CCDC6 - coiled-coil domain containing 6 Gene

Homo sapiens

Also known as H4; PTC; TPC; PTC1; TST1; D10S170

Gene ID: 8030 | Gene type: protein coding

About CCDC6

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:59,788,747-59,906,556 (from NCBI)

This gene has 3 transcripts (splice variants), 223 orthologues and is associated with 78 phenotypes. Ubiquitous expression in esophagus (RPKM 21.3), brain (RPKM 15.5) and 25 other tissues.

Summary

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the RET proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

CCDC6 Products(1)

mRNA	Protein	Name
NM_005436.5	NP_005427.2	coiled-coil domain-containing protein 6

CCDC6 Protein Structure

DUF2046

0
100
200
300
400
474 a.a.

Protein Preferred Names

Protein Names

coiled-coil domain-containing protein 6

papillary thyroid carcinoma-encoded protein

Related Diseases

Diseases

Alias

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Papillary Carcinoma

Carcinoma, Papillary

Carcinoma Papillary

Thyroid Gland Cancer

Thyroid Gland Carcinoma	Malignant Neoplasm Of Thyroid Gland
Malignant Tumour Of Thyroid Gland	Thyroid Neoplasm
Thyroid Neoplasms	Neoplasm Of Thyroid Gland
Thyroid Gland Neoplasm	Head And Neck Cancer, Thyroid
Neoplasm Of The Thyroid Gland	Cancer Of The Thyroid
Primary Malignant Neoplasm Of Thyroglossal Duct	Malignant Neoplasm Of Thyroglossal Duct
Primary Malignant Neoplasm Of Thyroid Gland	Thyroglossal Duct Cancer
Toxic Goitre Malignant Tumour	Cancerous Goitre

Internal Hordeolum

Multiple Endocrine Neoplasia, Type Iib

Multiple Endocrine Neoplasia Type 2b	MEN2B
Wagenmann-Froboese Syndrome	Multiple Endocrine Neoplasia Iib
Mucosal Neuroma Syndrome	Multiple Endocrine Neoplasia, Type 3
Multiple Endocrine Neoplasia, Type 2b	Men Iib
Neuromata, Mucosal, With Endocrine Tumors	Multiple Endocrine Neoplasia, Type Iii, Formerly
Men3, Formerly	Men Type Iib
Men 2b	Multiple Endocrine Neoplasia Type 3
Multiple Neoplasia 2b	Neoplasia, Endocrine, Multiple, Type Iib

Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma	Medullary Carcinoma Of The Thyroid Gland
Ultimobranchial Thyroid Tumor	Ultimobranchial Thyroid Tumour
Thyroid Cancer, Medullary

Commensal Bacterial Infectious Disease

Thyroid Gland Follicular Carcinoma

Follicular Thyroid Carcinoma	Follicular Adenocarcinoma
Follicular Adenocarcinoma, Well Differentiated	Follicular Carcinoma
Thyroid Adenocarcinoma	Adenocarcinoma, Follicular

Thyroid Gland Anaplastic Carcinoma

Anaplastic Thyroid Carcinoma	Anaplastic Thyroid Cancer
Thyroid Cancer, Anaplastic	Thyroid Carcinoma, Anaplastic
Thyroid Carcinoma Anaplastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112301	Pralsetinib	Inhibitor	99.98%	Yes

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133551	WF-47-JS03	Inhibitor	99.63%	Unkown
HY-144131	RET-IN-11		/	Unkown
HY-146710	RET-IN-16	Inhibitor	/	Unkown
HY-153676	RET-IN-23	Inhibitor	/	Unkown
HY-RS02051	CCDC6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CCDC6	MGD	MGI:1923801
Canis familiaris	CCDC6	VGNC	VGNC:38845
Rattus norvegicus	CCDC6	RGD	RGD:1587433
Bos taurus	CCDC6	VGNC	VGNC:26904
Macaca mulatta	CCDC6	VGNC	VGNC:70825

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