TRAF5 - TNF receptor associated factor 5 Gene

Homo sapiens

Also known as RNF84; MGC:39780

Gene ID: 7188 | Gene type: protein coding

About TRAF5

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:211,326,635-211,374,946 (from NCBI)

This gene has 7 transcripts (splice variants), 143 orthologues and 5 paralogues. Broad expression in lymph node (RPKM 13.9), appendix (RPKM 8.7) and 24 other tissues.

Summary

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF Receptor Superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

TRAF5 Products(4)

mRNA	Protein	Name
NM_001033910.3	NP_001029082.1	TNF receptor-associated factor 5 isoform b
NM_001319207.2	NP_001306136.1	TNF receptor-associated factor 5 isoform a
NM_004619.4	NP_004610.1	TNF receptor-associated factor 5 isoform b
NM_145759.3	NP_665702.1	TNF receptor-associated factor 5 isoform b

TRAF5 Protein Structure

zf-C3HC4

zf-TRAF

MATH

0
100
200
300
400
500
557 a.a.

Protein Preferred Names

Protein Names

TNF receptor-associated factor 5

RING finger protein 84

Related Diseases

Diseases

Alias

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Ectodermal Dysplasia

Congenital Ectodermal Defect	Congenital Ectodermal Dysplasia
Ectodermal Dysplasia Syndrome	Dysplasia, Ectodermal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14974	TRAF5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TRAF5	VGNC	VGNC:47769
Bos taurus	TRAF5	VGNC	VGNC:36277
Rattus norvegicus	TRAF5	RGD	RGD:1593883
Felis catus	TRAF5	VGNC	VGNC:66501
Macaca mulatta	TRAF5	VGNC	VGNC:78644
Mus musculus	TRAF5	MGD	MGI:107548

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