RAD23A - RAD23 homolog A, nucleotide excision repair protein Gene

Also Known as HR23A; HHR23A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5886

About RAD23A

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,945,862-12,953,642 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 50.3), heart (RPKM 47.4) and 25 other tissues.

Summary

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the Proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

RAD23A Products (3)

mRNA	Protein	Name
NM_001270362.2	NP_001257291.1	UV excision repair protein RAD23 homolog A isoform 2
NM_001270363.2	NP_001257292.1	UV excision repair protein RAD23 homolog A isoform 3
NM_005053.4	NP_005044.1	UV excision repair protein RAD23 homolog A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	26296656	GOA
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	12643283	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10488153	GOA
enables ubiquitin-specific protease binding	IPI IPI: Inferred from physical interaction	22970133	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nucleotide-excision repair	IDA IDA: Inferred from direct assay	9372924	GOA
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	26296656	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	26296656	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	20614012	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	26296656	GOA
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	12643283	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	26296656	GOA
located in nucleus	IDA IDA: Inferred from direct assay	26296656	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	26296656	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAD23A Protein Structure

ubiquitin

UBA

XPC-binding

UBA

0
100
200
300
363 a.a.

Protein Preferred Names	Protein Names
UV excision repair protein RAD23 homolog A	RAD23, yeast homolog, A

