TRIM14 - tripartite motif containing 14 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9830

About TRIM14

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:98,035,797-98,119,222 (from NCBI)

Ubiquitous expression in colon (RPKM 8.0), small intestine (RPKM 7.7) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

TRIM14 Products (2)

mRNA Protein Name
NM_014788.4 NP_055603.2 tripartite motif-containing protein 14
NM_033219.3 NP_150088.1 tripartite motif-containing protein 14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
35145029 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
23077300 GOA
Biological Process GO Annotation Evidence References Source
involved in inflammatory response IDA
IDA: Inferred from direct assay
35145029 GOA
involved in innate immune response IDA
IDA: Inferred from direct assay
18248090 GOA
involved in negative regulation of viral transcription IDA
IDA: Inferred from direct assay
18248090 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
23077300 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
23077300 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
35145029 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11331580 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIM14 Protein Structure

zf-B_box

zf-B_box: B-box zinc finger (22 - 58)

PRY

PRY: SPRY-associated domain (270 - 317)

SPRY

SPRY: SPRY domain (320 - 434)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 442 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 14

  • tripartite motif protein TRIM14

TRIM14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRIM14 Q14142 ZGPAT Homo sapiens Q8N5A5-2
Validated Y2H
32296183
Intra
TRIM14 Q14142 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra
TRIM14 Q14142 CCDC6 Homo sapiens Q16204
Validated Y2H
32296183
Intra
TRIM14 Q14142 CCDC57 Homo sapiens Q2TAC2-2
Validated Y2H
32296183
Intra
TRIM14 Q14142 PRDM6 Homo sapiens Q9NQX0
Y2H Prey Pooling
32296183
Intra
TRIM14 Q14142 PRDM6 Homo sapiens Q9NQX0
Validated Y2H
32296183
Intra
TRIM14 Q14142 PRDM6 Homo sapiens Q9NQX0
Y2H Array
32296183
Intra
TRIM14 Q14142 CARD9 Homo sapiens Q9H257-2
Validated Y2H
32296183
Intra
TRIM14 Q14142 CCDC125 Homo sapiens Q86Z20
Y2H Prey Pooling
32296183
Intra
TRIM14 Q14142 CCDC125 Homo sapiens Q86Z20
Validated Y2H
32296183
Intra
TRIM14 Q14142 CCDC125 Homo sapiens Q86Z20
Y2H Array
32296183
Intra
TRIM14 Q14142 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
TRIM14 Q14142 PRPF31 Homo sapiens Q8WWY3
Validated Y2H
32296183
Intra
TRIM14 Q14142 SLF2 Homo sapiens Q8IX21
Validated Y2H
32296183
Intra
TRIM14 Q14142 PTPN21 Homo sapiens Q16825
Validated Y2H
32296183
Intra
TRIM14 Q14142 VIM Homo sapiens P08670
Y2H Array
32296183
Intra
TRIM14 Q14142 VIM Homo sapiens P08670
Y2H Prey Pooling
32296183
Intra
TRIM14 Q14142 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
TRIM14 Q14142 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
TRIM14 Q14142 HEXIM2 Homo sapiens Q96MH2
Validated Y2H
32296183
Intra
TRIM14 Q14142 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
TRIM14 Q14142 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
TRIM14 Q14142 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
TRIM14 Q14142 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
TRIM14 Q14142 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Intra
TRIM14 Q14142 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TRIM14 Q14142 EXOC8 Homo sapiens Q8IYI6
Validated Y2H
32296183
Intra
TRIM14 Q14142 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Intra
TRIM14 Q14142 FAM50B Homo sapiens Q9Y247
Validated Y2H
32296183
Intra
TRIM14 Q14142 TSGA10 Homo sapiens Q9BZW7
Validated Y2H
32296183
Intra
TRIM14 Q14142 IHO1 Homo sapiens Q8IYA8
Y2H Prey Pooling
32296183
Intra
TRIM14 Q14142 IHO1 Homo sapiens Q8IYA8
Validated Y2H
32296183
Intra
TRIM14 Q14142 IHO1 Homo sapiens Q8IYA8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spondyloepimetaphyseal Dysplasia, Genevieve Type

  • SEMDG

  • Semd, Genevieve Type

  • Nans Deficiency

  • Semd Genevieve Type

  • Spondyloepimetaphyseal Dysplasia, Camera-Genevieve Type

  • Spondyloepimetaphyseal Dysplasia, Genevieve-Type

  • Spondyloepimetaphyseal Dysplasia Genevieve Type

  • Dysplasia, Spondyloepimetaphyseal, Camera-Genevieve Type
Tongue Disease

  • Abnormality Of The Tongue

  • Tongue Diseases

  • Tongue Disorders

  • Disorder Of Tongue

  • Glossopathy

  • Unspecified Condition Of The Tongue
Tongue Squamous Cell Carcinoma

  • Squamous Cell Carcinoma Of Tongue
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15022 TRIM14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20197 Trim14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26702 Trim14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRIM14 MGD MGI:1921985
Canis familiaris TRIM14 VGNC VGNC:47806
Bos taurus TRIM14 VGNC VGNC:36315
Macaca mulatta TRIM14 VGNC VGNC:79025
Rattus norvegicus TRIM14 RGD RGD:1311514
Felis catus TRIM14 VGNC VGNC:103001
Others TRIM14 NCBI