SQSTM1 - sequestosome 1 Gene
Also Known as p60; p62; A170; DMRV; OSIL; PDB3; ZIP3; p62B; NADGP; FTDALS3
Species: Homo sapiens
About SQSTM1
This gene has 16 transcripts (splice variants), 1 gene allele, 212 orthologues and is associated with 9 phenotypes. Ubiquitous expression in thyroid (RPKM 57.3), gall bladder (RPKM 54.3) and 25 other tissues.
Summary
This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]
SQSTM1 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001142298.2 | NP_001135770.1 | sequestosome-1 isoform 2 |
| NM_001142299.2 | NP_001135771.1 | sequestosome-1 isoform 2 |
| NM_003900.5 | NP_003891.1 | sequestosome-1 isoform 1 |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in P-body |
IDA
IDA: Inferred from direct assay
|
20357094 | GOA |
| located in PML body |
IDA
IDA: Inferred from direct assay
|
20168092 | GOA |
| located in amphisome |
IDA
IDA: Inferred from direct assay
|
19640926 | GOA |
| located in autolysosome |
IDA
IDA: Inferred from direct assay
|
19640926 | GOA |
| is active in autophagosome |
IDA
IDA: Inferred from direct assay
|
30612879 | GOA |
| located in autophagosome |
IDA
IDA: Inferred from direct assay
|
17580304 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
20168092 | GOA |
| is active in cytosol |
IDA
IDA: Inferred from direct assay
|
8650207 | GOA |
| located in inclusion body |
IDA
IDA: Inferred from direct assay
|
20168092 | GOA |
| is active in intracellular non-membrane-bounded organelle |
IDA
IDA: Inferred from direct assay
|
22017874 | GOA |
SQSTM1 Protein Structure
PB1: PB1 domain (41 - 100)
ZZ: Zinc finger, ZZ type (123 - 158)
- 0
- 100
- 200
- 300
- 400
- 440 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
sequestosome-1 |
|
SQSTM1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SQSTM1 | Q13501 | NTRK1 | Homo sapiens | P04629 | 17389358 | |
|
Intra
|
SQSTM1 | Q13501 | MALT1 | Homo sapiens | Q9UDY8 | 16874300 | |
|
Intra
|
SQSTM1 | Q13501 | MALT1 | Homo sapiens | Q9UDY8 | 16874300 | |
|
Intra
|
SQSTM1 | Q13501 | HSPA1A | Homo sapiens | P0DMV8 | 32814053 | |
|
Intra
|
SQSTM1 | Q13501 | HSPA1A | Homo sapiens | P0DMV8 | 32814053 | |
|
Intra
|
SQSTM1 | Q13501 | HSPA1A | Homo sapiens | P0DMV8 | 32814053 | |
|
Intra
|
SQSTM1 | Q13501 | MAP1LC3C | Homo sapiens | Q9BXW4 | 19250911 | |
|
Intra
|
SQSTM1 | Q13501 | MAP1LC3C | Homo sapiens | Q9BXW4 | 33436498 | |
|
Intra
|
SQSTM1 | Q13501 | MAP1LC3C | Homo sapiens | Q9BXW4 | 20562859 | |
|
Cross
|
SQSTM1 | Q13501 | ATG8 | Saccharomyces cerevisiae | P38182 | 19250911 | |
|
Cross
|
SQSTM1 | Q13501 | ATG8 | Saccharomyces cerevisiae | P38182 | 19250911 | |
|
Intra
|
SQSTM1 | Q13501 | CNR2 | Homo sapiens | P34972 | 31616248 | |
|
Intra
|
SQSTM1 | Q13501 | CNR2 | Homo sapiens | P34972 | 31616248 | |
|
Intra
|
SQSTM1 | Q13501 | PRKCI | Homo sapiens | P41743 | 20808283 | |
|
Intra
|
SQSTM1 | Q13501 | PRKCI | Homo sapiens | P41743 | 20562859 | |
|
Intra
|
SQSTM1 | Q13501 | PRKCI | Homo sapiens | P41743 | 34524948 | |
|
Intra
|
SQSTM1 | Q13501 | VDR | Homo sapiens | P11473 | 27728806 | |
|
Intra
|
SQSTM1 | Q13501 | CDC37 | Homo sapiens | Q16543 | 32296183 | |
|
Intra
|
SQSTM1 | Q13501 | CDC37 | Homo sapiens | Q16543 | 20562859 | |
|
Intra
|
SQSTM1 | Q13501 | MAP1LC3B | Homo sapiens | Q9GZQ8 | 19250911 | |
|
Intra
|
SQSTM1 | Q13501 | NIPSNAP1 | Homo sapiens | Q9BPW8 | 34524948 | |
|
Intra
|
SQSTM1 | Q13501 | NIPSNAP1 | Homo sapiens | Q9BPW8 | 35271311 | |
|
Intra
|
SQSTM1 | Q13501 | NIPSNAP1 | Homo sapiens | Q9BPW8 | 20562859 | |
|
Intra
|
SQSTM1 | Q13501 | MAP2K5 | Homo sapiens | Q13163 | 32296183 | |
|
Intra
|
SQSTM1 | Q13501 | UBC | Homo sapiens | P0CG48 | 8702753 | |
|
Intra
|
SQSTM1 | Q13501 | UBC | Homo sapiens | P0CG48 | 21900206 | |
