TRAF5 - TNF receptor associated factor 5 Gene

Also Known as RNF84; MGC:39780

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7188

About TRAF5

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,326,635-211,374,946 (from NCBI)

This gene has 7 transcripts (splice variants), 143 orthologues and 5 paralogues. Broad expression in lymph node (RPKM 13.9), appendix (RPKM 8.7) and 24 other tissues.

Summary

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF Receptor Superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

TRAF5 Products (4)

mRNA Protein Name
NM_001033910.3 NP_001029082.1 TNF receptor-associated factor 5 isoform b
NM_001319207.2 NP_001306136.1 TNF receptor-associated factor 5 isoform a
NM_004619.4 NP_004610.1 TNF receptor-associated factor 5 isoform b
NM_145759.3 NP_665702.1 TNF receptor-associated factor 5 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22493164 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9153189 GOA
enables thioesterase binding IPI
IPI: Inferred from physical interaction
11279055 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
26453305 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
11279055 GOA
Biological Process GO Annotation Evidence References Source
involved in CD40 signaling pathway IDA
IDA: Inferred from direct assay
15708970 GOA
involved in positive regulation of DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
12296995 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
12296995 GOA
involved in positive regulation of canonical NF-kappaB signal transduction IEP
IEP: Inferred from expression pattern
12761501 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
15121867 GOA
located in cytosol IDA
IDA: Inferred from direct assay
15121867 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAF5 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (45 - 82)

zf-TRAF

zf-TRAF: TRAF-type zinc finger (183 - 241)

MATH

MATH: MATH domain (417 - 550)

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  • 500
  • 557 a.a.
Protein Preferred Names Protein Names

TNF receptor-associated factor 5

  • RING finger protein 84

TRAF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRAF5 O00463 ENOX2 Homo sapiens Q16206-2
Y2H Prey Pooling
25416956
Intra
TRAF5 O00463 CCDC184 Homo sapiens Q52MB2
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 CCDC184 Homo sapiens Q52MB2
Validated Y2H
32296183
Intra
TRAF5 O00463 CCDC184 Homo sapiens Q52MB2
Y2H Array
32296183
Intra
TRAF5 O00463 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra
TRAF5 O00463 SEC13 Homo sapiens P55735
Y2H Prey Pooling
25416956
Intra
TRAF5 O00463 GAS8 Homo sapiens O95995
Validated Y2H
32296183
Intra
TRAF5 O00463 STIP1 Homo sapiens P31948
Validated Y2H
32814053
Intra
TRAF5 O00463 STIP1 Homo sapiens P31948
Y2H Pooling
32814053
Intra
TRAF5 O00463 STIP1 Homo sapiens P31948
Y2H Array
32814053
Intra
TRAF5 O00463 TNFRSF14 Homo sapiens Q92956
CoIP
9153189
Intra
TRAF5 O00463 TNFRSF14 Homo sapiens Q92956
Y2H
9153189
Intra
TRAF5 O00463 YPEL5 Homo sapiens P62699
Validated Y2H
32296183
Intra
TRAF5 O00463 SEC13 Homo sapiens P55735-3
Validated Y2H
32296183
Intra
TRAF5 O00463 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra
TRAF5 O00463 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
TRAF5 O00463 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
TRAF5 O00463 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra
TRAF5 O00463 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra
TRAF5 O00463 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra
TRAF5 O00463 RNF4 Homo sapiens P78317
Validated Y2H
32296183
Intra
TRAF5 O00463 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
TRAF5 O00463 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 LMO4 Homo sapiens P61968
Validated Y2H
32296183
Intra
TRAF5 O00463 CDC37 Homo sapiens Q16543
Validated Y2H
32296183
Intra
TRAF5 O00463 PIAS2 Homo sapiens O75928-2
Validated Y2H
32296183
Intra
TRAF5 O00463 PIAS2 Homo sapiens O75928-2
Y2H Array
32296183
Intra
TRAF5 O00463 PIAS2 Homo sapiens O75928-2
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
TRAF5 O00463 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
TRAF5 O00463 TRAF3 Homo sapiens Q13114
PLA
25241761
Intra
TRAF5 O00463 TRAF3 Homo sapiens Q13114
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 TRAF3 Homo sapiens Q13114
Validated Y2H
32296183
Intra
TRAF5 O00463 TRAF3 Homo sapiens Q13114
Y2H Array
32296183
Intra
TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Y2H
21516116
Intra
TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
27107012
Intra
TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra
TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Y2H Array
32296183
Intra
TRAF5 O00463 TRAF6 Homo sapiens Q9Y4K3
Y2H Prey Pooling
25416956
Intra
TRAF5 O00463 PSMA1 Homo sapiens P25786
Validated Y2H
32296183
Intra
TRAF5 O00463 NMI Homo sapiens Q13287
Y2H Array
25416956
Intra
TRAF5 O00463 NMI Homo sapiens Q13287
Validated Y2H
27107012
Intra
TRAF5 O00463 NMI Homo sapiens Q13287
Y2H Array
32296183
Intra
TRAF5 O00463 NMI Homo sapiens Q13287
Y2H
21516116
Intra
TRAF5 O00463 NMI Homo sapiens Q13287
Validated Y2H
32296183
Intra
TRAF5 O00463 NMI Homo sapiens Q13287
Validated Y2H
25416956
Intra
TRAF5 O00463 NMI Homo sapiens Q13287
Y2H Prey Pooling
25416956
Intra
TRAF5 O00463 NMI Homo sapiens Q13287
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 SRSF1 Homo sapiens Q07955
Anti Bait CoIP
21822258
Intra
TRAF5 O00463 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
TRAF5 O00463 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
TRAF5 O00463 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
TRAF5 O00463 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
TRAF5 O00463 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
TRAF5 O00463 HSF2BP Homo sapiens O75031
Validated Y2H
32296183
Intra
TRAF5 O00463 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
TRAF5 O00463 SERPINB9 Homo sapiens P50453
Y2H Array
25416956
Intra
TRAF5 O00463 SERPINB9 Homo sapiens P50453
Validated Y2H
32296183
Intra
TRAF5 O00463 SERPINB9 Homo sapiens P50453
Validated Y2H
25416956
Intra
TRAF5 O00463 PHYH Homo sapiens O14832
Y2H Pooling
32814053
Intra
TRAF5 O00463 PHYH Homo sapiens O14832
Validated Y2H
32814053
Intra
TRAF5 O00463 PHYH Homo sapiens O14832
Y2H Array
32814053
Intra
TRAF5 O00463 SDCBP Homo sapiens O00560
Y2H Prey Pooling
25416956
Intra
TRAF5 O00463 SDCBP Homo sapiens O00560
Validated Y2H
25416956
Intra
TRAF5 O00463 SDCBP Homo sapiens O00560
Validated Y2H
32296183
Intra
TRAF5 O00463 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra
TRAF5 O00463 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TRAF5 O00463 FBXO28 Homo sapiens Q9NVF7
Validated Y2H
32296183
Intra
TRAF5 O00463 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
TRAF5 O00463 THAP7 Homo sapiens Q9BT49
Validated Y2H
32296183
Intra
TRAF5 O00463 THAP1 Homo sapiens Q9NVV9
Validated Y2H
32296183
Intra
TRAF5 O00463 THAP1 Homo sapiens Q9NVV9
Y2H Array
32296183
Intra
TRAF5 O00463 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 RAD23A Homo sapiens P54725
Y2H Prey Pooling
25416956
Intra
TRAF5 O00463 HOMER1 Homo sapiens Q86YM7
Validated Y2H
32296183
Intra
TRAF5 O00463 HOMER1 Homo sapiens Q86YM7
Y2H Array
32296183
Intra
TRAF5 O00463 HOMER1 Homo sapiens Q86YM7
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
Intra
TRAF5 O00463 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
Intra
TRAF5 O00463 SUMO1 Homo sapiens P63165
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 SUMO1 Homo sapiens P63165
Validated Y2H
32296183
Intra
TRAF5 O00463 SUMO1 Homo sapiens P63165
Y2H Array
32296183
Intra
TRAF5 O00463 FAM9A Homo sapiens Q8IZU1
Validated Y2H
32296183
Intra
TRAF5 O00463 FAM9A Homo sapiens Q8IZU1
Y2H Array
32296183
Intra
TRAF5 O00463 FAM9A Homo sapiens Q8IZU1
Y2H Prey Pooling
32296183
Intra
TRAF5 O00463 ODF2 Homo sapiens Q5BJF6-2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myeloma, Multiple