RAD23A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAD23A	P54725	KRTAP12-2	Homo sapiens	P59991	Y2H Array	32296183
Intra	RAD23A	P54725	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	KRTAP12-2	Homo sapiens	P59991	Validated Y2H	32296183
Intra	RAD23A	P54725	FAM22F	Homo sapiens	B7ZLH0	Y2H Array	32296183
Intra	RAD23A	P54725	FAM22F	Homo sapiens	B7ZLH0	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	RAD23A	P54725	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	RAD23A	P54725	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	TRIM55	Homo sapiens	Q9BYV6-2	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	TRIM55	Homo sapiens	Q9BYV6-2	Validated Y2H	32296183
Intra	RAD23A	P54725	TRIM55	Homo sapiens	Q9BYV6-2	Y2H Array	32296183
Intra	RAD23A	P54725	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	RAD23A	P54725	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	RAD23A	P54725	UBXN1	Homo sapiens	Q04323-2	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	UBXN1	Homo sapiens	Q04323-2	Validated Y2H	32296183
Intra	RAD23A	P54725	UBXN1	Homo sapiens	Q04323-2	Y2H Array	32296183
Intra	RAD23A	P54725	ATXN3	Homo sapiens	Q4VBR4	Y2H Array	32814053
Intra	RAD23A	P54725	ATXN3	Homo sapiens	Q4VBR4	Validated Y2H	32814053
Intra	RAD23A	P54725	ATXN3	Homo sapiens	Q4VBR4	Y2H Array	32296183
Intra	RAD23A	P54725	ATXN3	Homo sapiens	Q4VBR4	Y2H Pooling	32814053
Intra	RAD23A	P54725	ATXN3	Homo sapiens	Q4VBR4	Validated Y2H	32296183
Intra	RAD23A	P54725	ATXN3	Homo sapiens	Q4VBR4	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	RABGEF1	Homo sapiens	Q9UJ41-4	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	RABGEF1	Homo sapiens	Q9UJ41-4	Y2H Array	32296183
Intra	RAD23A	P54725	RABGEF1	Homo sapiens	Q9UJ41-4	Validated Y2H	32296183
Intra	RAD23A	P54725	UIMC1	Homo sapiens	Q96RL1-2	Validated Y2H	32296183
Intra	RAD23A	P54725	UIMC1	Homo sapiens	Q96RL1-2	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	UIMC1	Homo sapiens	Q96RL1-2	Y2H Array	32296183
Intra	RAD23A	P54725	RNF41	Homo sapiens	Q9H4P4	Validated Y2H	32296183
Intra	RAD23A	P54725	RNF41	Homo sapiens	Q9H4P4	Y2H Array	32296183
Intra	RAD23A	P54725	RNF41	Homo sapiens	Q9H4P4	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	RAD23A	P54725	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	RAD23A	P54725	TRIM8	Homo sapiens	Q9BZR9	Validated Y2H	32296183
Intra	RAD23A	P54725	TRIM8	Homo sapiens	Q9BZR9	Y2H Array	32296183
Intra	RAD23A	P54725	TRIM8	Homo sapiens	Q9BZR9	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	USP25	Homo sapiens	Q9UHP3	Validated Y2H	32296183
Intra	RAD23A	P54725	USP25	Homo sapiens	Q9UHP3	Y2H Array	25416956
Intra	RAD23A	P54725	USP25	Homo sapiens	Q9UHP3	Y2H Array	32296183
Intra	RAD23A	P54725	USP25	Homo sapiens	Q9UHP3	Y2H Prey Pooling	25416956
Intra	RAD23A	P54725	USP25	Homo sapiens	Q9UHP3	Validated Y2H	25416956
Intra	RAD23A	P54725	USP25	Homo sapiens	Q9UHP3	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	ITGAV	Homo sapiens	P06756	Validated Y2H	32814053
Intra	RAD23A	P54725	ITGAV	Homo sapiens	P06756	Y2H Array	32814053
Intra	RAD23A	P54725	ITGAV	Homo sapiens	P06756	Y2H Pooling	32814053
Intra	RAD23A	P54725	SQSTM1	Homo sapiens	Q13501	Pull Down	16189514
Intra	RAD23A	P54725	SQSTM1	Homo sapiens	Q13501	Y2H Pooling	16189514
Intra	RAD23A	P54725	EEF1A1	Homo sapiens	P68104	Pull Down	16712842
Intra	RAD23A	P54725	TRAF2	Homo sapiens	Q12933	Validated Y2H	25416956
Intra	RAD23A	P54725	TRAF2	Homo sapiens	Q12933	Y2H Pooling	16189514
Intra	RAD23A	P54725	TRAF2	Homo sapiens	Q12933	Validated Y2H	32296183
Intra	RAD23A	P54725	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	RAD23A	P54725	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	25416956
