CENPQ - centromere protein Q Gene

Also Known as CENP-Q; C6orf139

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55166

About CENPQ

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:49,463,370-49,493,107 (from NCBI)

This gene has 1 transcript (splice variant) and 170 orthologues. Ubiquitous expression in testis (RPKM 3.5), brain (RPKM 3.4) and 25 other tissues.

Summary

CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

CENPQ Products (1)

mRNA Protein Name
NM_018132.4 NP_060602.2 centromere protein Q

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26496610 GOA
Biological Process GO Annotation Evidence References Source
involved in metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
25395579 GOA
involved in positive regulation of protein localization to kinetochore IMP
IMP: Inferred from mutant phenotype
25395579 GOA
Cellular Component GO Annotation Evidence References Source
part of inner kinetochore IPI
IPI: Inferred from physical interaction
36085283 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPQ Protein Structure

CENP-Q

CENP-Q: CENP-Q, a CENPA-CAD centromere complex subunit (116 - 266)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

centromere protein Q

CENPQ Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CENPQ Q7L2Z9 CCDC6 Homo sapiens Q16204
Anti Tag CoIP
33961781
Intra
CENPQ Q7L2Z9 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
CENPQ Q7L2Z9 ATF2 Homo sapiens P15336
Anti Tag CoIP
33961781
Intra
CENPQ Q7L2Z9 ATF2 Homo sapiens P15336
Y2H Prey Pooling
32296183
Intra
CENPQ Q7L2Z9 EMILIN1 Homo sapiens Q9Y6C2-2
Validated Y2H
32296183
Intra
CENPQ Q7L2Z9 HDAC7 Homo sapiens Q8WUI4-6
Validated Y2H
32296183
Intra
CENPQ Q7L2Z9 SIKE1 Homo sapiens Q9BRV8
Validated Y2H
32296183
Intra
CENPQ Q7L2Z9 CENPU Homo sapiens Q71F23
Anti Tag CoIP
26496610
Intra
CENPQ Q7L2Z9 CENPU Homo sapiens Q71F23
Anti Tag CoIP
33961781
Intra
CENPQ Q7L2Z9 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
Intra
CENPQ Q7L2Z9 HOMER1 Homo sapiens Q86YM7
Anti Tag CoIP
33961781
Intra
CENPQ Q7L2Z9 HOMER1 Homo sapiens Q86YM7
MAPPIT
32296183
Intra
CENPQ Q7L2Z9 HOMER1 Homo sapiens Q86YM7
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Crest Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02489 CENPQ Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CENPQ VGNC VGNC:60760
Macaca mulatta CENPQ VGNC VGNC:81053
Bos taurus CENPQ VGNC VGNC:27184
Rattus norvegicus CENPQ RGD RGD:1359451
Mus musculus CENPQ MGD MGI:1933744
Canis familiaris CENPQ VGNC VGNC:39112
Others CENPQ NCBI