1034617-66-7
1034617-66-7
Chemical Structure
PLK1-IN-17
- CAS 番号: 1034617-66-7
- Formula:C22H23F3N8O2
- Molecular Weight:488.47
InChIKey: TUWAYASUNDRSML-UHFFFAOYSA-N
SMILES: O=C(C1=NN(C)C2=C1CCC3=C2N=C(NC4=CC(N5CCNCC5)=CC=C4OC(F)(F)F)N=C3)N
Biological Activity: PLK1-IN-17 is a potent PLK1 inhibitor with an IC50 of 2 nM. PLK1-IN-17 shows high selectivity for PLK2 and CDK2/A, moderate selectivity for PLK3, only weak activity against CK2, FLT3 and NEK6, and no activity against PDGFR, ALK and another 37 kinases. PLK1-IN-17 inhibits the proliferation of ovarian cancer cells and can be used in ovarian cancer-related research[1].
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PLK1-IN-17 | PLK1-IN-17 is a potent PLK1 inhibitor with an IC50 of 2 nM. PLK1-IN-17 shows high selectivity for PLK2 and CDK2/A, moderate selectivity for PLK3, only weak activity against CK2, FLT3 and NEK6, and no activity against PDGFR, ALK and another 37 kinases. PLK1-IN-17 inhibits the proliferation of ovarian cancer cells and can be used in ovarian cancer-related research. | |||||||||||||||||||||
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References
Keywords
