HOXB5 - homeobox B5 Gene

Also Known as HOX2; HU-1; HOX2A; Hox2.1; HHO.C10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3215

About HOXB5

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,591,257-48,593,779 (from NCBI)

This gene has 1 transcript (splice variant), 258 orthologues and 42 paralogues. Biased expression in kidney (RPKM 6.1), colon (RPKM 5.0) and 13 other tissues.

Summary

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue. [provided by RefSeq, Jul 2008]

HOXB5 Products (1)

mRNA Protein Name
NM_002147.4 NP_002138.1 homeobox protein Hox-B5
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXB5 Protein Structure

Homeobox

Homeobox: Homeobox domain (195 - 251)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-B5

  • homeo box 2A

HOXB5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HOXB5 P09067 KRTAP10-8 Homo sapiens P60410 32296183
Intra
HOXB5 P09067 KRTAP10-8 Homo sapiens P60410 32296183
Intra
HOXB5 P09067 KRTAP10-8 Homo sapiens P60410 32296183
Intra
HOXB5 P09067 CTBP1 Homo sapiens Q13363-2 25416956
Intra
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 32296183
Intra
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 25416956
Intra
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 25416956
Intra
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 32296183
Intra
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 32296183
Intra
HOXB5 P09067 CTBP2 Homo sapiens P56545-3 25416956
Intra
HOXB5 P09067 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
HOXB5 P09067 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
HOXB5 P09067 MID2 Homo sapiens Q9UJV3-2 32296183
Intra
HOXB5 P09067 MAGEA11 Homo sapiens P43364-2 25416956
Intra
HOXB5 P09067 CADPS Homo sapiens A2RRN7 32296183
Intra
HOXB5 P09067 CADPS Homo sapiens A2RRN7 32296183
Intra
HOXB5 P09067 ZNF774 Homo sapiens Q6NX45 32296183
Intra
HOXB5 P09067 ZNF774 Homo sapiens Q6NX45 32296183
Intra
HOXB5 P09067 ZNF774 Homo sapiens Q6NX45 32296183
Intra
HOXB5 P09067 NFKBID Homo sapiens Q8NI38 32296183
Intra
HOXB5 P09067 NFKBID Homo sapiens Q8NI38 32296183
Intra
HOXB5 P09067 NFKBID Homo sapiens Q8NI38 32296183
Intra
HOXB5 P09067 PBX4 Homo sapiens Q9BYU1 32296183
Intra
HOXB5 P09067 PBX4 Homo sapiens Q9BYU1 32296183
Intra
HOXB5 P09067 PBX4 Homo sapiens Q9BYU1 32296183
Intra
HOXB5 P09067 KRT34 Homo sapiens O76011 32296183
Intra
HOXB5 P09067 KRT34 Homo sapiens O76011 32296183
Intra
HOXB5 P09067 ZNF286A Homo sapiens Q9HBT8 32296183
Intra
HOXB5 P09067 ZNF286A Homo sapiens Q9HBT8 32296183
Intra
HOXB5 P09067 ZNF286A Homo sapiens Q9HBT8 32296183
Intra
HOXB5 P09067 HOOK2 Homo sapiens Q96ED9-2 32296183
Intra
HOXB5 P09067 HOOK2 Homo sapiens Q96ED9-2 32296183
Intra
HOXB5 P09067 HOOK2 Homo sapiens Q96ED9-2 32296183
Intra
HOXB5 P09067 GOLGA6A Homo sapiens Q9NYA3 32296183
Intra
HOXB5 P09067 GOLGA6A Homo sapiens Q9NYA3 32296183
Intra
HOXB5 P09067 GOLGA6A Homo sapiens Q9NYA3 32296183
Intra
HOXB5 P09067 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
HOXB5 P09067 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
HOXB5 P09067 MTUS2 Homo sapiens Q5JR59-3 32296183
Intra
HOXB5 P09067 TEX11 Homo sapiens Q8IYF3-3 32296183
Intra
HOXB5 P09067 TEX11 Homo sapiens Q8IYF3-3 32296183
Intra
HOXB5 P09067 TEX11 Homo sapiens Q8IYF3-3 32296183
Intra
HOXB5 P09067 CARD9 Homo sapiens Q9H257-2 32296183
Intra
HOXB5 P09067 CARD9 Homo sapiens Q9H257-2 32296183
Intra
HOXB5 P09067 CARD9 Homo sapiens Q9H257-2 32296183
Intra
HOXB5 P09067 TLE5 Homo sapiens Q08117-2 32296183
Intra
