDOC1	O95751	LMO2	Homo sapiens	P25791-3	Validated Y2H	32296183
Intra	LDOC1	O95751	MBD3	Homo sapiens	O95983-2	Validated Y2H	32296183
Intra	LDOC1	O95751	ZNF648	Homo sapiens	Q5T619	Validated Y2H	32296183
Intra	LDOC1	O95751	WDR25	Homo sapiens	Q64LD2-2	Validated Y2H	32296183
Intra	LDOC1	O95751	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	32296183
Intra	LDOC1	O95751	PRPF31	Homo sapiens	Q8WWY3	Y2H Array	25416956
Intra	LDOC1	O95751	PRPF31	Homo sapiens	Q8WWY3	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	UBTFL1	Homo sapiens	P0CB47	Validated Y2H	32296183
Intra	LDOC1	O95751	HOXC8	Homo sapiens	P31273	Validated Y2H	32296183
Intra	LDOC1	O95751	FAM110A	Homo sapiens	Q9BQ89	Validated Y2H	32296183
Intra	LDOC1	O95751	TSNAX	Homo sapiens	Q99598	Validated Y2H	32296183
Intra	LDOC1	O95751	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	ZFP1	Homo sapiens	Q6P2D0	Validated Y2H	32296183
Intra	LDOC1	O95751	ZNF124	Homo sapiens	Q15973	Validated Y2H	32296183
Intra	LDOC1	O95751	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	32296183
Intra	LDOC1	O95751	PRPF18	Homo sapiens	Q99633	Validated Y2H	32296183
Intra	LDOC1	O95751	PEG10	Homo sapiens	Q86TG7	Validated Y2H	25416956
Intra	LDOC1	O95751	PEG10	Homo sapiens	Q86TG7	Y2H Array	25416956
Intra	LDOC1	O95751	PEG10	Homo sapiens	Q86TG7	Anti Tag CoIP	33961781
Intra	LDOC1	O95751	HDAC4	Homo sapiens	P56524	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	HDAC4	Homo sapiens	P56524	Validated Y2H	25416956
Intra	LDOC1	O95751	HDAC4	Homo sapiens	P56524	Y2H Array	25416956
Intra	LDOC1	O95751	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	25416956
Intra	LDOC1	O95751	TBC1D7	Homo sapiens	Q9P0N9	Validated Y2H	32296183
Intra	LDOC1	O95751	TBC1D7	Homo sapiens	Q9P0N9	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	ZGPAT	Homo sapiens	Q8N5A5	Y2H Array	31515488
Intra	LDOC1	O95751	ZGPAT	Homo sapiens	Q8N5A5	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	ZGPAT	Homo sapiens	Q8N5A5	Validated Y2H	25416956
Intra	LDOC1	O95751	ZGPAT	Homo sapiens	Q8N5A5	Y2H Array	25416956
Intra	LDOC1	O95751	ZNF408	Homo sapiens	Q9H9D4	Y2H Pooling	16189514
Intra	LDOC1	O95751	ZNF408	Homo sapiens	Q9H9D4	Y2H Array	19060904
Intra	LDOC1	O95751	ZNF408	Homo sapiens	Q9H9D4	Y2H Pooling	19060904
Intra	LDOC1	O95751	BYSL	Homo sapiens	Q13895	Validated Y2H	32296183
Intra	LDOC1	O95751	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	LDOC1	O95751	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	LDOC1	O95751	PSMA1	Homo sapiens	P25786	Validated Y2H	32296183
Intra	LDOC1	O95751	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	LDOC1	O95751	DPF2	Homo sapiens	Q92785	Validated Y2H	32296183
Intra	LDOC1	O95751	DPF2	Homo sapiens	Q92785	Y2H Array	25416956
Intra	LDOC1	O95751	DPF2	Homo sapiens	Q92785	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	RPP25	Homo sapiens	Q9BUL9	Validated Y2H	32296183
Intra	LDOC1	O95751	GADD45GIP1	Homo sapiens	Q8TAE8	Validated Y2H	32296183
Intra	LDOC1	O95751	CDC5L	Homo sapiens	Q99459	Validated Y2H	32296183
Intra	LDOC1	O95751	HOXB5	Homo sapiens	P09067	Validated Y2H	32296183
Intra	LDOC1	O95751	NXF1	Homo sapiens	Q9UBU9	Y2H Array	25416956
Intra	LDOC1	O95751	NXF1	Homo sapiens	Q9UBU9	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	MEAF6	Homo sapiens	Q9HAF1	Y2H Array	25416956
Intra	LDOC1	O95751	MEAF6	Homo sapiens	Q9HAF1	Validated Y2H	25416956
Intra	LDOC1	O95751	BARD1	Homo sapiens	Q99728	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	BARD1	Homo sapiens	Q99728	Validated Y2H	32296183
Intra	LDOC1	O95751	BARD1	Homo sapiens	Q99728	Y2H Array	25416956
Intra	LDOC1	O95751	UTP14A	Homo sapiens	Q9BVJ6	Y2H Array	31515488
Intra	LDOC1	O95751	ABLIM1	Homo sapiens	O14639	Y2H Pooling	16189514
Intra	LDOC1	O95751	ATF4	Homo sapiens	P18848	Y2H Array	31515488
Intra	LDOC1	O95751	ATF4	Homo sapiens	P18848	Validated Y2H	25416956
Intra	LDOC1	O95751	ATF4	Homo sapiens	P18848	Y2H Array	29892012
Intra	LDOC1	O95751	SUDS3	Homo sapiens	Q9H7L9	Validated Y2H	32296183
Intra	LDOC1	O95751	AP1M1	Homo sapiens	Q9BXS5	Y2H Array	19060904
