CKS1B - CDC28 protein kinase regulatory subunit 1B Gene

Also Known as CKS1; ckshs1; PNAS-16; PNAS-18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1163

About CKS1B

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,974,681-154,979,251 (from NCBI)

This gene has 7 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 29.0), fat (RPKM 22.7) and 24 other tissues.

Summary

CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]

CKS1B Products (1)

mRNA Protein Name
NM_001826.3 NP_001817.1 cyclin-dependent kinases regulatory subunit 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
2227411 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CKS1B Protein Structure

CKS

CKS: Cyclin-dependent kinase regulatory subunit (5 - 73)

  • 0
  • 79 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinases regulatory subunit 1

  • CDC2-associated protein CKS1

CKS1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CKS1B P61024 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
CKS1B P61024 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 CDX4 Homo sapiens O14627
Y2H Array
25416956
Intra
CKS1B P61024 DCDC2 Homo sapiens Q9UHG0
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 DCDC2 Homo sapiens Q9UHG0
Validated Y2H
32296183
Intra
CKS1B P61024 DCDC2 Homo sapiens Q9UHG0
Y2H Array
32296183
Intra
CKS1B P61024 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra
CKS1B P61024 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra
CKS1B P61024 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
CKS1B P61024 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
Intra
CKS1B P61024 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra
CKS1B P61024 IKZF1 Homo sapiens Q13422-7
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 IKZF1 Homo sapiens Q13422-7
Validated Y2H
32296183
Intra
CKS1B P61024 IKZF1 Homo sapiens Q13422-7
Y2H Array
32296183
Intra
CKS1B P61024 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
Intra
CKS1B P61024 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
32296183
Intra
CKS1B P61024 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
Intra
CKS1B P61024 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra
CKS1B P61024 WASF3 Homo sapiens Q9UPY6-2
Validated Y2H
32296183
Intra
CKS1B P61024 WASF3 Homo sapiens Q9UPY6-2
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 WASF3 Homo sapiens Q9UPY6-2
Y2H Array
32296183
Intra
CKS1B P61024 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
Intra
CKS1B P61024 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra
CKS1B P61024 SPDYE4 Homo sapiens A6NLX3
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 SPDYE4 Homo sapiens A6NLX3
Y2H Array
32296183
Intra
CKS1B P61024 CT45A1 Homo sapiens Q5HYN5
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 CT45A1 Homo sapiens Q5HYN5
Y2H Array
32296183
Intra
CKS1B P61024 CT45A1 Homo sapiens Q5HYN5
Validated Y2H
32296183
Intra
CKS1B P61024 LZTS1 Homo sapiens Q9Y250
Validated Y2H
32296183
Intra
CKS1B P61024 LZTS1 Homo sapiens Q9Y250
Y2H Array
32296183
Intra
CKS1B P61024 LZTS1 Homo sapiens Q9Y250
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 CDK3 Homo sapiens Q00526
Anti Tag CoIP
33961781
Intra
CKS1B P61024 CDK3 Homo sapiens Q00526
Anti Tag CoIP
28514442
Intra
CKS1B P61024 CDK3 Homo sapiens Q00526
Validated Y2H
32296183
Intra
CKS1B P61024 TRIM49C Homo sapiens P0CI26
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 TRIM49C Homo sapiens P0CI26
Y2H Array
32296183
Intra
CKS1B P61024 SNRNP35 Homo sapiens Q16560-2
Validated Y2H
32296183
Intra
CKS1B P61024 SNRNP35 Homo sapiens Q16560-2
Y2H Array
32296183
Intra
CKS1B P61024 SNRNP35 Homo sapiens Q16560-2
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
CKS1B P61024 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 ROPN1 Homo sapiens Q9HAT0
Validated Y2H
32296183
Intra
CKS1B P61024 ROPN1 Homo sapiens Q9HAT0
Y2H Array
32296183
Intra
CKS1B P61024 ROPN1 Homo sapiens Q9HAT0
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
CKS1B P61024 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
CKS1B P61024 MIPOL1 Homo sapiens Q8TD10
Validated Y2H
25416956
Intra
CKS1B P61024 MIPOL1 Homo sapiens Q8TD10
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 MIPOL1 Homo sapiens Q8TD10
Y2H Array
25416956
Intra
CKS1B P61024 TRIM14 Homo sapiens Q14142
Validated Y2H
32296183
Intra
CKS1B P61024 TRIM14 Homo sapiens Q14142
Y2H Array
32296183
Intra
CKS1B P61024 TRIM14 Homo sapiens Q14142
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 SERTAD2 Homo sapiens Q14140
Validated Y2H
32296183
Intra
CKS1B P61024 SERTAD2 Homo sapiens Q14140
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 SERTAD2 Homo sapiens Q14140
Y2H Array
32296183
Intra
CKS1B P61024 MEOX1 Homo sapiens P50221
Y2H Array
25416956
Intra