HOXB5 P09067 TLE5 Homo sapiens Q08117-2 32296183
Intra
HOXB5 P09067 TLE5 Homo sapiens Q08117-2 32296183
Intra
HOXB5 P09067 KRTAP1-1 Homo sapiens Q07627 32296183
Intra
HOXB5 P09067 KRTAP1-1 Homo sapiens Q07627 32296183
Intra
HOXB5 P09067 KRTAP1-1 Homo sapiens Q07627 32296183
Intra
HOXB5 P09067 KRTAP10-6 Homo sapiens P60371 32296183
Intra
HOXB5 P09067 KRTAP10-6 Homo sapiens P60371 32296183
Intra
HOXB5 P09067 KRTAP10-6 Homo sapiens P60371 32296183
Intra
HOXB5 P09067 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
HOXB5 P09067 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
HOXB5 P09067 ZMYND12 Homo sapiens Q9H0C1 32296183
Intra
HOXB5 P09067 CNFN Homo sapiens Q9BYD5 32296183
Intra
HOXB5 P09067 CNFN Homo sapiens Q9BYD5 32296183
Intra
HOXB5 P09067 CNFN Homo sapiens Q9BYD5 32296183
Intra
HOXB5 P09067 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
HOXB5 P09067 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
HOXB5 P09067 MEOX2 Homo sapiens Q6FHY5 32296183
Intra
HOXB5 P09067 SIRT1 Homo sapiens Q96EB6 33961781
Intra
HOXB5 P09067 SIRT1 Homo sapiens Q96EB6 28514442
Intra
HOXB5 P09067 TRIM54 Homo sapiens Q9BYV2 32296183
Intra
HOXB5 P09067 TRIM54 Homo sapiens Q9BYV2 32296183
Intra
HOXB5 P09067 TRIM54 Homo sapiens Q9BYV2 32296183
Intra
HOXB5 P09067 KRTAP6-3 Homo sapiens Q3LI67 32296183
Intra
HOXB5 P09067 KRTAP6-3 Homo sapiens Q3LI67 32296183
Intra
HOXB5 P09067 PHF19 Homo sapiens Q5T6S3 32296183
Intra
HOXB5 P09067 PHF19 Homo sapiens Q5T6S3 32296183
Intra
HOXB5 P09067 PHF19 Homo sapiens Q5T6S3 32296183
Intra
HOXB5 P09067 ZNF552 Homo sapiens Q9H707 32296183
Intra
HOXB5 P09067 ZNF552 Homo sapiens Q9H707 32296183
Intra
HOXB5 P09067 ZNF552 Homo sapiens Q9H707 32296183
Intra
HOXB5 P09067 VPS52 Homo sapiens Q8N1B4 32296183
Intra
HOXB5 P09067 VPS52 Homo sapiens Q8N1B4 32296183
Intra
HOXB5 P09067 VPS52 Homo sapiens Q8N1B4 32296183
Intra
HOXB5 P09067 PBX1 Homo sapiens P40424 32296183
Intra
HOXB5 P09067 PBX1 Homo sapiens P40424 32296183
Intra
HOXB5 P09067 PBX1 Homo sapiens P40424 32296183
Intra
HOXB5 P09067 PLXND1 Homo sapiens Q9Y4D7 32296183
Intra
HOXB5 P09067 PLXND1 Homo sapiens Q9Y4D7 32296183
Intra
HOXB5 P09067 PLXND1 Homo sapiens Q9Y4D7 32296183
Intra
HOXB5 P09067 CCDC88B Homo sapiens A6NC98 32296183
Intra
HOXB5 P09067 CCDC88B Homo sapiens A6NC98 32296183
Intra
HOXB5 P09067 CSNK2B Homo sapiens P67870 32296183
Intra
HOXB5 P09067 CSNK2B Homo sapiens P67870 32296183
Intra
HOXB5 P09067 CSNK2B Homo sapiens P67870 32296183
Intra
HOXB5 P09067 PBX2 Homo sapiens P40425 32296183
Intra
HOXB5 P09067 PBX2 Homo sapiens P40425 32296183
Intra
HOXB5 P09067 PBX2 Homo sapiens P40425 32296183
Intra
HOXB5 P09067 TRAF2 Homo sapiens Q12933 32296183
Intra
HOXB5 P09067 TRAF2 Homo sapiens Q12933 32296183
Intra
HOXB5 P09067 TRAF2 Homo sapiens Q12933 32296183
Intra
HOXB5 P09067 TRAF1 Homo sapiens Q13077 32296183
Intra
HOXB5 P09067 TRAF1 Homo sapiens Q13077 32296183
Intra
HOXB5 P09067 TRAF1 Homo sapiens Q13077 32296183
Intra
HOXB5 P09067 TRAF4 Homo sapiens Q9BUZ4 32296183
Intra
HOXB5 P09067 TRAF4 Homo sapiens Q9BUZ4 32296183
Intra
HOXB5 P09067 TRAF4 Homo sapiens Q9BUZ4 32296183
Intra
HOXB5 P09067 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
HOXB5 P09067 CYSRT1 Homo sapiens A8MQ03 32296183
Intra
HOXB5 P09067 PRDM14 Homo sapiens Q9GZV8 32296183
Intra
HOXB5 P09067 PRDM14 Homo sapiens Q9GZV8 32296183
Intra
HOXB5 P09067 PRDM14 Homo sapiens Q9GZV8 32296183
Intra
HOXB5 P09067 AXIN2 Homo sapiens Q9Y2T1 32296183
Intra
HOXB5 P09067 AXIN2 Homo sapiens Q9Y2T1 32296183
Intra
HOXB5 P09067 AXIN2 Homo sapiens Q9Y2T1 32296183
