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  3. IKZF3 - IKAROS family zinc finger 3 Gene

IKZF3 - IKAROS family zinc finger 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as AIO; IMD84; AIOLOS; ZNFN1A3

Gene ID: 22806 | Gene type: protein coding

About IKZF3

Cytogenetic location: 17q12-q21.1 Genomic coordinates (GRCh38): 17:39,757,715-39,864,312 (from NCBI)

This gene has 17 transcripts (splice variants), 133 orthologues, 11 paralogues and is associated with 71 phenotypes. Biased expression in lymph node (RPKM 17.4), spleen (RPKM 11.5) and 10 other tissues.

Summary

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

IKZF3 Products(16)

mRNA Protein Name
NM_001257408.2 NP_001244337.1 zinc finger protein Aiolos isoform 7
NM_001257409.2 NP_001244338.1 zinc finger protein Aiolos isoform 8
NM_001257410.2 NP_001244339.1 zinc finger protein Aiolos isoform 9
NM_001257411.2 NP_001244340.1 zinc finger protein Aiolos isoform 10
NM_001257412.2 NP_001244341.1 zinc finger protein Aiolos isoform 11
NM_001257413.2 NP_001244342.1 zinc finger protein Aiolos isoform 12
NM_001257414.2 NP_001244343.1 zinc finger protein Aiolos isoform 13
NM_001284514.2 NP_001271443.1 zinc finger protein Aiolos isoform 14
NM_001284515.2 NP_001271444.1 zinc finger protein Aiolos isoform 14
NM_001284516.1 NP_001271445.1 zinc finger protein Aiolos isoform 14
NM_012481.5 NP_036613.2 zinc finger protein Aiolos isoform 1
NM_183228.3 NP_899051.1 zinc finger protein Aiolos isoform 2
NM_183229.3 NP_899052.1 zinc finger protein Aiolos isoform 3
NM_183230.3 NP_899053.1 zinc finger protein Aiolos isoform 4
NM_183231.3 NP_899054.1 zinc finger protein Aiolos isoform 5
NM_183232.3 NP_899055.1 zinc finger protein Aiolos isoform 6

IKZF3 Protein Structure

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (133 - 156)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (160 - 182)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (189 - 212)

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  • 509 a.a.
Protein Preferred Names Protein Names

zinc finger protein Aiolos

zinc finger DNA binding protein Aiolos

Related Diseases

Diseases Alias
Immunodeficiency 84

IMD84
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Gestational Ovarian Choriocarcinoma
T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0003 Lenalidomide Inducer 99.91% Yes
HY-A0003B Lenalidomide hemihydrate Inducer 99.67% Yes
HY-A0003A Lenalidomide hydrochloride / Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-130800 Eragidomide 99.86% Phase 2
HY-144841 Cemsidomide 98.94% Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153220 NX-2127 Inhibitor 99.72% Unkown
HY-145319 FPFT-2216 Inhibitor 99.35% Unkown
HY-136262 CRBN-6-5-5-VHL 99.98% Unkown
HY-111594 Homo-PROTAC cereblon degrader 1 99.43% Unkown
HY-144841A (Rac)-Cemsidomide 97.34% Unkown
HY-A0003S Lenalidomide-d5 Inducer 99.32% Unkown
HY-153220A (R)-NX-2127 Degrader / Unkown
HY-RS06667 IKZF3 Human Pre-designed siRNA Set A / Unkown
HY-A0003S2 Lenalidomide-13C5,15N Inducer / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IKZF3 RGD RGD:1307024
Felis catus IKZF3 VGNC VGNC:62900
Canis familiaris IKZF3 VGNC VGNC:41925
Mus musculus IKZF3 MGD MGI:1342542
Macaca mulatta IKZF3 VGNC VGNC:73587
Bos taurus IKZF3 VGNC VGNC:30104