BSJ-02-162
Based on 1 Customer Validation
BSJ-02-162 (CDK4/6-IN-11) is a CDK4/CDK6 and IKZF1/IKZF3 degrader, with DC50 values of 32 nM and 6.1 nM against CDK4 and CDK6, respectively; its IC50 ranges from 1 to 50 nM. BSJ-02-162 induces G1-phase cell cycle arrest, reduces phosphorylated retinoblastoma protein levels, and exerts antiproliferative activity in mantle cell lymphoma cells. BSJ-02-162 is applicable to research related to mantle cell lymphoma.
(Pink: CDK4 and CDK6 ligand (HY-50767); Blue: Cereblon ligand (HY-131717); Black: linker (HY-W007803)).
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 2139329-47-6
- Formula: C43H49N11O7
- Molecular Weight:831.92
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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CDK4 32 nM (DC50) |
CDK6 6.1 nM (DC50) |
IKZF1 |
IKZF3 |
BSJ-02-162 (1 μM; 4 h) induces CRBN-dependent degradation of CDK4, CDK6, IKZF1 and IKZF3 proteins in Jurkat cells[2].
BSJ-02-162 (0.1-1 μM; 24 h) induces CRBN-dependent G1 cell cycle arrest in wild-type Jurkat and MCL cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat T cells
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Concentration:1 μM
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Incubation Time:4 h
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Result:Induced degradation of both CDK4 and CDK6 proteins, as well as degradation of IKZF1 and IKZF3 proteins.
Showed no effect on CDK4/6 or IKZF1/3 abundance in CRBN-knockout Jurkat cells, confirming degradation was dependent on functional CRBN.
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Cell Line:Jurkat and MCL cells
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Concentration:0.1 and 1 μM
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Incubation Time:24 h
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Result:Induced profound G1 cell cycle arrest.
Chemical Information
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CAS No. 2139329-47-6
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Appearance Solid
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Molecular Weight 831.92
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Formula C43H49N11O7
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Color Light yellow to yellow
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SMILES
O=C(NCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)CNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O
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Synonyms
CDK4/6-IN-11
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (30.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2020 mL | 6.0102 mL | 12.0204 mL | 30.0510 mL |
| 5 mM | 0.2404 mL | 1.2020 mL | 2.4041 mL | 6.0102 mL | |
| 10 mM | 0.1202 mL | 0.6010 mL | 1.2020 mL | 3.0051 mL | |
| 15 mM | 0.0801 mL | 0.4007 mL | 0.8014 mL | 2.0034 mL | |
| 20 mM | 0.0601 mL | 0.3005 mL | 0.6010 mL | 1.5025 mL | |
| 25 mM | 0.0481 mL | 0.2404 mL | 0.4808 mL | 1.2020 mL | |
| 30 mM | 0.0401 mL | 0.2003 mL | 0.4007 mL | 1.0017 mL |
BSJ-02-162 Related Classifications
HY-144995 Related Classifications
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