NEK6
NEK6 operates in M phase as a downstream effector of the master mitotic kinase NEK9, which phosphorylates and activates both NEK6 and NEK7. NEK6 is required for normal spindle formation and chromosome segregation, and its depletion causes mitotic arrest with spindle defects and apoptosis. The kinase localizes dynamically between nucleus and spindle apparatus and has been connected to regulation of mitotic microtubule dynamics and to DNA-damage-related signaling; reported substrates include β-tubulin. NEK6 expression is elevated in several cancers, supporting its interest as an antimitotic target. Recombinant NEK6 supports mitotic-kinase cascade studies.
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NEK6 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
