IKZF1 - IKAROS family zinc finger 1 Gene

Also Known as IK1; LYF1; LyF-1; CVID13; IKAROS; PPP1R92; PRO0758; ZNFN1A1; Hs.54452

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10320

About IKZF1

Cytogenetic location: 7p12.2 Genomic coordinates (GRCh38): 7:50,303,455-50,405,101 (from NCBI)

This gene has 22 transcripts (splice variants), 209 orthologues, 11 paralogues and is associated with 106 phenotypes. Biased expression in lymph node (RPKM 13.3), appendix (RPKM 8.6) and 10 other tissues.

Summary

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with Other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

IKZF1 Products (18)

mRNA	Protein	Name
NM_001220765.3	NP_001207694.1	DNA-binding protein Ikaros isoform 2
NM_001220767.2	NP_001207696.1	DNA-binding protein Ikaros isoform 4
NM_001220768.2	NP_001207697.1	DNA-binding protein Ikaros isoform 5
NM_001220770.2	NP_001207699.1	DNA-binding protein Ikaros isoform 7
NM_001220771.2	NP_001207700.1	DNA-binding protein Ikaros isoform 8
NM_001291837.2	NP_001278766.1	DNA-binding protein Ikaros isoform 2
NM_001291838.2	NP_001278767.1	DNA-binding protein Ikaros isoform 3
NM_001291839.2	NP_001278768.1	DNA-binding protein Ikaros isoform 6
NM_001291840.1	NP_001278769.1	DNA-binding protein Ikaros isoform Ik-6
NM_001291841.1	NP_001278770.1	DNA-binding protein Ikaros isoform Ik-7
NM_001291842.1	NP_001278771.1	DNA-binding protein Ikaros isoform Ik-7(del)
NM_001291843.1	NP_001278772.1	DNA-binding protein Ikaros isoform Ik-8
NM_001291844.1	NP_001278773.1	DNA-binding protein Ikaros isoform Ik-8(del)
NM_001291845.2	NP_001278774.1	DNA-binding protein Ikaros isoform 15
NM_001291846.2	NP_001278775.1	DNA-binding protein Ikaros isoform 16
NM_001291847.2	NP_001278776.1	DNA-binding protein Ikaros isoform 16
NM_001410879.1	NP_001397808.1	DNA-binding protein Ikaros isoform 17
NM_006060.6	NP_006051.1	DNA-binding protein Ikaros isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	21548011	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15491138	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15491138	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17934067	GOA
involved in lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	17934067	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	21548011	GOA
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	21548011	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23071339	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15491138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IKZF1 Protein Structure

zf-H2C2_2

0
100
200
300
400
519 a.a.

Protein Preferred Names	Protein Names
DNA-binding protein Ikaros	CLL-associated antigen KW-6