CKS1B P61024 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra
CKS1B P61024 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 PAX5 Homo sapiens Q02548
Y2H Array
32296183
Intra
CKS1B P61024 PAX5 Homo sapiens Q02548
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 PAX5 Homo sapiens Q02548
Validated Y2H
32296183
Intra
CKS1B P61024 CDK2 Homo sapiens P24941
BRET
37398436
Intra
CKS1B P61024 CDK2 Homo sapiens P24941
Anti Tag CoIP
33961781
Intra
CKS1B P61024 CDK2 Homo sapiens P24941
Anti Tag CoIP
28514442
Intra
CKS1B P61024 CCNC Homo sapiens P24863
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 CCNC Homo sapiens P24863
Y2H Array
32296183
Intra
CKS1B P61024 ZBTB9 Homo sapiens Q96C00
Validated Y2H
32296183
Intra
CKS1B P61024 ZBTB9 Homo sapiens Q96C00
Y2H Array
32296183
Intra
CKS1B P61024 ZBTB9 Homo sapiens Q96C00
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 MED12L Homo sapiens Q86YW9
Y2H Array
32296183
Intra
CKS1B P61024 MED12L Homo sapiens Q86YW9
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 MED12L Homo sapiens Q86YW9
Validated Y2H
32296183
Intra
CKS1B P61024 CDK1 Homo sapiens P06493
Anti Tag CoIP
33961781
Intra
CKS1B P61024 CDK1 Homo sapiens P06493
Anti Tag CoIP
28514442
Intra
CKS1B P61024 SKP2 Homo sapiens Q13309
Anti Tag CoIP
33961781
Intra
CKS1B P61024 SKP2 Homo sapiens Q13309
X-Ray Diffraction
16209941
Intra
CKS1B P61024 SKP2 Homo sapiens Q13309
Anti Tag CoIP
28514442
Intra
CKS1B P61024 SKP2 Homo sapiens Q13309
Pull Down
12813041
Intra
CKS1B P61024 SKP2 Homo sapiens Q13309
ITC
16209941
Intra
CKS1B P61024 XIAP Homo sapiens P98170
Validated Y2H
32296183
Intra
CKS1B P61024 XIAP Homo sapiens P98170
Y2H Array
32296183
Intra
CKS1B P61024 XIAP Homo sapiens P98170
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 XIAP Homo sapiens P98170
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 XIAP Homo sapiens P98170
Y2H Array
31515488
Intra
CKS1B P61024 TCF4 Homo sapiens P15884
Validated Y2H
25416956
Intra
CKS1B P61024 TCF4 Homo sapiens P15884
Y2H Array
25416956
Intra
CKS1B P61024 TRIM49 Homo sapiens P0CI25
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 TRIM49 Homo sapiens P0CI25
Y2H Array
32296183
Intra
CKS1B P61024 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
CKS1B P61024 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
CKS1B P61024 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
CKS1B P61024 TRIM27 Homo sapiens P14373
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
CKS1B P61024 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
CKS1B P61024 SEPTIN3 Homo sapiens Q9UH03
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 SEPTIN3 Homo sapiens Q9UH03
Validated Y2H
25416956
Intra
CKS1B P61024 SEPTIN3 Homo sapiens Q9UH03
Validated Y2H
32296183
Intra
CKS1B P61024 SEPTIN3 Homo sapiens Q9UH03
Y2H Array
32296183
Intra
CKS1B P61024 CBY2 Homo sapiens Q8NA61
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 CCDC120 Homo sapiens Q96HB5
Validated Y2H
32296183
Intra
CKS1B P61024 CCDC120 Homo sapiens Q96HB5
Y2H Array
32296183
Intra
CKS1B P61024 CCDC120 Homo sapiens Q96HB5
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 IKZF1 Homo sapiens Q13422
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
CKS1B P61024 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
CKS1B P61024 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 PAX6 Homo sapiens P26367
Y2H Array
32296183
Intra
CKS1B P61024 SERTAD1 Homo sapiens Q9UHV2
Y2H Array
32296183
Intra
CKS1B P61024 SERTAD1 Homo sapiens Q9UHV2
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 NR5A1 Homo sapiens Q13285
Y2H Array
32296183
Intra
CKS1B P61024 NR5A1 Homo sapiens Q13285
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 NR5A1 Homo sapiens Q13285
Validated Y2H
32296183
Intra
CKS1B P61024 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
25416956
Intra
CKS1B P61024 ARID5A Homo sapiens Q03989
Validated Y2H
32296183
Intra
CKS1B P61024 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
Intra
CKS1B P61024 ARID5A Homo sapiens Q03989
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Clear Cell Adenofibroma

  • Cystadenofibroma
Monoclonal Gammopathy Of Uncertain Significance

  • Monoclonal Gammopathy Of Undetermined Significance

  • Mgus

  • Mgus - [Monoclonal Gammopathy Of Undetermined Significance]

  • Monoclonal Gammopathy Nos

  • Iga Gammopathy

  • Monoclonal Gammoglobulinopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02742 CKS1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20379 Cks1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26889 Cks1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CKS1B RGD RGD:1561797
Bos taurus CKS1B VGNC VGNC:27387
Mus musculus CKS1B MGD MGI:1889208
Macaca mulatta CKS1B VGNC VGNC:106341
Others CKS1B NCBI