Intra
HOXB5 P09067 TRIB3 Homo sapiens Q96RU7 32296183
Intra
HOXB5 P09067 TRIB3 Homo sapiens Q96RU7 32296183
Intra
HOXB5 P09067 TRIB3 Homo sapiens Q96RU7 32296183
Intra
HOXB5 P09067 ZRANB1 Homo sapiens Q9UGI0 32296183
Intra
HOXB5 P09067 ZRANB1 Homo sapiens Q9UGI0 32296183
Intra
HOXB5 P09067 ZRANB1 Homo sapiens Q9UGI0 32296183
Intra
HOXB5 P09067 OIP5 Homo sapiens O43482 32296183
Intra
HOXB5 P09067 OIP5 Homo sapiens O43482 32296183
Intra
HOXB5 P09067 GOLGA6L9 Homo sapiens A6NEM1 32296183
Intra
HOXB5 P09067 GOLGA6L9 Homo sapiens A6NEM1 32296183
Intra
HOXB5 P09067 GOLGA2 Homo sapiens Q08379 32296183
Intra
HOXB5 P09067 GOLGA2 Homo sapiens Q08379 32296183
Intra
HOXB5 P09067 GOLGA2 Homo sapiens Q08379 32296183
Intra
HOXB5 P09067 ZNF655 Homo sapiens Q8N720 32296183
Intra
HOXB5 P09067 ZNF655 Homo sapiens Q8N720 32296183
Intra
HOXB5 P09067 ZNF655 Homo sapiens Q8N720 32296183
Intra
HOXB5 P09067 ASB6 Homo sapiens Q9NWX5 32296183
Intra
HOXB5 P09067 ASB6 Homo sapiens Q9NWX5 32296183
Intra
HOXB5 P09067 ASB6 Homo sapiens Q9NWX5 32296183
Intra
HOXB5 P09067 HSF2BP Homo sapiens O75031 32296183
Intra
HOXB5 P09067 HSF2BP Homo sapiens O75031 32296183
Intra
HOXB5 P09067 HAP1 Homo sapiens P54257 32296183
Intra
HOXB5 P09067 HAP1 Homo sapiens P54257 32296183
Intra
HOXB5 P09067 HAP1 Homo sapiens P54257 32296183
Intra
HOXB5 P09067 TRIM27 Homo sapiens P14373 32296183
Intra
HOXB5 P09067 TRIM27 Homo sapiens P14373 32296183
Intra
HOXB5 P09067 TRIM27 Homo sapiens P14373 32296183
Intra
HOXB5 P09067 MAGEA11 Homo sapiens P43364 32296183
Intra
HOXB5 P09067 MAGEA11 Homo sapiens P43364 32296183
Intra
HOXB5 P09067 MAGEA11 Homo sapiens P43364 32296183
Intra
HOXB5 P09067 CALCOCO2 Homo sapiens Q13137 32296183
Intra
HOXB5 P09067 CALCOCO2 Homo sapiens Q13137 32296183
Intra
HOXB5 P09067 CALCOCO2 Homo sapiens Q13137 32296183
Intra
HOXB5 P09067 CEP70 Homo sapiens Q8NHQ1 32296183
Intra
HOXB5 P09067 CEP70 Homo sapiens Q8NHQ1 32296183
Intra
HOXB5 P09067 CEP70 Homo sapiens Q8NHQ1 32296183
Intra
HOXB5 P09067 TRIM23 Homo sapiens P36406 32296183
Intra
HOXB5 P09067 TRIM23 Homo sapiens P36406 32296183
Intra
HOXB5 P09067 TRIM23 Homo sapiens P36406 32296183
Intra
HOXB5 P09067 TRIM23 Homo sapiens P36406 25416956
Intra
HOXB5 P09067 LDOC1 Homo sapiens O95751 32296183
Intra
HOXB5 P09067 LDOC1 Homo sapiens O95751 32296183
Intra
HOXB5 P09067 ZC4H2 Homo sapiens Q9NQZ6 32296183
Intra
HOXB5 P09067 ZC4H2 Homo sapiens Q9NQZ6 32296183
Intra
HOXB5 P09067 ZC4H2 Homo sapiens Q9NQZ6 32296183
Intra
HOXB5 P09067 HOMER3 Homo sapiens Q9NSC5 32296183
Intra
HOXB5 P09067 HOMER3 Homo sapiens Q9NSC5 32296183
Intra
HOXB5 P09067 HOMER3 Homo sapiens Q9NSC5 32296183
Intra
HOXB5 P09067 TEKT4 Homo sapiens Q8WW24 32296183
Intra
HOXB5 P09067 TEKT4 Homo sapiens Q8WW24 32296183
Intra
HOXB5 P09067 TEKT4 Homo sapiens Q8WW24 32296183
Intra
HOXB5 P09067 USH1G Homo sapiens Q495M9 32296183
Intra
HOXB5 P09067 USH1G Homo sapiens Q495M9 32296183
Intra
HOXB5 P09067 USH1G Homo sapiens Q495M9 32296183
Intra
HOXB5 P09067 KRT31 Homo sapiens Q15323 32296183
Intra
HOXB5 P09067 KRT31 Homo sapiens Q15323 32296183
Intra
HOXB5 P09067 KRT31 Homo sapiens Q15323 32296183
Intra
HOXB5 P09067 KIFAP3 Homo sapiens Q92845 32296183
Intra
HOXB5 P09067 KIFAP3 Homo sapiens Q92845 32296183
Intra
HOXB5 P09067 KIFAP3 Homo sapiens Q92845 32296183
Intra
HOXB5 P09067 PDE4DIP Homo sapiens Q5VU43-2 32296183
Intra
HOXB5 P09067 PDE4DIP Homo sapiens Q5VU43-2 32296183
Intra
HOXB5 P09067 PDE4DIP Homo sapiens Q5VU43-2 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