  • Multiple Myeloma

  • Plasma Cell Myeloma

  • Kahler Disease

  • Myelomatosis

  • Medullary Plasmacytoma

  • Multiple Myeloma, Resistance To

  • Myeloma

  • Plasma Cell Dyscrasia

  • Kahler'S Disease

  • Multiple Myeloma, Susceptibility To

  • Myeloma - Multiple

  • Kahler-Bozzolo Disease

  • Plasma Cell Myelomas

  • MM

  • Plasma Cell Neoplasm

  • Primary Systemic Amyloidosis

  • Primary Amyloidosis

  • Immunoglobulin Deposition Disease

  • Plasmacytic Myeloma

  • Multiple Myelomata

  • Multiple Myeloma Nos

  • Multiple Myeloma Without Mention Of Remission

  • Monostotic Plasma Cell Myeloma

  • Mm - [Multiple Myeloma]
Plasma Cell Neoplasm

  • Plasma Cell Dyscrasia

  • Paraproteinemias

  • Plasma Cell Tumour

  • Plasmacytic Tumor

  • Multiple Myeloma

  • Plasmacytoma

  • Plasma Cell Tumours

  • Plasma Cells Dyscrasia
Ectodermal Dysplasia

  • Congenital Ectodermal Defect

  • Congenital Ectodermal Dysplasia

  • Ectodermal Dysplasia Syndrome

  • Dysplasia, Ectodermal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14974 TRAF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174514 Human TNFRSF4 mRNA / Unkown
HY-RS22873 Traf5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29387 Traf5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TRAF5 VGNC VGNC:47769
Bos taurus TRAF5 VGNC VGNC:36277
Rattus norvegicus TRAF5 RGD RGD:1593883
Felis catus TRAF5 VGNC VGNC:66501
Macaca mulatta TRAF5 VGNC VGNC:78644
Mus musculus TRAF5 MGD MGI:107548
Others TRAF5 NCBI