Intra	LDOC1	O95751	AP1M1	Homo sapiens	Q9BXS5	Y2H Pooling	19060904
Intra	LDOC1	O95751	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	LDOC1	O95751	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
Intra	LDOC1	O95751	PEG10	Homo sapiens	Q86TG7-2	Validated Y2H	32296183
Intra	LDOC1	O95751	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	LDOC1	O95751	TTC23	Homo sapiens	Q5W5X9	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	TTC23	Homo sapiens	Q5W5X9	Y2H Array	25416956
Intra	LDOC1	O95751	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	25416956
Intra	LDOC1	O95751	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	LDOC1	O95751	DPPA4	Homo sapiens	Q7L190	Validated Y2H	25416956
Intra	LDOC1	O95751	DPPA4	Homo sapiens	Q7L190	Y2H Pooling	16189514
Intra	LDOC1	O95751	DPPA4	Homo sapiens	Q7L190	Validated Y2H	32296183
Intra	LDOC1	O95751	ATP6V1G1	Homo sapiens	O75348	Y2H Array	25416956
Intra	LDOC1	O95751	ATP6V1G1	Homo sapiens	O75348	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	ZBTB16	Homo sapiens	Q05516	Validated Y2H	32296183
Intra	LDOC1	O95751	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	LDOC1	O95751	FAM161A	Homo sapiens	Q3B820	Validated Y2H	32296183
Intra	LDOC1	O95751	LENG1	Homo sapiens	Q96BZ8	Y2H Array	31515488
Intra	LDOC1	O95751	LENG1	Homo sapiens	Q96BZ8	Validated Y2H	32296183
Intra	LDOC1	O95751	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	LDOC1	O95751	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	LDOC1	O95751	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	HGS	Homo sapiens	O14964	Y2H Array	25416956
Intra	LDOC1	O95751	HGS	Homo sapiens	O14964	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	HGS	Homo sapiens	O14964	Validated Y2H	25416956
Intra	LDOC1	O95751	FXR2	Homo sapiens	P51116	Y2H Pooling	19060904
Intra	LDOC1	O95751	FXR2	Homo sapiens	P51116	Y2H Array	19060904
Intra	LDOC1	O95751	THAP7	Homo sapiens	Q9BT49	Validated Y2H	32296183
Intra	LDOC1	O95751	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	LDOC1	O95751	CFAP53	Homo sapiens	Q96M91	Validated Y2H	32296183
Intra	LDOC1	O95751	FAM50B	Homo sapiens	Q9Y247	Y2H Pooling	19060904
Intra	LDOC1	O95751	FAM50B	Homo sapiens	Q9Y247	Validated Y2H	32296183
Intra	LDOC1	O95751	FAM50B	Homo sapiens	Q9Y247	Y2H Array	19060904
Intra	LDOC1	O95751	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	LDOC1	O95751	ZBTB24	Homo sapiens	O43167	Y2H Array	25416956
Intra	LDOC1	O95751	ZBTB24	Homo sapiens	O43167	Y2H Array	32296183
Intra	LDOC1	O95751	BEX2	Homo sapiens	Q9BXY8	Validated Y2H	32296183
Intra	LDOC1	O95751	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	LDOC1	O95751	GNL3L	Homo sapiens	Q9NVN8	Y2H Pooling	16189514
Intra	LDOC1	O95751	GNL3L	Homo sapiens	Q9NVN8	Validated Y2H	32296183
Intra	LDOC1	O95751	SH2D4A	Homo sapiens	Q9H788	Y2H Array	25416956
Intra	LDOC1	O95751	SH2D4A	Homo sapiens	Q9H788	Y2H Array	31515488
Intra	LDOC1	O95751	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	25416956
Intra	LDOC1	O95751	SH2D4A	Homo sapiens	Q9H788	Validated Y2H	32296183
Intra	LDOC1	O95751	TEAD4	Homo sapiens	Q15561	Validated Y2H	32296183
Intra	LDOC1	O95751	CTNNBL1	Homo sapiens	Q8WYA6	Validated Y2H	25416956
Intra	LDOC1	O95751	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	32296183
Intra	LDOC1	O95751	RALBP1	Homo sapiens	Q15311	Validated Y2H	32296183
Intra	LDOC1	O95751	GPANK1	Homo sapiens	O95872	Validated Y2H	32296183
Intra	LDOC1	O95751	TTC23	Homo sapiens	Q5W5X9-3	Validated Y2H	32296183
Intra	LDOC1	O95751	ZNF629	Homo sapiens	Q9UEG4	Validated Y2H	32296183
Intra	LDOC1	O95751	BARD1	Homo sapiens	A0AVN2	Y2H Prey Pooling	25416956
Intra	LDOC1	O95751	BARD1	Homo sapiens	A0AVN2	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Familial Febrile Seizures	Familial Febrile Convulsions Feb Febrile Seizures, Familial
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07581	LDOC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LDOC1	MGD	MGI:2685212
Canis familiaris	LDOC1	VGNC	VGNC:42627
Rattus norvegicus	LDOC1	RGD	RGD:1565644
Macaca mulatta	LDOC1	VGNC	VGNC:74249
Felis catus	LDOC1	VGNC	VGNC:68032
Others	LDOC1	NCBI