CCDC6 - coiled-coil domain containing 6 Gene

Also Known as H4; PTC; TPC; PTC1; TST1; D10S170

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8030

About CCDC6

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:59,788,747-59,906,556 (from NCBI)

This gene has 3 transcripts (splice variants), 223 orthologues and is associated with 78 phenotypes. Ubiquitous expression in esophagus (RPKM 21.3), brain (RPKM 15.5) and 25 other tissues.

Summary

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the RET proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010]

CCDC6 Products (1)

mRNA Protein Name
NM_005436.5 NP_005427.2 coiled-coil domain-containing protein 6

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
23108047 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCDC6 Protein Structure

DUF2046

DUF2046: Uncharacterized conserved protein H4 (DUF2046) (2 - 341)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 474 a.a.
Protein Preferred Names Protein Names

coiled-coil domain-containing protein 6

  • papillary thyroid carcinoma-encoded protein

CCDC6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CCDC6 Q16204 LUZP4 Homo sapiens Q9P127
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 LUZP4 Homo sapiens Q9P127
Validated Y2H
32296183
Intra
CCDC6 Q16204 LUZP4 Homo sapiens Q9P127
Y2H Array
32296183
Intra
CCDC6 Q16204 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra
CCDC6 Q16204 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 ZNF774 Homo sapiens Q6NX45
Validated Y2H
32296183
Intra
CCDC6 Q16204 PPP4C Homo sapiens P60510
Anti Tag CoIP
33961781
Intra
CCDC6 Q16204 PPP4C Homo sapiens P60510
Anti Tag CoIP
28514442
Intra
CCDC6 Q16204 GAS8 Homo sapiens O95995
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 GAS8 Homo sapiens O95995
Y2H Array
32296183
Intra
CCDC6 Q16204 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
CCDC6 Q16204 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
CCDC6 Q16204 CYTH4 Homo sapiens Q9UIA0
Y2H Array
32296183
Intra
CCDC6 Q16204 CYTH4 Homo sapiens Q9UIA0
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 CYTH4 Homo sapiens Q9UIA0
Validated Y2H
32296183
Intra
CCDC6 Q16204 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
CCDC6 Q16204 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
CCDC6 Q16204 SNAPC1 Homo sapiens Q16533
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 SNAPC1 Homo sapiens Q16533
Validated Y2H
32296183
Intra
CCDC6 Q16204 SNAPC1 Homo sapiens Q16533
Y2H Array
32296183
Intra
CCDC6 Q16204 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra
CCDC6 Q16204 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
Intra
CCDC6 Q16204 MAPK7 Homo sapiens Q13164
Y2H Array
32296183
Intra
CCDC6 Q16204 MAPK7 Homo sapiens Q13164
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
CCDC6 Q16204 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
CCDC6 Q16204 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 CENPQ Homo sapiens Q7L2Z9
Validated Y2H
32296183
Intra
CCDC6 Q16204 CENPQ Homo sapiens Q7L2Z9
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 CENPQ Homo sapiens Q7L2Z9
Y2H Array
32296183
Intra
CCDC6 Q16204 TRIM14 Homo sapiens Q14142
Y2H Array
32296183
Intra
CCDC6 Q16204 TRIM14 Homo sapiens Q14142
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 FBXW7 Homo sapiens Q969H0
Anti Tag CoIP
23108047
Intra
CCDC6 Q16204 FBXW7 Homo sapiens Q969H0
Anti Bait CoIP
23108047
Intra
CCDC6 Q16204 ZNF620 Homo sapiens Q6ZNG0
Validated Y2H
32296183
Intra
CCDC6 Q16204 ZNF620 Homo sapiens Q6ZNG0
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 ZNF620 Homo sapiens Q6ZNG0
Y2H Array
32296183
Intra
CCDC6 Q16204 ATF5 Homo sapiens Q9Y2D1
Y2H Array
32296183
Intra
CCDC6 Q16204 ATF5 Homo sapiens Q9Y2D1
Validated Y2H
32296183
Intra
CCDC6 Q16204 ATF5 Homo sapiens Q9Y2D1
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 ANKRD23 Homo sapiens Q86SG2
Validated Y2H
32296183
Intra
CCDC6 Q16204 ANKRD23 Homo sapiens Q86SG2
Y2H Array
32296183
Intra
CCDC6 Q16204 ANKRD23 Homo sapiens Q86SG2
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 ZNF835 Homo sapiens Q9Y2P0
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 ZNF835 Homo sapiens Q9Y2P0
Validated Y2H
32296183
Intra
CCDC6 Q16204 ZNF835 Homo sapiens Q9Y2P0
Y2H Array
32296183
Intra
CCDC6 Q16204 PIN1 Homo sapiens Q13526
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 PIN1 Homo sapiens Q13526
Y2H Array
32296183
Intra
CCDC6 Q16204 LRSAM1 Homo sapiens Q6UWE0
Validated Y2H
32296183
Intra
CCDC6 Q16204 HMG20A Homo sapiens Q9NP66
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 HMG20A Homo sapiens Q9NP66
Validated Y2H
32296183
Intra
CCDC6 Q16204 HMG20A Homo sapiens Q9NP66
Y2H Array
32296183
Intra
CCDC6 Q16204 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
CCDC6 Q16204 PAX6 Homo sapiens P26367
Y2H Prey Pooling
32296183
Intra
CCDC6 Q16204 PAX6 Homo sapiens P26367
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