|
Intra
|
SQSTM1 | Q13501 | SH3KBP1 | Homo sapiens | Q96B97 | 20551902 | |
|
Intra
|
SQSTM1 | Q13501 | SH3KBP1 | Homo sapiens | Q96B97 | 20551902 | |
|
Intra
|
SQSTM1 | Q13501 | SMAD3 | Homo sapiens | P84022 | 21988832 | |
|
Intra
|
SQSTM1 | Q13501 | PTPN13 | Homo sapiens | Q12923 | 24316673 | |
|
Intra
|
SQSTM1 | Q13501 | TRAF6 | Homo sapiens | Q9Y4K3 | 17389358 | |
|
Intra
|
SQSTM1 | Q13501 | SESN2 | Homo sapiens | P58004 | 25040165 | |
|
Intra
|
SQSTM1 | Q13501 | LRRK2 | Homo sapiens | Q5S007 | 29519959 | |
|
Intra
|
SQSTM1 | Q13501 | FHOD3 | Homo sapiens | Q2V2M9-4 | 21149568 | |
|
Intra
|
SQSTM1 | Q13501 | FHOD3 | Homo sapiens | Q2V2M9-4 | 21149568 | |
|
Intra
|
SQSTM1 | Q13501 | FHOD3 | Homo sapiens | Q2V2M9 | 21149568 | |
|
Intra
|
SQSTM1 | Q13501 | FHOD3 | Homo sapiens | Q2V2M9 | 21149568 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAP | Homo sapiens | O95166 | 32296183 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAP | Homo sapiens | O95166 | 20562859 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAP | Homo sapiens | O95166 | 32296183 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAP | Homo sapiens | O95166 | 33436498 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAP | Homo sapiens | O95166 | 19250911 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL2 | Homo sapiens | P60520 | 19250911 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL2 | Homo sapiens | P60520 | 25416956 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL2 | Homo sapiens | P60520 | 33436498 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL2 | Homo sapiens | P60520 | 20562859 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL2 | Homo sapiens | P60520 | 25416956 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL2 | Homo sapiens | P60520 | 16189514 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL2 | Homo sapiens | P60520 | 19250911 | |
|
Intra
|
SQSTM1 | Q13501 | MAP1LC3A | Homo sapiens | Q9H492 | 32296183 | |
|
Intra
|
SQSTM1 | Q13501 | MAP1LC3A | Homo sapiens | Q9H492 | 19250911 | |
|
Intra
|
SQSTM1 | Q13501 | MAP1LC3A | Homo sapiens | Q9H492 | 33436498 | |
|
Intra
|
SQSTM1 | Q13501 | MAP1LC3A | Homo sapiens | Q9H492 | 19427866 | |
|
Intra
|
SQSTM1 | Q13501 | DAZAP2 | Homo sapiens | Q15038 | 32296183 | |
|
Intra
|
SQSTM1 | Q13501 | NBR1 | Homo sapiens | Q14596 | 19250911 | |
|
Intra
|
SQSTM1 | Q13501 | NBR1 | Homo sapiens | Q14596 | 20808283 | |
|
Intra
|
SQSTM1 | Q13501 | NBR1 | Homo sapiens | Q14596 | 24879152 | |
|
Intra
|
SQSTM1 | Q13501 | NBR1 | Homo sapiens | Q14596 | 19250911 | |
|
Intra
|
SQSTM1 | Q13501 | NBR1 | Homo sapiens | Q14596 | 20562859 | |
|
Intra
|
SQSTM1 | Q13501 | RAD23A | Homo sapiens | P54725 | 31515488 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL1 | Homo sapiens | Q9H0R8 | 25416956 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL1 | Homo sapiens | Q9H0R8 | 20562859 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL1 | Homo sapiens | Q9H0R8 | 32296183 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL1 | Homo sapiens | Q9H0R8 | 25416956 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL1 | Homo sapiens | Q9H0R8 | 16189514 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL1 | Homo sapiens | Q9H0R8 | 19250911 | |
|
Intra
|
SQSTM1 | Q13501 | GABARAPL1 | Homo sapiens | Q9H0R8 | 25416956 | |
|
Intra
|
SQSTM1 | Q13501 | OPTN | Homo sapiens | Q96CV9 | 25026213 | |
|
Intra
|
SQSTM1 | Q13501 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
SQSTM1 | Q13501 | KEAP1 | Homo sapiens | Q14145 | 25416956 | |
|
Intra
|
SQSTM1 | Q13501 | KEAP1 | Homo sapiens | Q14145 | 25416956 | |
|
Intra
|
SQSTM1 | Q13501 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
