SESN2 - sestrin 2 Gene

Also Known as HI95; SES2; SEST2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83667

About SESN2

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,259,518-28,282,491 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 189 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 15.0), kidney (RPKM 10.3) and 24 other tissues.

Summary

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]

SESN2 Products (1)

mRNA Protein Name
NM_031459.5 NP_113647.1 sestrin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-leucine binding IDA
IDA: Inferred from direct assay
26449471 GOA
enables peroxidase activity IDA
IDA: Inferred from direct assay
26612684 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15105503 GOA
enables protein sequestering activity IDA
IDA: Inferred from direct assay
26586190 GOA
NOT enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
26449471 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
25263562 GOA
NOT enables sulfiredoxin activity IDA
IDA: Inferred from direct assay
19113821 GOA
enables sulfiredoxin activity IDA
IDA: Inferred from direct assay
15105503 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
18692468 GOA
NOT involved in cellular oxidant detoxification IDA
IDA: Inferred from direct assay
19113821 GOA
involved in cellular oxidant detoxification IDA
IDA: Inferred from direct assay
26612684 GOA
involved in cellular oxidant detoxification IMP
IMP: Inferred from mutant phenotype
15105503 GOA
involved in cellular response to L-leucine IDA
IDA: Inferred from direct assay
26449471 GOA
involved in cellular response to L-leucine IMP
IMP: Inferred from mutant phenotype
26586190 GOA
involved in cellular response to amino acid starvation IMP
IMP: Inferred from mutant phenotype
25263562 GOA
involved in cellular response to amino acid stimulus IMP
IMP: Inferred from mutant phenotype
25457612 GOA
involved in cellular response to glucose starvation IMP
IMP: Inferred from mutant phenotype
25263562 GOA
involved in cellular response to leucine starvation IDA
IDA: Inferred from direct assay
35114100 GOA
involved in cellular response to leucine starvation IMP
IMP: Inferred from mutant phenotype
26449471 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
35114100 GOA
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
18692468 GOA
involved in negative regulation of translation in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
24947615 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
26449471 GOA
involved in positive regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
23274085 GOA
involved in positive regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
23274085 GOA
involved in reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
26612684 GOA
involved in reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
15105503 GOA
involved in regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
36528027 GOA
involved in regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
25040165 GOA
Cellular Component GO Annotation Evidence References Source
part of Atg1/ULK1 kinase complex IPI
IPI: Inferred from physical interaction
25040165 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
15105503 GOA
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
15105503 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SESN2 Protein Structure

PA26

PA26: PA26 p53-induced protein (sestrin) (42 - 480)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 480 a.a.
Protein Preferred Names Protein Names

sestrin-2

  • hypoxia induced gene 95

SESN2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
SESN2 P58004 Rbx1 Mus musculus P62878
Anti Tag CoIP
23274085
Intra
SESN2 P58004 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
25263562
Intra
SESN2 P58004 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
26586190
Intra
SESN2 P58004 MIOS Homo sapiens Q9NXC5
Anti Bait CoIP
28199315
Intra
SESN2 P58004 SQSTM1 Homo sapiens Q13501
Anti Tag CoIP
23274085
Intra
SESN2 P58004 SQSTM1 Homo sapiens Q13501
Pull Down
25040165
Intra
SESN2 P58004 SQSTM1 Homo sapiens Q13501
Anti Bait CoIP
25040165
Intra
SESN2 P58004 RBX1 Homo sapiens P62877
Anti Tag CoIP
23274085
Intra
SESN2 P58004 RBX1 Homo sapiens P62877
Anti Tag CoIP
29294217
Intra
SESN2 P58004 WDR24 Homo sapiens Q96S15
Anti Tag CoIP
26586190
Intra
SESN2 P58004 WDR24 Homo sapiens Q96S15
Anti Bait CoIP
28199315
Intra
SESN2 P58004 WDR24 Homo sapiens Q96S15
Anti Tag CoIP
25263562
Intra
SESN2 P58004 KEAP1 Homo sapiens Q14145
Anti Tag CoIP
23274085
Cross
SESN2 P58004 Ulk1 Mus musculus O70405
Anti Tag CoIP
25040165
Cross: Cross-species interaction Intra: Intraspecies interaction

SESN2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82189 SESN2 Antibody (YA1934) WB, ICC/IF, IP Human, Mouse, Rat
HY-P82189A SESN2 Antibody (YA1934)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat
HY-P86301 SESN2 Antibody (YA5993) WB, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Pulmonary Emphysema
Nodular Ganglioneuroblastoma

  • Ganglioneuroblastoma, Nodular
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2593 Isorhapontigenin 99.82% Unkown
HY-RS12735 SESN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20488 Sesn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26996 Sesn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SESN2 VGNC VGNC:77286
Bos taurus SESN2 VGNC VGNC:34489
Rattus norvegicus SESN2 RGD RGD:1566319
Canis familiaris SESN2 VGNC VGNC:46048
Felis catus SESN2 VGNC VGNC:65035
Mus musculus SESN2 MGD MGI:2651874
Others SESN2 NCBI