HOMER1 - homer scaffold protein 1 Gene

Also Known as HOMER; SYN47; Ves-1; HOMER1A; HOMER1B; HOMER1C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9456

About HOMER1

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:79,372,636-79,514,134 (from NCBI)

This gene has 5 transcripts (splice variants), 268 orthologues and 2 paralogues. Broad expression in brain (RPKM 8.6), thyroid (RPKM 5.8) and 14 other tissues.

Summary

This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]

HOMER1 Products (3)

mRNA	Protein	Name
NM_001277077.1	NP_001264006.1	homer protein homolog 1 isoform 2
NM_001277078.1	NP_001264007.1	homer protein homolog 1 isoform 3
NM_004272.5	NP_004263.1	homer protein homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	14505576	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in response to calcium ion	IDA IDA: Inferred from direct assay	14505576	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOMER1 Protein Structure

WH1

0
100
200
300
354 a.a.

Protein Preferred Names	Protein Names
homer protein homolog 1	homer homolog 1

HOMER1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HOMER1	Q86YM7	ABI1	Homo sapiens	Q8IZP0-5	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	ABI1	Homo sapiens	Q8IZP0-5	Y2H Array	32296183
Intra	HOMER1	Q86YM7	ABI1	Homo sapiens	Q8IZP0-5	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	SYCE2	Homo sapiens	Q6PIF2	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	SYCE2	Homo sapiens	Q6PIF2	Y2H Array	32296183
Intra	HOMER1	Q86YM7	SHANK2	Homo sapiens	Q9UPX8-4	Y2H Array	32296183
Intra	HOMER1	Q86YM7	SHANK2	Homo sapiens	Q9UPX8-4	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	SHANK2	Homo sapiens	Q9UPX8-4	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	INADL	Homo sapiens	A5PKX9	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	INADL	Homo sapiens	A5PKX9	Y2H Array	32296183
Intra	HOMER1	Q86YM7	AIMP1	Homo sapiens	Q12904-2	Y2H Array	32296183
Intra	HOMER1	Q86YM7	AIMP1	Homo sapiens	Q12904-2	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	ZMYM5	Homo sapiens	Q9UJ78-2	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	ZMYM5	Homo sapiens	Q9UJ78-2	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	ZMYM5	Homo sapiens	Q9UJ78-2	Y2H Array	32296183
Intra	HOMER1	Q86YM7	SARG	Homo sapiens	Q9BW04	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	SARG	Homo sapiens	Q9BW04	Y2H Array	32296183
Intra	HOMER1	Q86YM7	SARG	Homo sapiens	Q9BW04	Y2H Pooling	19447967
Intra	HOMER1	Q86YM7	SARG	Homo sapiens	Q9BW04	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	SARG	Homo sapiens	Q9BW04	Validated Y2H	25416956
Intra	HOMER1	Q86YM7	CENPQ	Homo sapiens	Q7L2Z9	Y2H Array	32296183
Intra	HOMER1	Q86YM7	CENPQ	Homo sapiens	Q7L2Z9	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	RASAL3	Homo sapiens	Q86YV0	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	RASAL3	Homo sapiens	Q86YV0	Y2H Array	32296183
Intra	HOMER1	Q86YM7	RASAL3	Homo sapiens	Q86YV0	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	HOMER1	Q86YM7	TRAF5	Homo sapiens	O00463	Anti Tag CoIP	28514442
Intra	HOMER1	Q86YM7	TRAF5	Homo sapiens	O00463	Anti Tag CoIP	33961781
Intra	HOMER1	Q86YM7	BRME1	Homo sapiens	Q0VDD7	Y2H Prey Pooling	25416956
Intra	HOMER1	Q86YM7	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Anti Tag CoIP	35271311
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	25416956
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Complementation	32296183
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	25416956
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	25416956
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	MAPPIT	25416956
Intra	HOMER1	Q86YM7	HOMER3	Homo sapiens	Q9NSC5	Anti Tag CoIP	25416956
Intra	HOMER1	Q86YM7	FAM9A	Homo sapiens	Q8IZU1	Y2H Prey Pooling	32296183
Intra	HOMER1	Q86YM7	FAM9A	Homo sapiens	Q8IZU1	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	FAM9A	Homo sapiens	Q8IZU1	Y2H Array	32296183
Intra	HOMER1	Q86YM7	RAD54L2	Homo sapiens	Q9Y4B4	Validated Y2H	32296183
Intra	HOMER1	Q86YM7	RAD54L2	Homo sapiens	Q9Y4B4	Y2H Array	32296183
Intra	HOMER1	Q86YM7	RAD54L2	Homo sapiens	Q9Y4B4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

HOMER1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83290	Homer1 Antibody (YA3035)	WB, IP	Mouse, Rat
HY-P83290A	Homer1 Antibody (YA3035)(PBS only)	WB, IP	Mouse, Rat
HY-P86909	Homer1 Antibody (YA6602)	WB, IHC-P, IHC-F	Mouse, Rat

Related Diseases

Diseases	Alias
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Deafness, Autosomal Dominant 68	DFNA68 Autosomal Dominant Nonsyndromic Deafness 68 Autosomal Dominant Deafness 68 Deafness, Autosomal Dominant, 68
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Ogden Syndrome	OGDNS N-Terminal Acetyltransferase Deficiency NATD N-Alpha-Acetyltransferase X-Linked Malformation And Infantile Lethality Syndrome Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Phelan-Mcdermid Syndrome	Chromosome 22q13.3 Deletion Syndrome 22q13.3 Deletion Syndrome Telomeric 22q13 Monosomy Syndrome PHMDS Deletion 22q13 Syndrome 22q13.3 Deletion Deletion 22q13.3 Syndrome Monosomy 22q13 Monosomy 22q13.3 22q13 Deletion Syndrome Monosomy 22q13 Syndrome 22q13 Deletion Chromosome Deletion
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100001	SKF-96365 (hydrochloride)		99.93%	Unkown
HY-125942	SKF-96365		99.97%	Unkown
HY-RS06283	HOMER1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21139	Homer1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27657	Homer1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HOMER1	VGNC	VGNC:73405
Mus musculus	HOMER1	MGD	MGI:1347345
Felis catus	HOMER1	VGNC	VGNC:62830
Canis familiaris	HOMER1	VGNC	VGNC:41737
Rattus norvegicus	HOMER1	RGD	RGD:628725
Bos taurus	HOMER1	VGNC	VGNC:29901
Others	HOMER1	NCBI