Intra	RAD23A	P54725	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	UBA52	Homo sapiens	P62987	Validated Y2H	32296183
Intra	RAD23A	P54725	UBA52	Homo sapiens	P62987	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	UBA52	Homo sapiens	P62987	Y2H Array	32296183
Intra	RAD23A	P54725	RPS27A	Homo sapiens	P62979	Validated Y2H	32296183
Intra	RAD23A	P54725	RPS27A	Homo sapiens	P62979	Y2H Array	32296183
Intra	RAD23A	P54725	RPS27A	Homo sapiens	P62979	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	TRAF3	Homo sapiens	Q13114	Validated Y2H	32296183
Intra	RAD23A	P54725	TRAF3	Homo sapiens	Q13114	Y2H Array	32296183
Intra	RAD23A	P54725	TRAF3	Homo sapiens	Q13114	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	TRAF6	Homo sapiens	Q9Y4K3	Validated Y2H	32296183
Intra	RAD23A	P54725	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	32296183
Intra	RAD23A	P54725	PSMD4	Homo sapiens	P55036	Pull Down	10488153
Intra	RAD23A	P54725	PSMD4	Homo sapiens	P55036	SPR	12970176
Intra	RAD23A	P54725	PSMD4	Homo sapiens	P55036	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	PSMD4	Homo sapiens	P55036	Validated Y2H	32296183
Intra	RAD23A	P54725	PSMD4	Homo sapiens	P55036	Y2H Array	32296183
Intra	RAD23A	P54725	PSMD4	Homo sapiens	P55036	Y2H	10488153
Intra	RAD23A	P54725	PSMD4	Homo sapiens	P55036	Pull Down	20059542
Intra	RAD23A	P54725	MKRN1	Homo sapiens	Q9UHC7	Validated Y2H	32296183
Intra	RAD23A	P54725	MKRN1	Homo sapiens	Q9UHC7	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	MKRN1	Homo sapiens	Q9UHC7	Y2H Array	32296183
Intra	RAD23A	P54725	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
Intra	RAD23A	P54725	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	RAD23A	P54725	TRAF5	Homo sapiens	O00463	Y2H Array	25416956
Intra	RAD23A	P54725	TRAF5	Homo sapiens	O00463	Validated Y2H	25416956
Intra	RAD23A	P54725	TNFAIP3	Homo sapiens	P21580	Y2H Array	32296183
Intra	RAD23A	P54725	TNFAIP3	Homo sapiens	P21580	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	ZBTB44	Homo sapiens	Q8NCP5	Y2H Prey Pooling	25416956
Intra	RAD23A	P54725	ZBTB44	Homo sapiens	Q8NCP5	Validated Y2H	25416956
Intra	RAD23A	P54725	SGCA	Homo sapiens	Q16586	Y2H Pooling	32814053
Intra	RAD23A	P54725	SGCA	Homo sapiens	Q16586	Validated Y2H	32814053
Intra	RAD23A	P54725	SGCA	Homo sapiens	Q16586	Y2H Array	32814053
Intra	RAD23A	P54725	NGLY1	Homo sapiens	Q96IV0	Y2H Array	31515488
Intra	RAD23A	P54725	NGLY1	Homo sapiens	Q96IV0	Validated Y2H	25416956
Intra	RAD23A	P54725	NGLY1	Homo sapiens	Q96IV0	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	NGLY1	Homo sapiens	Q96IV0	Validated Y2H	32296183
Intra	RAD23A	P54725	NGLY1	Homo sapiens	Q96IV0	Y2H Array	25416956
Intra	RAD23A	P54725	NGLY1	Homo sapiens	Q96IV0	Y2H Array	32296183
Intra	RAD23A	P54725	DAZAP2	Homo sapiens	Q15038	Validated Y2H	32296183
Intra	RAD23A	P54725	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	RAD23A	P54725	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	ZFAND6	Homo sapiens	Q6FIF0	Validated Y2H	32296183
Intra	RAD23A	P54725	ZFAND6	Homo sapiens	Q6FIF0	Y2H Array	32296183
Intra	RAD23A	P54725	ZFAND6	Homo sapiens	Q6FIF0	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	MINDY3	Homo sapiens	Q9H8M7	Y2H Array	31515488
Intra	RAD23A	P54725	MINDY3	Homo sapiens	Q9H8M7	Validated Y2H	25416956
Intra	RAD23A	P54725	MINDY3	Homo sapiens	Q9H8M7	Y2H Prey Pooling	25416956
Intra	RAD23A	P54725	MINDY3	Homo sapiens	Q9H8M7	Validated Y2H	32296183
Intra	RAD23A	P54725	MINDY3	Homo sapiens	Q9H8M7	Y2H Array	25416956
Intra	RAD23A	P54725	MINDY3	Homo sapiens	Q9H8M7	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	MINDY3	Homo sapiens	Q9H8M7	Y2H Array	32296183
Intra	RAD23A	P54725	TRIP6	Homo sapiens	Q15654	Validated Y2H	25416956
Intra	RAD23A	P54725	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	25416956