SQSTM1 | Q13501 | KEAP1 | Homo sapiens | Q14145 | 25910212 | |
|
Intra
|
SQSTM1 | Q13501 | KEAP1 | Homo sapiens | Q14145 | 20562859 | |
|
Intra
|
SQSTM1 | Q13501 | KEAP1 | Homo sapiens | Q14145 | 25910212 | |
|
Intra
|
SQSTM1 | Q13501 | KEAP1 | Homo sapiens | Q14145 | 32296183 | |
|
Intra
|
SQSTM1 | Q13501 | KEAP1 | Homo sapiens | Q14145 | 25910212 | |
|
Intra
|
SQSTM1 | Q13501 | CLDN2 | Homo sapiens | P57739 | 37460613 | |
|
Intra
|
SQSTM1 | Q13501 | CLDN2 | Homo sapiens | P57739 | 37460613 | |
|
Intra
|
SQSTM1 | Q13501 | IKBKG | Homo sapiens | Q9Y6K9 | 16874300 | |
|
Intra
|
SQSTM1 | Q13501 | IKBKG | Homo sapiens | Q9Y6K9 | 16874300 | |
|
Cross
|
SQSTM1 | Q13501 | Ulk1 | Mus musculus | O70405 | 25040165 |
SQSTM1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80518 | SQSTM1/p62 Antibody (YA669) | IHC-P, FC | Human, Mouse, Rat |
| HY-P80899 | SQSTM1/p62 Antibody (YA062) | WB, IHC-F, IHC-P, ICC/IF, IP | Human |
| HY-P80899A | SQSTM1/p62 Antibody (YA062)(PBS only) | WB, IHC-F, IHC-P, ICC/IF, IP | Human |
| HY-P84545 | SQSTM1/p62 Antibody (YA4242) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Mouse, Rat, Rabbit, Monkey |
| HY-P84545A | SQSTM1/p62 Antibody (YA4242)(PBS only) | WB, IHC-P, ICC/IF, FC, ELISA | Human, Mouse, Rat, Rabbit, Monkey |
| HY-P86651 | SQSTM1/p62 Antibody (YA6343) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Paget Disease Of Bone 3 |
|
|
| Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3 |
|
|
| Neurodegeneration With Ataxia, Dystonia, And Gaze Palsy, Childhood-Onset |
|
|
| Myopathy, Distal, With Rimmed Vacuoles |
|
|
| Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1 |
|
|
| Paget'S Disease Of Bone |
|
|
| Spastic Paraplegia-Paget Disease Of Bone Syndrome |
|
|
| Paget Disease Of Bone 2, Early-Onset |
|
|
| Pick Disease Of Brain |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Welander Distal Myopathy |
|
|
| Familial Expansile Osteolysis |
|
|
| Frontotemporal Dementia |
|
|
| Dementia |
|
|
| Amyotrophic Lateral Sclerosis 3 |
|
|
| Motor Neuron Disease |
|
|
| Huntington Disease |
|
|
| Cystinosis |
|
|
| Lateral Sclerosis |
|
|
| Multiple System Atrophy 1 |
|
|
| Periostitis |
|
|
| Machado-Joseph Disease |
|
|
| Dystonia |
|
|
| Multisystem Proteinopathy |
|
|
| Pilocytic Astrocytoma |
|
|
| Hepatocellular Carcinoma |
|
|
| Mammary Paget'S Disease |
|
|
| Myopathy |
|
|
| Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia |
|
|
| Alcoholic Hepatitis |
|
|
| Muscular Atrophy |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Spinocerebellar Ataxia, Autosomal Recessive 20 |
|
|
| Ovarian Cancer |
|
|
| Myopathy, X-Linked, With Excessive Autophagy |
|
|
| Nonaka Myopathy |
|
|
| Breast Adenocarcinoma |
|
|
| Danon Disease |
|
|
| Charcot-Marie-Tooth Disease, Axonal, Type 2e |
|
|
| Diamond-Blackfan Anemia 20 |
|
|
| Macular Degeneration, Age-Related, 14 |
|
|
| Beach Ear |
|
|
| Liver Carcinoma In Situ |
|
|
| Pheochromocytoma |
|
|
| Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 2 |
|
|
| Neuronal Ceroid Lipofuscinosis |
|
|
| Myofibrillar Myopathy |
|
|
| Prostate Cancer |
|
|
| Dementia, Lewy Body |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Hereditary Spastic Paraplegia |
|
|
| Nervous System Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Charcot-Marie-Tooth Disease |
|
|
| Dilated Cardiomyopathy |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | SQSTM1 | VGNC | VGNC:65669 |
| Rattus norvegicus | SQSTM1 | RGD | RGD:69287 |
| Mus musculus | SQSTM1 | MGD | MGI:107931 |
| Canis familiaris | SQSTM1 | VGNC | VGNC:46787 |
| Macaca mulatta | SQSTM1 | VGNC | VGNC:77876 |
| Bos taurus | SQSTM1 | VGNC | VGNC:35265 |
| Others | SQSTM1 | NCBI |