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RCOR3 - REST corepressor 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55758

About RCOR3

This gene has 16 transcripts (splice variants), 191 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 13.7), thyroid (RPKM 11.6) and 25 other tissues.

Summary

Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription, DNA-templated; and regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RCOR3 Products (6)

mRNA	Protein	Name
NM_001136223.3	NP_001129695.1	REST corepressor 3 isoform a
NM_001136224.4	NP_001129696.2	REST corepressor 3 isoform b
NM_001136225.3	NP_001129697.1	REST corepressor 3 isoform c
NM_001350069.2	NP_001336998.1	REST corepressor 3 isoform e
NM_001350070.2	NP_001336999.1	REST corepressor 3 isoform f
NM_018254.5	NP_060724.1	REST corepressor 3 isoform d

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RCOR3 Protein Structure

ELM2

Myb_DNA-binding

0
100
200
300
400
495 a.a.

Protein Preferred Names	Protein Names
REST corepressor 3

RCOR3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RCOR3	Q9P2K3	CCDC102B	Homo sapiens	Q68D86	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	CCDC102B	Homo sapiens	Q68D86	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	LUZP4	Homo sapiens	Q9P127	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	MAGEA6	Homo sapiens	P43360	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	MAGEA6	Homo sapiens	P43360	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	CDR2	Homo sapiens	Q01850	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	TRAF2	Homo sapiens	Q12933	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	TRAF2	Homo sapiens	Q12933	Y2H	21516116
Intra	RCOR3	Q9P2K3	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	GSE1	Homo sapiens	Q14687	Y2H Array	29892012
Intra	RCOR3	Q9P2K3	GSE1	Homo sapiens	Q14687	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	GSE1	Homo sapiens	Q14687	Y2H Array	19060904
Intra	RCOR3	Q9P2K3	GSE1	Homo sapiens	Q14687	Lumier	32814053
Intra	RCOR3	Q9P2K3	GSE1	Homo sapiens	Q14687	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	GSE1	Homo sapiens	Q14687	Y2H Pooling	19060904
Intra	RCOR3	Q9P2K3	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	LCA5	Homo sapiens	Q86VQ0	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	LCA5	Homo sapiens	Q86VQ0	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	NINL	Homo sapiens	Q9Y2I6	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	NINL	Homo sapiens	Q9Y2I6	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	KRT15	Homo sapiens	P19012	Pull Down	16189514
Intra	RCOR3	Q9P2K3	KRT15	Homo sapiens	P19012	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	TSGA10	Homo sapiens	Q9BZW7	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	25416956
Intra	RCOR3	Q9P2K3	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	25416956
Intra	RCOR3	Q9P2K3	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	CEP55	Homo sapiens	Q53EZ4	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	RCOR3	Q9P2K3	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Retinitis Pigmentosa 29	RP29

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11793	RCOR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RCOR3	RGD	RGD:1593864
Bos taurus	RCOR3	VGNC	VGNC:33836
Mus musculus	RCOR3	MGD	MGI:2441920
Macaca mulatta	RCOR3	VGNC	VGNC:76824
Felis catus	RCOR3	VGNC	VGNC:64553
Canis familiaris	RCOR3	VGNC	VGNC:45448
Others	RCOR3	NCBI