Intra	RAD23A	P54725	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	RAD23A	P54725	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	25416956
Intra	RAD23A	P54725	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	RAD23A	P54725	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	25416956
Intra	RAD23A	P54725	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	CSNK1D	Homo sapiens	P48730-2	Y2H Pooling	32814053
Intra	RAD23A	P54725	CSNK1D	Homo sapiens	P48730-2	Validated Y2H	32814053
Intra	RAD23A	P54725	CSNK1D	Homo sapiens	P48730-2	Y2H Array	32814053
Intra	RAD23A	P54725	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	RAD23A	P54725	UBQLN2	Homo sapiens	Q9UHD9	NMR	17098253
Intra	RAD23A	P54725	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	RAD23A	P54725	CNTROB	Homo sapiens	Q8N137	Validated Y2H	32296183
Intra	RAD23A	P54725	CNTROB	Homo sapiens	Q8N137	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	CNTROB	Homo sapiens	Q8N137	Y2H Array	32296183
Intra	RAD23A	P54725	TRIM50	Homo sapiens	Q86XT4	Y2H Prey Pooling	32296183
Intra	RAD23A	P54725	TRIM50	Homo sapiens	Q86XT4	Validated Y2H	32296183
Intra	RAD23A	P54725	TRIM50	Homo sapiens	Q86XT4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RAD23A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82846	hHR23A Antibody (YA2591)	WB, FC	Human, Mouse, Rat
HY-P84396	hHR23A Antibody (YA4093)	IHC-P, FC, ELISA	Human
HY-P84396A	hHR23A Antibody (YA4093)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Xeroderma Pigmentosum, Complementation Group C	Xeroderma Pigmentosum, Group C XPC Xpcc Xeroderma Pigmentosum Iii Xp3 Xeroderma Pigmentosum Group C Xp Group C Xp, Group C Xeroderma Pigmentosum, Type 3 Xeroderma Pigmentosum Complementation Group C XP-C
Angelman Syndrome	AS Happy Puppet Syndrome Happy Puppet Syndrome, Formerly Puppetlike Syndrome
Brain Sarcoma	Sarcoma Of The Brain
Hyperinsulinemic Hypoglycemia, Familial, 2	Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi Familial Hyperinsulinism Congenital Hyperinsulinism HHF2 Nesidioblastosis Hyperinsulinemic Hypoglycemia Due To Focal Adenomatous Hyperplasia Familial Hyperinsulinemic Hypoglycemia 2 Autosomal Recessive Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency Chi Congenital Isolated Hyperinsulinism Hyperinsulinemic Hypoglycemia, Persistent Hyperinsulinism, Neonatal Hyperinsulinism, Congenital Hyperinsulinism, Familial Hyperinsulinemic Hypoglycemia Familial Hyperinsulinism Congenital Hyperinsulinism Familial With Pancreatic Nesidioblastosis Hypoglycemia Hyperinsulinemic Of Infancy Nesidioblastosis Of Pancreas Hyperinsulinemic Hypoglycemia Familial 2 Hyperinsulinemia Hypoglycemia Of Infancy Infancy Hyperinsulinemia Hypoglycemia Neonatal Hyperinsulinism Persistent Hyperinsulinemia Hypoglycemia Of Infancy Persistent Hyperinsulinemic Hypoglycemia Phhi Hypoglycemia Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency Autosomal Dominant Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency Dominant Katp Hyperinsulinism Due To Kir6.2 Deficiency Diazoxide-Resistant Focal Hyperinsulinism Due To Kir6.2 Deficiency Hyperinsulinemic Hypoglycemia Due To Kir6.2 Deficiency, Diazoxide-Resistant Focal Form Fhi Familial Hyperinsulinemic Hypoglycemia Autosomal Recessive Hyperinsulinism Due To Kir6.2 Deficiency Hypoglycemia, Hyperinsulinemic, Familial, Type 2 Hi-C

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11600	RAD23A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RAD23A	VGNC	VGNC:76643
Felis catus	RAD23A	VGNC	VGNC:69213
Mus musculus	RAD23A	MGD	MGI:105126
Rattus norvegicus	RAD23A	RGD	RGD:1309899
Canis familiaris	RAD23A	VGNC	VGNC:45315
Bos taurus	RAD23A	VGNC	VGNC:33682
Others	RAD23A	NCBI