2. Gene
  3. NEK6 - NIMA related kinase 6 Gene

NEK6 - NIMA related kinase 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SID6-1512

Gene ID: 10783 | Gene type: protein coding

About NEK6

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:124,257,606-124,353,307 (from NCBI)

This gene has 15 transcripts (splice variants), 180 orthologues and 8 paralogues. Ubiquitous expression in placenta (RPKM 13.1), appendix (RPKM 13.0) and 25 other tissues.

Summary

The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to Apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NEK6 Products(7)

mRNA Protein Name
NM_001145001.3 NP_001138473.1 serine/threonine-protein kinase Nek6 isoform 1
NM_001166167.2 NP_001159639.1 serine/threonine-protein kinase Nek6 isoform 3
NM_001166168.2 NP_001159640.1 serine/threonine-protein kinase Nek6 isoform 2
NM_001166169.2 NP_001159641.1 serine/threonine-protein kinase Nek6 isoform 4
NM_001166170.2 NP_001159642.1 serine/threonine-protein kinase Nek6 isoform 2
NM_001166171.2 NP_001159643.1 serine/threonine-protein kinase Nek6 isoform 1
NM_014397.6 NP_055212.2 serine/threonine-protein kinase Nek6 isoform 2

NEK6 Protein Structure

Pkinase

Pkinase: Protein kinase domain (45 - 298)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek6

NIMA (never in mitosis gene a)-related kinase 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122639 ZINC05007751 Inhibitor 98.47% Unkown
HY-RS09197 NEK6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NEK6 VGNC VGNC:75311
Bos taurus NEK6 VGNC VGNC:31997
Felis catus NEK6 VGNC VGNC:68459
Canis familiaris NEK6 VGNC VGNC:43733
Mus musculus NEK6 MGD MGI:1891638
Rattus norvegicus NEK6 RGD RGD:727779
Others NEK6 NCBI