CCDC6 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89680 CCDC6 Antibody (YA9024) WB, IP, ELISA human

Related Diseases

Diseases Alias
Differentiated Thyroid Carcinoma

  • Papillary Or Follicular Thyroid Carcinoma

  • Well-Differentiated Thyroid Carcinoma

  • Differentiated Thyroid Gland Carcinoma
Papillary Carcinoma

  • Carcinoma, Papillary

  • Carcinoma Papillary
Thyroid Gland Cancer

  • Thyroid Gland Carcinoma

  • Malignant Neoplasm Of Thyroid Gland

  • Malignant Tumour Of Thyroid Gland

  • Thyroid Neoplasm

  • Thyroid Neoplasms

  • Neoplasm Of Thyroid Gland

  • Thyroid Gland Neoplasm

  • Head And Neck Cancer, Thyroid

  • Neoplasm Of The Thyroid Gland

  • Cancer Of The Thyroid

  • Primary Malignant Neoplasm Of Thyroglossal Duct

  • Malignant Neoplasm Of Thyroglossal Duct

  • Primary Malignant Neoplasm Of Thyroid Gland

  • Thyroglossal Duct Cancer

  • Toxic Goitre Malignant Tumour

  • Cancerous Goitre
Internal Hordeolum
Multiple Endocrine Neoplasia, Type Iib

  • Multiple Endocrine Neoplasia Type 2b

  • MEN2B

  • Wagenmann-Froboese Syndrome

  • Multiple Endocrine Neoplasia Iib

  • Mucosal Neuroma Syndrome

  • Multiple Endocrine Neoplasia, Type 3

  • Multiple Endocrine Neoplasia, Type 2b

  • Men Iib

  • Neuromata, Mucosal, With Endocrine Tumors

  • Multiple Endocrine Neoplasia, Type Iii, Formerly

  • Men3, Formerly

  • Men Type Iib

  • Men 2b

  • Multiple Endocrine Neoplasia Type 3

  • Multiple Neoplasia 2b

  • Neoplasia, Endocrine, Multiple, Type Iib
Thyroid Gland Medullary Carcinoma

  • Medullary Thyroid Carcinoma

  • Medullary Carcinoma Of The Thyroid Gland

  • Ultimobranchial Thyroid Tumor

  • Ultimobranchial Thyroid Tumour

  • Thyroid Cancer, Medullary
Commensal Bacterial Infectious Disease
Thyroid Gland Follicular Carcinoma

  • Follicular Thyroid Carcinoma

  • Follicular Adenocarcinoma

  • Follicular Adenocarcinoma, Well Differentiated

  • Follicular Carcinoma

  • Thyroid Adenocarcinoma

  • Adenocarcinoma, Follicular
Thyroid Gland Anaplastic Carcinoma

  • Anaplastic Thyroid Carcinoma

  • Anaplastic Thyroid Cancer

  • Thyroid Cancer, Anaplastic

  • Thyroid Carcinoma, Anaplastic

  • Thyroid Carcinoma Anaplastic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112301 Pralsetinib Inhibitor 99.98% Yes

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133551 WF-47-JS03 Inhibitor 99.63% Unkown
HY-178061 APS03118 Inhibitor / Unkown
HY-144131 RET-IN-11 / Unkown
HY-146710 RET-IN-16 Inhibitor / Unkown
HY-153676 RET-IN-23 Inhibitor / Unkown
HY-170809 RET-IN-29 Inhibitor / Unkown
HY-170926 CQ1373 / Unkown
HY-178964 PROTAC RET Degrader 1 Degrader / Unkown
HY-181895 PROTAC HyTTD Degrader-1 Degrader / Unkown
HY-RS02051 CCDC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20872 Ccdc6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27389 Ccdc6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CCDC6 MGD MGI:1923801
Canis familiaris CCDC6 VGNC VGNC:38845
Rattus norvegicus CCDC6 RGD RGD:1587433
Bos taurus CCDC6 VGNC VGNC:26904
Macaca mulatta CCDC6 VGNC VGNC:70825
Others CCDC6 NCBI