IKZF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IKZF1	Q13422	CTBP1	Homo sapiens	Q13363-2	Validated Y2H	25416956
Intra	IKZF1	Q13422	CTBP2	Homo sapiens	P56545-3	Validated Y2H	25416956
Intra	IKZF1	Q13422	CTBP2	Homo sapiens	P56545-3	Y2H Array	25416956
Intra	IKZF1	Q13422	a8k932_human	Homo sapiens	A8K932	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	a8k932_human	Homo sapiens	A8K932	Validated Y2H	25416956
Intra	IKZF1	Q13422	a8k932_human	Homo sapiens	A8K932	Y2H Array	25416956
Intra	IKZF1	Q13422	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	25416956
Intra	IKZF1	Q13422	FAM74A4	Homo sapiens	Q5TZK3	Validated Y2H	25416956
Intra	IKZF1	Q13422	SHFL	Homo sapiens	Q9NUL5	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	PNKP	Homo sapiens	Q96T60	Validated Y2H	25416956
Intra	IKZF1	Q13422	PNKP	Homo sapiens	Q96T60	Y2H Array	25416956
Intra	IKZF1	Q13422	ISCU	Homo sapiens	Q9H1K1	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	PRKAB2	Homo sapiens	O43741	Validated Y2H	25416956
Intra	IKZF1	Q13422	PRKAB2	Homo sapiens	O43741	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	RAD51D	Homo sapiens	O75771	Y2H Array	31515488
Intra	IKZF1	Q13422	ZMAT2	Homo sapiens	Q96NC0	Y2H Array	25416956
Intra	IKZF1	Q13422	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	25416956
Intra	IKZF1	Q13422	MCRS1	Homo sapiens	Q96EZ8	Anti Tag CoIP	33961781
Intra	IKZF1	Q13422	DDX6	Homo sapiens	P26196	Validated Y2H	25416956
Intra	IKZF1	Q13422	BYSL	Homo sapiens	Q13895	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	PSMA4	Homo sapiens	P25789	Y2H Array	25416956
Intra	IKZF1	Q13422	PSMA1	Homo sapiens	P25786	Validated Y2H	25416956
Intra	IKZF1	Q13422	PSMA1	Homo sapiens	P25786	Y2H Array	25416956
Intra	IKZF1	Q13422	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	LSM4	Homo sapiens	Q9Y4Z0	Y2H Array	25416956
Intra	IKZF1	Q13422	LSM4	Homo sapiens	Q9Y4Z0	Validated Y2H	25416956
Intra	IKZF1	Q13422	SPATC1L	Homo sapiens	Q9H0A9	Validated Y2H	25416956
Intra	IKZF1	Q13422	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
Intra	IKZF1	Q13422	NOC4L	Homo sapiens	Q9BVI4	Y2H Array	25416956
Intra	IKZF1	Q13422	MORF4L1	Homo sapiens	Q9UBU8	Validated Y2H	25416956
Intra	IKZF1	Q13422	MORF4L1	Homo sapiens	Q9UBU8	Y2H Array	25416956
Intra	IKZF1	Q13422	MORF4L2	Homo sapiens	Q15014	Y2H Array	25416956
Intra	IKZF1	Q13422	CKS1B	Homo sapiens	P61024	Validated Y2H	25416956
Intra	IKZF1	Q13422	CKS1B	Homo sapiens	P61024	Y2H Array	25416956
Intra	IKZF1	Q13422	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	SNW1	Homo sapiens	Q13573	Y2H Array	25416956
Intra	IKZF1	Q13422	SNW1	Homo sapiens	Q13573	Validated Y2H	25416956
Intra	IKZF1	Q13422	FGF12	Homo sapiens	P61328	Y2H Array	25416956
Intra	IKZF1	Q13422	ALKBH3	Homo sapiens	Q96Q83	Y2H Array	29892012
Intra	IKZF1	Q13422	ALKBH3	Homo sapiens	Q96Q83	Y2H Array	31515488
Intra	IKZF1	Q13422	ALKBH3	Homo sapiens	Q96Q83	Validated Y2H	25416956
Intra	IKZF1	Q13422	PIN1	Homo sapiens	Q13526	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	PIN1	Homo sapiens	Q13526	Y2H Array	25416956
