country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184863

Copy Link Print Information

PLK1-IN-17

PLK1-IN-17 is a potent PLK1 inhibitor with an IC₅₀ of 2 nM. PLK1-IN-17 shows high selectivity for PLK2 and CDK2/A, moderate selectivity for PLK3, only weak activity against CK2, FLT3 and NEK6, and no activity against PDGFR, ALK and another 37 kinases. PLK1-IN-17 inhibits the proliferation of ovarian cancer cells and can be used in ovarian cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 1034617-66-7
Formula: C₂₂H₂₃F₃N₈O₂
Molecular Weight:488.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PLK1-IN-17 Chemical Structure

CAS No.: 1034617-66-7

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PLK1

2 nM (IC₅₀)

FLT3

194 nM (IC₅₀)

CK2

59 nM (IC₅₀)

NEK6

595 nM (IC₅₀)

All Polo-like Kinase (PLK) Isoforms :

All Casein Kinase Isoforms :

All NEKs Isoforms :

In Vitro

PLK1-IN-17 potently inhibits recombinant PLK1 with an IC₅₀ of 0.002 μM, while showing high selectivity over PLK2, CDK2/A, and moderate selectivity over PLK3^[1].
PLK1-IN-17 potently inhibits PLK1 with an IC₅₀ of 0.002 μM, shows weak activity against CK2, FLT3, and NEK6, and is inactive against PDGFR, ALK, and 37 additional tested kinases^[1].
PLK1-IN-17 inhibits A2780 ovarian carcinoma cell proliferation with an IC₅₀ of 0.03 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1034617-66-7
Molecular Weight 488.47
Formula C₂₂H₂₃F₃N₈O₂
SMILES

O=C(C1=NN(C)C2=C1CCC3=C2N=C(NC4=CC(N5CCNCC5)=CC=C4OC(F)(F)F)N=C3)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Beria I, et al. 4, 5-Dihydro-1H-pyrazolo [4, 3-h] quinazolines as potent and selective Polo-like kinase 1 (PLK1) inhibitors[J]. Bioorganic & medicinal chemistry letters, 2010, 20(22): 6489-6494.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

PLK1-IN-17

All Polo-like Kinase (PLK) Isoforms

All Casein Kinase Isoforms

All NEKs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PLK1-IN-17 Related Classifications

HY-184863 Related Classifications