CKS1B - CDC28 protein kinase regulatory subunit 1B Gene

Homo sapiens

Also known as CKS1; ckshs1; PNAS-16; PNAS-18

Gene ID: 1163 | Gene type: protein coding

About CKS1B

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,974,681-154,979,251 (from NCBI)

This gene has 7 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 29.0), fat (RPKM 22.7) and 24 other tissues.

Summary

CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein. At least two transcript variants have been identified for this gene, and it appears that only one of them encodes a protein. [provided by RefSeq, Sep 2008]

CKS1B Products(1)

mRNA	Protein	Name
NM_001826.3	NP_001817.1	cyclin-dependent kinases regulatory subunit 1

CKS1B Protein Structure

CKS

0
79 a.a.

Protein Preferred Names

Protein Names

cyclin-dependent kinases regulatory subunit 1

CDC2-associated protein CKS1

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Clear Cell Adenofibroma

Cystadenofibroma

Monoclonal Gammopathy Of Uncertain Significance

Monoclonal Gammopathy Of Undetermined Significance	Mgus
Mgus - [Monoclonal Gammopathy Of Undetermined Significance]	Monoclonal Gammopathy Nos
Iga Gammopathy	Monoclonal Gammoglobulinopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02742	CKS1B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CKS1B	RGD	RGD:1561797
Bos taurus	CKS1B	VGNC	VGNC:27387
Mus musculus	CKS1B	MGD	MGI:1889208
Macaca mulatta	CKS1B	VGNC	VGNC:106341
Others	CKS1B	NCBI

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