Intra	IKZF1	Q13422	MTA1	Homo sapiens	Q13330	Anti Tag CoIP	33961781
Intra	IKZF1	Q13422	MTA1	Homo sapiens	Q13330	Y2H Array	25416956
Intra	IKZF1	Q13422	MTA1	Homo sapiens	Q13330	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	C8orf33	Homo sapiens	Q9H7E9	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	C1orf174	Homo sapiens	Q8IYL3	Y2H Array	31515488
Intra	IKZF1	Q13422	C1orf174	Homo sapiens	Q8IYL3	Y2H Array	25416956
Intra	IKZF1	Q13422	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	IKZF1	Q13422	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	IKZF1	Q13422	FAM161A	Homo sapiens	Q3B820	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	RWDD2B	Homo sapiens	P57060	Y2H	21516116
Intra	IKZF1	Q13422	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	IKZF1	Q13422	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	IKZF1	Q13422	CTBP2	Homo sapiens	P56545	Anti Tag CoIP	33961781
Intra	IKZF1	Q13422	CTBP2	Homo sapiens	P56545	Y2H	21516116
Intra	IKZF1	Q13422	CTBP2	Homo sapiens	P56545	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	CTBP2	Homo sapiens	P56545	Y2H Array	25416956
Intra	IKZF1	Q13422	FRMD6	Homo sapiens	Q96NE9	Validated Y2H	25416956
Intra	IKZF1	Q13422	FRMD6	Homo sapiens	Q96NE9	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	FRMD6	Homo sapiens	Q96NE9	Y2H Array	25416956
Intra	IKZF1	Q13422	FAM50B	Homo sapiens	Q9Y247	Y2H Array	25416956
Intra	IKZF1	Q13422	FAM50B	Homo sapiens	Q9Y247	Y2H	21516116
Intra	IKZF1	Q13422	ARMC7	Homo sapiens	Q9H6L4	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	SYT17	Homo sapiens	Q9BSW7	Y2H Array	25416956
Intra	IKZF1	Q13422	SYT17	Homo sapiens	Q9BSW7	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	25416956
Intra	IKZF1	Q13422	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	25416956
Intra	IKZF1	Q13422	ATOSB	Homo sapiens	Q7L5A3	Y2H Array	29892012
Intra	IKZF1	Q13422	ATOSB	Homo sapiens	Q7L5A3	Y2H Array	31515488
Intra	IKZF1	Q13422	GMCL2	Homo sapiens	Q8NEA9	Y2H Array	25416956
Intra	IKZF1	Q13422	GMCL2	Homo sapiens	Q8NEA9	Validated Y2H	25416956
Intra	IKZF1	Q13422	SCNM1	Homo sapiens	Q9BWG6	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	SCNM1	Homo sapiens	Q9BWG6	Validated Y2H	25416956
Intra	IKZF1	Q13422	DYRK2	Homo sapiens	Q92630	Validated Y2H	25416956
Intra	IKZF1	Q13422	DYRK2	Homo sapiens	Q92630	Y2H Array	25416956
Intra	IKZF1	Q13422	DYRK2	Homo sapiens	Q92630	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	WTAP	Homo sapiens	Q15007	Validated Y2H	25416956
Intra	IKZF1	Q13422	WTAP	Homo sapiens	Q15007	Y2H Array	25416956
Intra	IKZF1	Q13422	WTAP	Homo sapiens	Q15007	Anti Tag CoIP	33961781
Intra	IKZF1	Q13422	WTAP	Homo sapiens	Q15007	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	MAD2L2	Homo sapiens	Q9UI95	Y2H Array	25416956
Intra	IKZF1	Q13422	AEN	Homo sapiens	Q8WTP8	Validated Y2H	25416956
Intra	IKZF1	Q13422	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	25416956
Intra	IKZF1	Q13422	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

