1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. Polo-like Kinase (PLK) Inhibitors

Polo-like Kinase (PLK) Inhibitors

PLK1

PLK2

PLK3

PLK4

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Polo-like Kinase (PLK) Degraders & Inhibitors
Product Name PLK1 PLK2 PLK3 PLK4 Purity
Wortmannin    
PLK3, IC50: 48 nM
  99.86%
BI 2536
PLK1, IC50: 0.83 nM
Plk2/Snk, IC50: 3.5 nM
Plk3/Fnk, IC50: 9 nM
  99.95%
Volasertib
PLK1, IC50: 0.87 nM
PLK2, IC50: 5 nM
PLK3, IC50: 56 nM
  99.41%
Onvansertib
PLK1, IC50: 2 nM
      99.55%
Centrinone      
PLK4, Ki: 0.16 nM
PLK4 (G95L), Ki: 68.57 nM
98.57%
Ocifisertib      
PLK4, IC50: 2.8 nM
98.45%
PROTAC PLK1 Degrader-1
PLK1
     
GSK461364
PLK1, Ki: 2.2 nM
      99.82%
Centrinone-B      
PLK4, Ki: 0.59 nM
PLK4 (G95L), Ki: 497.53 nM
98.71%
Rigosertib
PLK1, IC50: 9 nM
PLK2, IC50: 260 nM
    98.35%
Rigosertib sodium
PLK1, IC50: 9 nM
PLK2, IC50: 260 nM
    99.57%
GW843682X
PLK1, IC50: 2.2 nM
 
PLK3, IC50: 9.1 nM
  99.75%
Ro3280
PLK1, Kd: 0.09 nM
      98.87%
TAK-960
PLK1, IC50: 0.8 nM
PLK2, IC50: 16.9 nM
PLK3, IC50: 50.2 nM
  99.75%
(Z)-LFM-A13
Plx1, IC50: 10 μM
 
PLK3, IC50: 61 μM
  99.97%
MLN0905
PLK1, IC50: 2 nM
      99.94%
HMN-214
PLK1
      99.25%
TC-S 7005
PLK1, IC50: 214 nM
PLK2, IC50: 4 nM
PLK3, IC50: 24 nM
  99.56%
(1E)-CFI-400437 dihydrochloride      
PLK4, IC50: 0.6 nM
98.89%
Poloxin
PLK1 PBD, IC50: 4.8 μM
PLK2 PBD, IC50: 18.7 μM
PLK3 PBD, IC50: 53.9 μM
  98.01%
Plogosertib
PLK1, IC50: 3 nM
PLK2, IC50: 149 nM
PLK3, IC50: 393 nM
  99.95%
SBE13 Hydrochloride
PLK1, IC50: 200 pM
 
PLK3, IC50: 875 nM
  99.66%
TAK-960 dihydrochloride
PLK1, IC50: 0.8 nM
PLK2, IC50: 16.9 nM
PLK3, IC50: 50.2 nM
  99.19%
Cyclapolin 9
PLK1, IC50: 500 nM
      99.16%
Dihydrobaicalein
PLK1
      99.94%
LFM-A13
Plx1, IC50: 10 μM
 
PLK3, IC50: 61 μM
 
SBE13
PLK1, IC50: 200 pM
 
PLK3, IC50: 875 nM
 
Poloxime
PLK1
     
Volasertib trihydrochloride
PLK1, IC50: 0.87 nM
PLK2, IC50: 5 nM
PLK3, IC50: 56 nM
 
(E/Z)-Rigosertib sodium
PLK1
     
BTO-1
Plx1
     
PLK1-IN-6
PLK1, IC50: 0.45 nM
PLK2, IC50: 5.73 nM
PLK3, IC50: 7.56 nM
 
PLK1/BRD4-IN-1
PLK1, IC50: 22 nM
     
PLK1/BRD4-IN-5
PLK1, IC50: 0.3 nM
     
PLK4-IN-4      
PLK4, IC50: 7.9 nM
YLT-11
PLK1, Kd: >10000 nM
PLK2, Kd: 653 nM
PLK3, Kd: >10000 nM
PLK4, Kd: 5.2 nM
PLK4-IN-3      
PLK4, IC50: ≤ 0.1 μM
CZS-241      
PLK4, IC50: 2.6 nM
PLK1-IN-5
PLK1, IC50: <500 nM
     
TAK-960 hydrochloride
PLK1, IC50: 0.8 nM
PLK2, IC50: 16.9 nM
PLK3, IC50: 50.2 nM