HOXB5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810889 HOXB5 Antibody WB, ICC/IF Human, Mouse, Rat
HY-P89842 HoxB5 Antibody (YA9186) WB, IP human

Related Diseases

Diseases Alias
Hereditary Lymphedema Ia
  • Lmph1a

  • Lymphedema, Hereditary, Ia

  • Milroy Disease

Barrett Esophagus
  • Barrett'S Esophagus

  • Barrett Esophagus/Esophageal Adenocarcinoma

  • Barrett Metaplasia

  • Barrett'S Ulcer Of Esophagus

  • Ulcerative Esophagitis

  • Barrett'S Esophagus With Esophagitis

  • Barrett'S Oesophagus

  • Barretts Syndrome

  • Barrett Syndrome

  • BE

  • Peptic Ulcer Of Esophagus

  • Adenocarcinoma Of Esophagus

Hirschsprung Disease 1
  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon

Congenital Central Hypoventilation Syndrome
  • Cchs

  • Haddad Syndrome

  • Ondine Curse

  • Ondine Syndrome

  • Congenital Central Hypoventilation

  • Congenital Central Alveolar Hypoventilation Syndrome

  • Congenital Failure Of Autonomic Control

  • Ondine'S Curse

  • Primary Alveolar Hypoventilation

  • Ondine-Hirschsprung Disease

  • Central Congenital Hypoventilation Syndrome

  • Congenital Ondine Curse

  • Idiopathic Congenital Central Alveolar Hypoventilation

  • Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome

  • Ondine-Hirschsprung Syndrome

Diaphragmatic Hernia, Congenital
  • Congenital Diaphragmatic Hernia

  • Diaphragmatic Hernia

  • Cdh

  • Congenital Diaphragmatic Defect

  • Hernia, Diaphragmatic

  • Dih

  • Hernia, Congenital Diaphragmatic

  • Hcd

  • Diaphragmatic Defect, Congenital

  • Diaphragm, Unilateral Agenesis Of

  • Hemidiaphragm, Agenesis Of

  • Diaphragmatic Hernia 1

  • Agenesis Of Hemidiaphragm

  • Unilateral Agenesis Of Diaphragm

  • Hernia Diaphragmatic

  • Hernia Diaphragmatic Congenital

  • Hernia, Diaphragmatic, Type 1

  • Hiatus Hernia

  • Oesophageal Hiatus Hernia

  • Paraoesophageal Hernia

  • Sliding Hiatus Hernia

  • Congenital Diaphragm Hernia

  • Congenital Diaphragm Defect With Hernia

  • Gross Congenital Diaphragm Defect

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus HOXB5 VGNC VGNC:58381
Rattus norvegicus HOXB5 RGD RGD:1562292
Canis familiaris HOXB5 VGNC VGNC:54956
Macaca mulatta HOXB5 VGNC VGNC:104619
Felis catus HOXB5 VGNC VGNC:99080
Mus musculus HOXB5 MGD MGI:96186
Others HOXB5 NCBI