IKZF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81282	Ikaros Antibody (YA987)	WB, IP	Human
HY-P81282A	Ikaros Antibody (YA988)	IHC-P	Human
HY-P81282AA	Ikaros Antibody (YA988)(PBS only)	IHC-P	Human
HY-P84541	Ikaros Antibody (YA4238)	ICC/IF, FC, ELISA	Human
HY-P84541A	Ikaros Antibody (YA4238)(PBS only)	ICC/IF, FC, ELISA	Human
HY-P85438	Ikaros Antibody (YA5130)	WB	Human
HY-P85524	Ikaros Antibody (YA5216)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Immunodeficiency, Common Variable, 13	Pancytopenia Due To Ikzf1 Mutations CVID13 Common Variable Immunodeficiency 13 Cid Due To Ikaros Deficiency Combined Immunodeficiency Due To Ikaros Deficiency
Diamond-Blackfan Anemia-Like	DBAL
Severe Cutaneous Adverse Reaction	Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Drug-Induced Stevens Johnson Syndrome Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum Susceptibility To Severe Cutaneous Adverse Reaction Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Lyell'S Syndrome Lyell Syndrome Severe Cutaneous Adverse Reaction, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced, Susceptibility To Hypersensitivity Syndrome, Carbamazepine-Induced Stevens-Johnson Syndrome, Susceptibility To Toxic Epidermal Necrolysis, Susceptibility To Sjs/Ten Susceptibility To Severe Cutaneous Adverse Reaction Ity To Mycoplasma-Induced Stevens Johnson Syndrome Dermatostomatitis, Stevens Johnson Type Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum Sjs-Ten Toxic Epidermolysis SJS Dermatostomatitis Stevens Johnson Type Ten Sjs/Ten - [Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis] Ten - [Toxic Epidermal Necrolysis]
B-Cell Adult Acute Lymphocytic Leukemia	Adult B Acute Lymphoblastic Leukemia Adult B Acute Lymphoblastic Leukaemia Adult B-Cell Acute Lymphoblastic Leukaemia Adult B-Cell Acute Lymphoblastic Leukemia Adult B-Cell Lymphocytic Leukaemia Adult B-Cell Lymphocytic Leukemia Adult B-Lymphoblastic Leukaemia Adult B-Lymphoblastic Leukemia B-Cell Adult Acute Lymphocytic Leukaemia B-Cell Adult Acute Lymphoblastic Leukemia
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Intellectual Developmental Disorder, Autosomal Dominant 33	MRD33 Autosomal Dominant Non-Syndromic Intellectual Disability 33 Mental Retardation, Autosomal Dominant 33 Autosomal Dominant Intellectual Developmental Disorder 33 Autosomal Dominant Mental Retardation 33 Mental Retardation, Autosomal Dominant, Type 33
B-Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like	B Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like B-All Bcr-Abl1-Like
B-Lymphoblastic Leukemia/Lymphoma With Iamp21	B-All With Iamp21 Intrachromosomal Amplification Of Chromosome 21
Pancytopenia
B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1	B-All With Bcr-Abl1 B-Lymphoblastic Leukemia/Lymphoma With T(9 22)(Q34.1 Q11.2) Bcr-Abl1 B Lymphoblastic Leukemia/Lymphoma With T(9 22)(Q34.1 Q11.2) Bcr-Abl1
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Lymphopenia	Lymphocytopenia
Adult Acute Lymphocytic Leukemia	Adult Acute Lymphoid Leukemia Adult All
Childhood Acute Lymphocytic Leukemia	Childhood Acute Lymphoblastic Leukemia Childhood All Pediatric Acute Lymphoblastic Leukemia Lymphoblastic Leukemia Acute Childhood
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Joubert Syndrome 6	JBTS6 Joubert Syndrome, Type 6
Trichorhinophalangeal Syndrome, Type I	Trichorhinophalangeal Dysplasia Type I TRPS1 Trichorhinophalangeal Syndrome Type I Trps I Trichorhinophalangeal Syndrome Type 1 Type I Trichorhinophalangeal Syndrome Giedion Syndrome Trp Syndrome Tricho-Rhino-Phalangeal Syndrome 1 Trichorhinophalangeal Syndrome, Type Iii
B-Lymphoblastic Leukemia/Lymphoma With Etv6-Runx1	B-All With Etv6-Runx1 B-Lymphoblastic Leukemia/Lymphoma With T(12 21)(P13.2 Q22.1) Etv6-Runx1 B Lymphoblastic Leukemia/Lymphoma With T(12 21)(P13.2 Q22.1) Etv6-Runx1
Childhood B-Cell Acute Lymphoblastic Leukemia	B-Cell Childhood Acute Lymphoblastic Leukemia
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Childhood Leukemia
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
Dendritic Cell Deficiency
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Agammaglobulinemia 4, Autosomal Recessive	Agammaglobulinemia 4 AGM4 Agammaglobulinemia, Autosomal Recessive, Due To Blnk Defect B Cell Linker Protein Deficiency B-Cell Linker Protein Deficiency Blnk Deficiency Agammaglobulinemia Autosomal Recessive Due To Blnk Defect Agammaglobulinemia, Type 4, Autosomal Recessive
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Trichorhinophalangeal Syndrome, Type Ii	Langer-Giedion Syndrome Lgs Trichorhinophalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome Type 2 TRPS2 Monosomy 8q24.1 Chromosome 8q24.1 Deletion Syndrome Deletion 8q24.1 Giedion-Langer Syndrome Trichorhinophalangeal Dysplasia Type Ii Langer Giedion Syndrome Trps 2 Tricho-Rhino-Phalangeal Syndrome Type Ii Trichorhinophalangeal Syndrome With Exostosis Trps Ii Tricho-Rhino-Phalangeal Syndrome 2 8q24.1 Microdeletion Syndrome 8q24.1 Deletion Syndrome
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Chromosomal Duplication Syndrome
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10984	Pomalidomide	Degrader	99.96%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-144841	Cemsidomide	Degrader	99.54%	Phase 2
HY-145776	ALV1	Inhibitor	98.62%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W1135319	SB-405483		99.33%	Unkown
HY-156641	Sontigidomide	Degrader	98.62%	Unkown
HY-168615	MGD-28	Degrader	99.73%	Unkown
HY-168614	MGD-4	Degrader	/	Unkown
HY-174458	MD-4251		/	Unkown
HY-182797	NHWL071065	Degrader	/	Unkown
HY-175600	MI-2-80	Degrader	/	Unkown
HY-175602	TM-04-064-02	Degrader	/	Unkown
HY-175040	PROTAC FLT-3 degrader 5	Degrader	/	Unkown
HY-181651	SZU305	Inhibitor	/	Unkown
HY-179075	PROTAC BCL6/IKZF1/3 Degrader-1	Degrader	/	Unkown
HY-179077	PROTAC BTK/IKZF1/3 Degrader-1	Degrader	/	Unkown
HY-179076	BTK/IKZF1/3 ligand 1	Ligand	/	Unkown
HY-175502	MGD-22	Degrader	/	Unkown
HY-180836	DIX-01	Degrader	/	Unkown
HY-160531	IKZF1-degrader-1	Degrader	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IKZF1	RGD	RGD:1562979
Macaca mulatta	IKZF1	VGNC	VGNC:73585
Canis familiaris	IKZF1	VGNC	VGNC:41923
Bos taurus	IKZF1	VGNC	VGNC:30103
Mus musculus	IKZF1	MGD	MGI:1342540
Felis catus	IKZF1	VGNC	VGNC:102613
Others	IKZF1	NCBI