PRDM14 - PR/SET domain 14 Gene

Also Known as PFM11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 63978

About PRDM14

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:70,051,651-70,071,252 (from NCBI)

This gene has 2 transcripts (splice variants), 195 orthologues and 36 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the PRDI-BF1 and RIZ homology domain containing (PRDM) family of transcriptional regulators. The encoded protein may possess Histone Methyltransferase activity and plays a critical role in cell pluripotency by suppressing the expression of differentiation marker genes. Expression of this gene may play a role in breast Cancer. [provided by RefSeq, Dec 2011]

PRDM14 Products (1)

mRNA	Protein	Name
NM_024504.4	NP_078780.1	PR domain zinc finger protein 14

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDM14 Protein Structure

SET

zf-C2H2_4

zf-H2C2_2

zf-C2H2

0
100
200
300
400
500
571 a.a.

Protein Preferred Names	Protein Names
PR domain zinc finger protein 14	PR domain 14

PRDM14 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRDM14	Q9GZV8	RUNX1T1	Homo sapiens	Q06455-4	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	PRDM14	Q9GZV8	RUNX1T1	Homo sapiens	Q06455-4	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	MIA3	Homo sapiens	Q5JRA6-2	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	MIA3	Homo sapiens	Q5JRA6-2	Validated Y2H	25416956
Intra	PRDM14	Q9GZV8	RAD51D	Homo sapiens	O75771	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	RAD51D	Homo sapiens	O75771	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	PATZ1	Homo sapiens	Q9HBE1-4	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439-4	Anti Tag CoIP	28514442
Intra	PRDM14	Q9GZV8	GPATCH2L	Homo sapiens	Q9NWQ4-1	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	TCAF1	Homo sapiens	Q9Y4C2-2	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	RUNX1T1	Homo sapiens	Q06455-2	Anti Tag CoIP	28514442
Intra	PRDM14	Q9GZV8	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Cross	PRDM14	Q9GZV8	Hoxa1	Mus musculus	P09022	Y2H	23088713
Intra	PRDM14	Q9GZV8	EIF4E2	Homo sapiens	O60573	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	HEXIM2	Homo sapiens	Q96MH2	Y2H	21516116
Intra	PRDM14	Q9GZV8	HEXIM2	Homo sapiens	Q96MH2	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	GPATCH2L	Homo sapiens	Q9NWQ4	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	GPATCH2L	Homo sapiens	Q9NWQ4	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	ZNF835	Homo sapiens	Q9Y2P0	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	HSPB7	Homo sapiens	Q9UBY9	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	HSPB7	Homo sapiens	Q9UBY9	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	RUNX1T1	Homo sapiens	Q06455	Anti Tag CoIP	33961781
Intra	PRDM14	Q9GZV8	RCOR3	Homo sapiens	Q9P2K3	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	PRDM14	Q9GZV8	BEX2	Homo sapiens	Q9BXY8	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	BEX2	Homo sapiens	Q9BXY8	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	MAPPIT	25416956
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Anti Tag CoIP	25416956
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Anti Bait CoIP	27281218
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	GMS	27281218
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Anti Tag CoIP	33961781
Intra	PRDM14	Q9GZV8	CBFA2T2	Homo sapiens	O43439	Anti Tag CoIP	27281218
Intra	PRDM14	Q9GZV8	TEKT4	Homo sapiens	Q8WW24	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	TTC32	Homo sapiens	Q5I0X7	Validated Y2H	25416956
Intra	PRDM14	Q9GZV8	TTC32	Homo sapiens	Q5I0X7	Y2H Array	25416956
Intra	PRDM14	Q9GZV8	TTC32	Homo sapiens	Q5I0X7	Y2H Prey Pooling	25416956
Intra	PRDM14	Q9GZV8	DMRT3	Homo sapiens	Q9NQL9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

PRDM14 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84783	PRDM14 Antibody (YA4480)	WB, FC, ELISA	Human
HY-P84783A	PRDM14 Antibody (YA4480)(PBS only)	WB, FC, ELISA	Human

Related Diseases

Diseases	Alias
Malignant Pineal Area Germ Cell Neoplasm	Pineal Germ Cell Tumor Malignant Pineal Parenchymal Germ Cell Tumor Pineal Region Germ Cell Tumor Pineal Cell Tumor Pineal Cell Tumour Pineal Region Germinoma Malignant Pineal Region Germ Cell Tumor Pineal Germinoma
Brain Germinoma	Intracranial Germinoma Germinoma Of The Brain
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Pineal Region Germinoma	Pineal Germinoma
Malignant Teratoma	Immature Teratoma Malignant Extragonadal Teratoma Primary Malignant Extragonadal Teratoma Teratoma, Malignant, Nos Teratoma, Malignant Immature Extragonadal Teratoma
Testicular Germ Cell Cancer	Germ Cell Tumor Of Testis Testicular Germ Cell Tumor Testicular Germ Cell Neoplasm Testicular Malignant Germ Cell Tumor
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11064	PRDM14 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-13689G	Go 6983 (GMP)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PRDM14	VGNC	VGNC:44946
Rattus norvegicus	PRDM14	RGD	RGD:2319590
Mus musculus	PRDM14	MGD	MGI:3588194
Bos taurus	PRDM14	VGNC	VGNC:33292
Felis catus	PRDM14	VGNC	VGNC:64345
Macaca mulatta	PRDM14	VGNC	VGNC:104473
Others	PRDM14	NCBI